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Erschienen in: Pediatric Drugs 5/2001

01.05.2001 | Therapy In Practice

Pharmacological Management of Pain and Anxiety During Emergency Procedures in Children

verfasst von: Dr Robert M. Kennedy, Jan D. Luhmann

Erschienen in: Pediatric Drugs | Ausgabe 5/2001

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Abstract

Painful procedures are frequently required during treatment of children in the emergency department and are very stressful for the children, their parents and healthcare providers. Pharmacological methods to safely provide almost painless local anaesthesia, analgesia and anxiolysis have been increasingly studied in children. With knowledge of these methods, and patience, the emergency care provider can greatly reduce the distress often associated with emergency care of children.
Topical local anaesthetics such as LET [lidocaine (lignocaine), epinephrine (adrenaline), tetracaine] or buffered lidocaine injected through the wound with fine needles can almost painlessly anaesthetise lacerations for suturing. Topical creams such as lidocaine/prilocaine (EMLA®) or tetracaine, iontophoresed lidocaine, or buffered lidocaine subcutaneously injected with fine needles can make intravenous catheter placement virtually ‘painless’. When anxiety is significant, and mild to moderate analgesia/anxiolysis/amnesia is needed, nitrous oxide can be administered if the proper delivery devices are available. Alternatively, when intensely painful fracture reduction, burn debridement, or abscess drainage is necessary, well tolerated and effective deep sedation can be achieved with careful use of midazolam and either ketamine or fentanyl.
Literatur
1.
Zurück zum Zitat Carr DB, Jacox AK, Chapman CR, et al. Acute pain management: operative or medical procedures and trauma. Rockville (MD): AHCPR Publication, 1992 Feb. Clinical practice guideline No. 1:92-0032 Carr DB, Jacox AK, Chapman CR, et al. Acute pain management: operative or medical procedures and trauma. Rockville (MD): AHCPR Publication, 1992 Feb. Clinical practice guideline No. 1:92-0032
2.
Zurück zum Zitat Schechter NL, Berde CB, Yaster M. Pain in infants, children, and adolescents. Baltimore (MD): Williams & Wilkins, 1993 Schechter NL, Berde CB, Yaster M. Pain in infants, children, and adolescents. Baltimore (MD): Williams & Wilkins, 1993
3.
Zurück zum Zitat Terndrup TE. Pediatric pain control. Ann Emerg Med 1996; 27: 466–70PubMed Terndrup TE. Pediatric pain control. Ann Emerg Med 1996; 27: 466–70PubMed
4.
Zurück zum Zitat Walco GA, Cassidy RC, Schechter NL. Pain, hurt, and harm: the ethics of pain control in infants and children. N Engl J Med 1994; 331: 541–4PubMed Walco GA, Cassidy RC, Schechter NL. Pain, hurt, and harm: the ethics of pain control in infants and children. N Engl J Med 1994; 331: 541–4PubMed
5.
Zurück zum Zitat Weisman SJ, Bernstein B, Schechter NL. Consequences of inadequate analgesia during painful procedures in children. Arch Pediatr Adolesc Med 1998; 152: 147–9PubMed Weisman SJ, Bernstein B, Schechter NL. Consequences of inadequate analgesia during painful procedures in children. Arch Pediatr Adolesc Med 1998; 152: 147–9PubMed
6.
Zurück zum Zitat Zeltzer LK, Altman A, Cohen DM, et al. Report of the subcommittee on the management of pain associated with procedures in children with cancer. Pediatrics 1990; 86Suppl. 2: 826–34PubMed Zeltzer LK, Altman A, Cohen DM, et al. Report of the subcommittee on the management of pain associated with procedures in children with cancer. Pediatrics 1990; 86Suppl. 2: 826–34PubMed
7.
Zurück zum Zitat Committee on Drugs, American Academy of Pediatrics. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures. Pediatrics 1992; 89: 1110–5 Committee on Drugs, American Academy of Pediatrics. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures. Pediatrics 1992; 89: 1110–5
8.
Zurück zum Zitat Kennedy RM, Porter FL, Miller JP, et al. Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics 1998; 102: 956–63PubMed Kennedy RM, Porter FL, Miller JP, et al. Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics 1998; 102: 956–63PubMed
9.
Zurück zum Zitat Pace S, Burke TF. Intravenous morphine for early pain relief in patients with acute abdominal pain. Acad Emerg Med 1996; 3: 1086–92PubMed Pace S, Burke TF. Intravenous morphine for early pain relief in patients with acute abdominal pain. Acad Emerg Med 1996; 3: 1086–92PubMed
10.
Zurück zum Zitat Luhmann JD, Kennedy RM, Porter FL, et al. Nitrous oxide regimens more effective than midazolam for reducing distress during laceration repair in young children [abstract]. Pediatr Res 1998; 43: 383A Luhmann JD, Kennedy RM, Porter FL, et al. Nitrous oxide regimens more effective than midazolam for reducing distress during laceration repair in young children [abstract]. Pediatr Res 1998; 43: 383A
11.
Zurück zum Zitat Dollfus C, Annequin M, Adam M, et al. Analgesia with nitrous oxide for painful procedures in pediatric hematology-oncology. Ann Pediatr 1995; 42: 115–21 Dollfus C, Annequin M, Adam M, et al. Analgesia with nitrous oxide for painful procedures in pediatric hematology-oncology. Ann Pediatr 1995; 42: 115–21
12.
Zurück zum Zitat Selbst SM. Analgesia in children: why is it underused in emergency departments? Drug Saf 1992; 7: 8–13PubMed Selbst SM. Analgesia in children: why is it underused in emergency departments? Drug Saf 1992; 7: 8–13PubMed
13.
Zurück zum Zitat Friedland LR, Pancioli AM, Duncan KM. Pediatric emergency department analgesic practice. Pediatr Emerg Care 1997; 13: 103–6PubMed Friedland LR, Pancioli AM, Duncan KM. Pediatric emergency department analgesic practice. Pediatr Emerg Care 1997; 13: 103–6PubMed
14.
Zurück zum Zitat Krauss B, Zurakowski D. Sedation patterns in pediatric and general community hospital emergency departments. Pediatr Emerg Care 1998; 14: 99–103PubMed Krauss B, Zurakowski D. Sedation patterns in pediatric and general community hospital emergency departments. Pediatr Emerg Care 1998; 14: 99–103PubMed
15.
Zurück zum Zitat Pierluishi GJ, Terndrup TE. Influence of topical anesthesia on the sedation of pediatric emergency department patients with lacerations. Pediatr Emerg Care 1989; 5: 211–5 Pierluishi GJ, Terndrup TE. Influence of topical anesthesia on the sedation of pediatric emergency department patients with lacerations. Pediatr Emerg Care 1989; 5: 211–5
16.
17.
Zurück zum Zitat Ernst AA, Marvez E, Nick TG, et al. Lidocaine adrenaline tetracaine gel versus tetracaine adrenaline cocaine gel for topical anesthesia in linear scalp and facial lacerations in children aged 5 to 17 years. Pediatrics 1995; 95: 255–8PubMed Ernst AA, Marvez E, Nick TG, et al. Lidocaine adrenaline tetracaine gel versus tetracaine adrenaline cocaine gel for topical anesthesia in linear scalp and facial lacerations in children aged 5 to 17 years. Pediatrics 1995; 95: 255–8PubMed
18.
Zurück zum Zitat Schiling CG, Bank DE, Borchert BA, et al. Tetracaine, epinephrine (adrenalin), and cocaine (TAC) versus lidocaine, epinephrine, and tetracaine (LET) for anesthesia of lacerations in children. Ann Emerg Med 1995; 25: 203–8 Schiling CG, Bank DE, Borchert BA, et al. Tetracaine, epinephrine (adrenalin), and cocaine (TAC) versus lidocaine, epinephrine, and tetracaine (LET) for anesthesia of lacerations in children. Ann Emerg Med 1995; 25: 203–8
19.
Zurück zum Zitat Bonadio W. Safe and effective method for application of tetracaine, adrenaline, and cocaine to oral lacerations. Ann Emerg Med 1996; 28: 396–8PubMed Bonadio W. Safe and effective method for application of tetracaine, adrenaline, and cocaine to oral lacerations. Ann Emerg Med 1996; 28: 396–8PubMed
20.
Zurück zum Zitat Dailey RH. Fatality secondary to misuse of TAC solution. Ann Emerg Med 1988; 17: 159–60PubMed Dailey RH. Fatality secondary to misuse of TAC solution. Ann Emerg Med 1988; 17: 159–60PubMed
21.
Zurück zum Zitat Wehner D, Hamilton GC. Seizures following topical application of local anesthetics to burn patients. Ann Emerg Med 1984; 13: 456–8PubMed Wehner D, Hamilton GC. Seizures following topical application of local anesthetics to burn patients. Ann Emerg Med 1984; 13: 456–8PubMed
22.
Zurück zum Zitat Gajraj NM, Pennant JH, Watcha MF. Eutectic mixture of local anesthetics (EMLA®) cream. Anesth Analg 1994; 78: 574–83PubMed Gajraj NM, Pennant JH, Watcha MF. Eutectic mixture of local anesthetics (EMLA®) cream. Anesth Analg 1994; 78: 574–83PubMed
23.
Zurück zum Zitat Bjerring P, Arendt-Nielsen L. Depth and duration of skin analgesia to needle insertion after topical application of EMLA® cream. Br J Anaesth 1990; 64: 173–7PubMed Bjerring P, Arendt-Nielsen L. Depth and duration of skin analgesia to needle insertion after topical application of EMLA® cream. Br J Anaesth 1990; 64: 173–7PubMed
24.
Zurück zum Zitat Michael A, Andrew M. The application of EMLA® and glyceryl trinitrate ointment prior to venepuncture. Anaesth Intensive Care 1996; 24: 360–4PubMed Michael A, Andrew M. The application of EMLA® and glyceryl trinitrate ointment prior to venepuncture. Anaesth Intensive Care 1996; 24: 360–4PubMed
25.
Zurück zum Zitat Teillol-Foo WLM, Kassab JY. Topical glycerl trinitrate and eutectic mixture of local anaesthetics in children. Anaesthesia 1991; 46: 881–4PubMed Teillol-Foo WLM, Kassab JY. Topical glycerl trinitrate and eutectic mixture of local anaesthetics in children. Anaesthesia 1991; 46: 881–4PubMed
26.
Zurück zum Zitat Doyle E, Freeman J, Im NT, et al. An evaluation of a new self-adhesive patch preparation of amethocaine for topical anaesthesia prior to venous cannulation in children. Anaesthesia 1993; 8: 1050–2 Doyle E, Freeman J, Im NT, et al. An evaluation of a new self-adhesive patch preparation of amethocaine for topical anaesthesia prior to venous cannulation in children. Anaesthesia 1993; 8: 1050–2
27.
Zurück zum Zitat Van Kan HJM, Egberts ACG, Rijnvos WPM, et al. Tetracaine versus lidocaine-prilocaine for preventing venipuncture-induced pain in children. Am J Health Syst Pharm 1997; 54: 388–92PubMed Van Kan HJM, Egberts ACG, Rijnvos WPM, et al. Tetracaine versus lidocaine-prilocaine for preventing venipuncture-induced pain in children. Am J Health Syst Pharm 1997; 54: 388–92PubMed
28.
Zurück zum Zitat Irsfeld S, Klement W, Lipfert P. Dermal anaesthesia: comparison of EMLA® cream with iontophoretic local anaesthesia. Br J Anaesth 1993; 71: 375–8PubMed Irsfeld S, Klement W, Lipfert P. Dermal anaesthesia: comparison of EMLA® cream with iontophoretic local anaesthesia. Br J Anaesth 1993; 71: 375–8PubMed
29.
Zurück zum Zitat Fradet C, McGrath PJ, Kay J, et al. A prospective survey of reactions to blood tests by children and adolescents. Pain 1990; 40: 53–60PubMed Fradet C, McGrath PJ, Kay J, et al. A prospective survey of reactions to blood tests by children and adolescents. Pain 1990; 40: 53–60PubMed
30.
Zurück zum Zitat Krause RS, Moscati R, Filice M, et al. The effect of injection speed on the pain of lidocaine infiltration. Acad Emerg Med 1997; 4: 1032–5PubMed Krause RS, Moscati R, Filice M, et al. The effect of injection speed on the pain of lidocaine infiltration. Acad Emerg Med 1997; 4: 1032–5PubMed
31.
Zurück zum Zitat Scarfone RJ, Jasani M, Gracely EJ. Pain of local anesthetics: rate of administration and buffering. Ann Emerg Med 1998; 31: 36–40PubMed Scarfone RJ, Jasani M, Gracely EJ. Pain of local anesthetics: rate of administration and buffering. Ann Emerg Med 1998; 31: 36–40PubMed
32.
Zurück zum Zitat Arndt KA, Burton C, Noe JM. Minimizing the pain of local anesthesia. Plast Reconstr Surg 1983; 72: 676–9PubMed Arndt KA, Burton C, Noe JM. Minimizing the pain of local anesthesia. Plast Reconstr Surg 1983; 72: 676–9PubMed
33.
Zurück zum Zitat Brogan GX, Giarrusso E, Hollander JE, et al. Comparison of plain, warmed, and buffered lidocaine for anesthesia of traumatic wounds. Ann Emerg Med 1995; 26: 121–5PubMed Brogan GX, Giarrusso E, Hollander JE, et al. Comparison of plain, warmed, and buffered lidocaine for anesthesia of traumatic wounds. Ann Emerg Med 1995; 26: 121–5PubMed
34.
Zurück zum Zitat Colaric KB, Overton DT, Moore K. Pain reduction in lidocaine administration through buffering and warming. Am J Emerg Med 1998; 16: 353–6PubMed Colaric KB, Overton DT, Moore K. Pain reduction in lidocaine administration through buffering and warming. Am J Emerg Med 1998; 16: 353–6PubMed
35.
Zurück zum Zitat Christoph RA, Buchanan L, Begalia K, et al. Pain reduction in local anesthetic administration through pH buffering. Ann Emerg Med 1988; 17: 117–20PubMed Christoph RA, Buchanan L, Begalia K, et al. Pain reduction in local anesthetic administration through pH buffering. Ann Emerg Med 1988; 17: 117–20PubMed
36.
Zurück zum Zitat McKay W, Morris R, Mushlin P. Sodium bicarbonate attenuates pain on skin infiltration with lidocaine, with or without epinephrine. Anesth Analg 1987; 66: 572–4PubMed McKay W, Morris R, Mushlin P. Sodium bicarbonate attenuates pain on skin infiltration with lidocaine, with or without epinephrine. Anesth Analg 1987; 66: 572–4PubMed
37.
Zurück zum Zitat Stanton-Hicks MD. Local anesthetics: pharmacology and clinical applications. Hosp Formul 1987; 22: 156–71 Stanton-Hicks MD. Local anesthetics: pharmacology and clinical applications. Hosp Formul 1987; 22: 156–71
38.
Zurück zum Zitat Bartfield JM, Homer PJ, Ford DT, et al. Buffered lidocaine as a local anesthetic: an investigation on shelf life. Ann Emerg Med 1991; 21: 16–9 Bartfield JM, Homer PJ, Ford DT, et al. Buffered lidocaine as a local anesthetic: an investigation on shelf life. Ann Emerg Med 1991; 21: 16–9
39.
Zurück zum Zitat Orlinsky M, Hudson C, Chan L, et al. Pain comparison of unbuffered versus buffered lidocaine in local wound infiltration. J Emerg Med 1992; 10: 411–5PubMed Orlinsky M, Hudson C, Chan L, et al. Pain comparison of unbuffered versus buffered lidocaine in local wound infiltration. J Emerg Med 1992; 10: 411–5PubMed
40.
Zurück zum Zitat Meyer G, Henneman PL. Buffered lidocaine [letter]. Ann Emerg Med 1991; 20: 218–9PubMed Meyer G, Henneman PL. Buffered lidocaine [letter]. Ann Emerg Med 1991; 20: 218–9PubMed
41.
Zurück zum Zitat Larson PO, Ragi G, Swandby M, et al. Stability of buffered lidocaine and epinephrine used for local anesthesia. J Dermatol Surg Oncol 1991; 7: 411–4 Larson PO, Ragi G, Swandby M, et al. Stability of buffered lidocaine and epinephrine used for local anesthesia. J Dermatol Surg Oncol 1991; 7: 411–4
42.
Zurück zum Zitat Task Force on Sedation and Analgesia by Non-Anesthesiologists, American Society of Anesthesiologists. Practice guidelines for sedation and analgesia by non-anesthesiologists. Anesthesiology 1996; 84: 459–71 Task Force on Sedation and Analgesia by Non-Anesthesiologists, American Society of Anesthesiologists. Practice guidelines for sedation and analgesia by non-anesthesiologists. Anesthesiology 1996; 84: 459–71
43.
Zurück zum Zitat Maxwell LG, Yaster M. The myth of conscious sedation. Arch Pediatr Adolesc Med 1996; 150: 665–7PubMed Maxwell LG, Yaster M. The myth of conscious sedation. Arch Pediatr Adolesc Med 1996; 150: 665–7PubMed
44.
Zurück zum Zitat Yaster M, Nichols DG, Deshpande JK, et al. Midazolam-fentanyl intravenous sedation in children: case report of respiratory arrest. Pediatrics 1990; 86: 463–7PubMed Yaster M, Nichols DG, Deshpande JK, et al. Midazolam-fentanyl intravenous sedation in children: case report of respiratory arrest. Pediatrics 1990; 86: 463–7PubMed
45.
Zurück zum Zitat Schreiner MS. Preoperative and postoperative fasting in children. Pediatr Clin North Am 1994; 41: 111–20PubMed Schreiner MS. Preoperative and postoperative fasting in children. Pediatr Clin North Am 1994; 41: 111–20PubMed
46.
Zurück zum Zitat Warner MA, Warner ME, Warner DO, et al. Perioperative pulmonary aspiration in infants and children. Anesthesiology 1999; 90: 66–71PubMed Warner MA, Warner ME, Warner DO, et al. Perioperative pulmonary aspiration in infants and children. Anesthesiology 1999; 90: 66–71PubMed
47.
Zurück zum Zitat Graff KJ, Kennedy RM, Jaffe DM. Conscious sedation for pediatric orthopaedic emergencies. Pediatr Emerg Care 1996; 12: 31–5PubMed Graff KJ, Kennedy RM, Jaffe DM. Conscious sedation for pediatric orthopaedic emergencies. Pediatr Emerg Care 1996; 12: 31–5PubMed
48.
Zurück zum Zitat Green SM, Rothrock SG, Lynch EL, et al. Intramuscular ketamine for pediatric sedation in the emergency department: safety profile in 1,022 cases. Ann Emerg Med 1998; 31: 688–97PubMed Green SM, Rothrock SG, Lynch EL, et al. Intramuscular ketamine for pediatric sedation in the emergency department: safety profile in 1,022 cases. Ann Emerg Med 1998; 31: 688–97PubMed
49.
Zurück zum Zitat Pena BMG, Krauss B. Adverse events of procedural sedation and analgesia in a pediatric emergency department. Ann Emerg Med 1999; 34: 483–91PubMed Pena BMG, Krauss B. Adverse events of procedural sedation and analgesia in a pediatric emergency department. Ann Emerg Med 1999; 34: 483–91PubMed
50.
Zurück zum Zitat Strain JD, Harvey LA, Foley LC, et al. Intravenously administered pentobarbital sodium for sedation in pediatric CT. Radiology 1986; 161: 105–8PubMed Strain JD, Harvey LA, Foley LC, et al. Intravenously administered pentobarbital sodium for sedation in pediatric CT. Radiology 1986; 161: 105–8PubMed
51.
Zurück zum Zitat Sanderson PM. A survey of pentobarbital sedation for children undergoing abdominal CT scans after oral contrast medium. Paediatr Anaesth 1997; 7: 309–15PubMed Sanderson PM. A survey of pentobarbital sedation for children undergoing abdominal CT scans after oral contrast medium. Paediatr Anaesth 1997; 7: 309–15PubMed
52.
Zurück zum Zitat Fassler D, Wallace N. Children’s fear of needles. Clin Pediatr 1982; 21: 59–60 Fassler D, Wallace N. Children’s fear of needles. Clin Pediatr 1982; 21: 59–60
53.
Zurück zum Zitat Humphrey GB, Boon CM, van den Heuvell GF, et al. The occurrence of high levels of acute behavioral distress in children and adolescents undergoing routine venipunctures. Pediatrics 1992; 90: 87–91PubMed Humphrey GB, Boon CM, van den Heuvell GF, et al. The occurrence of high levels of acute behavioral distress in children and adolescents undergoing routine venipunctures. Pediatrics 1992; 90: 87–91PubMed
54.
Zurück zum Zitat Lewis N. The needle is like an animal: how children view injections. Child Today 1978; 7: 18–21PubMed Lewis N. The needle is like an animal: how children view injections. Child Today 1978; 7: 18–21PubMed
55.
Zurück zum Zitat Rice LJ. Needle phobia: an anesthesiologist’s perspective. J Pediatr 1993; 122 (5 Pt 2): S9–13PubMed Rice LJ. Needle phobia: an anesthesiologist’s perspective. J Pediatr 1993; 122 (5 Pt 2): S9–13PubMed
56.
Zurück zum Zitat Eland JM, Anderson JE. The experience of pain in children. In: Jacox A, editor. A source book for nurses and other health professionals. Boston (MA): Little, Brown, 1977: 453–76 Eland JM, Anderson JE. The experience of pain in children. In: Jacox A, editor. A source book for nurses and other health professionals. Boston (MA): Little, Brown, 1977: 453–76
57.
Zurück zum Zitat Dennis AR, Leeson-Payne CG, Langham BT, et al. Local anesthesia for cannulation: has practice changed? Anaesthesia 1995; 50: 400–2PubMed Dennis AR, Leeson-Payne CG, Langham BT, et al. Local anesthesia for cannulation: has practice changed? Anaesthesia 1995; 50: 400–2PubMed
58.
Zurück zum Zitat Klein EJ, Shugerman RP, Leigh-Taylor K, et al. Buffered lidocaine: analgesia for intravenous line placement in children. Pediatrics 1995; 95: 709–12PubMed Klein EJ, Shugerman RP, Leigh-Taylor K, et al. Buffered lidocaine: analgesia for intravenous line placement in children. Pediatrics 1995; 95: 709–12PubMed
59.
Zurück zum Zitat Sacchetti A, Carraccio C. Subcutaneous lidocaine does not affect the success rate of intravenous access in children less than 24 months of age. Acad Emerg Med 1996; 3: 1016–9PubMed Sacchetti A, Carraccio C. Subcutaneous lidocaine does not affect the success rate of intravenous access in children less than 24 months of age. Acad Emerg Med 1996; 3: 1016–9PubMed
60.
Zurück zum Zitat Wolfram RW, Turner ED. Effects of parental presence during children’s venipuncture. Acad Emerg Med 1996; 3: 58–64PubMed Wolfram RW, Turner ED. Effects of parental presence during children’s venipuncture. Acad Emerg Med 1996; 3: 58–64PubMed
61.
Zurück zum Zitat Bauchner H, Vinci R, Bak S, et al. Parents and procedures: a randomized controlled trial. Pediatrics 1996; 98: 861–7PubMed Bauchner H, Vinci R, Bak S, et al. Parents and procedures: a randomized controlled trial. Pediatrics 1996; 98: 861–7PubMed
62.
Zurück zum Zitat Wolfram RW, Turner ED, Philput C. Effects of parental presence during young children’s venipuncture. Pediatr Emerg Care 1997; 13: 325–8PubMed Wolfram RW, Turner ED, Philput C. Effects of parental presence during young children’s venipuncture. Pediatr Emerg Care 1997; 13: 325–8PubMed
63.
Zurück zum Zitat Fernald CD, Corry JJ. Emphatic versus directive preparation of children for needles. Child Health Care 1981; 10: 44–7PubMed Fernald CD, Corry JJ. Emphatic versus directive preparation of children for needles. Child Health Care 1981; 10: 44–7PubMed
64.
Zurück zum Zitat Maunuksela EL, Korpela R. Double-blind evaluation of a lignocaine-prilocaine cream (EMLA®) in children. Br J Anaesth 1986; 58: 1242–5PubMed Maunuksela EL, Korpela R. Double-blind evaluation of a lignocaine-prilocaine cream (EMLA®) in children. Br J Anaesth 1986; 58: 1242–5PubMed
65.
Zurück zum Zitat Arts SE, Abu-Saad HH, Champion GD, et al. Age-related response to lidocaine-prilocaine (EMLA®) emulsion and effect of music distraction on the pain of intravenous cannulation. Pediatrics 1994; 93: 797–801PubMed Arts SE, Abu-Saad HH, Champion GD, et al. Age-related response to lidocaine-prilocaine (EMLA®) emulsion and effect of music distraction on the pain of intravenous cannulation. Pediatrics 1994; 93: 797–801PubMed
66.
Zurück zum Zitat Lawson RA, Smart NG, Gudgeon AC, et al. Evaluation of an amethocaine (tetracaine) gel preparation for percutaneous analgesia before venous cannulation in children. Br J Anaesth 1995; 75: 282–5PubMed Lawson RA, Smart NG, Gudgeon AC, et al. Evaluation of an amethocaine (tetracaine) gel preparation for percutaneous analgesia before venous cannulation in children. Br J Anaesth 1995; 75: 282–5PubMed
67.
Zurück zum Zitat Zempsky WT, Anand KJS, Sullivan KM, et al. Lidocaine iontophoresis for topical anesthesia before intravenous line placement in children. J Pediatr 1998; 132: 1061–3PubMed Zempsky WT, Anand KJS, Sullivan KM, et al. Lidocaine iontophoresis for topical anesthesia before intravenous line placement in children. J Pediatr 1998; 132: 1061–3PubMed
68.
Zurück zum Zitat Soliman IE, Broadman LM, Hannallah RS, et al. Comparison of the analgesic effects of EMLA® to intradermal lidocaine infiltration prior to venous cannulation in unpremedicated children. Anesthesiology 1988; 68: 804–6PubMed Soliman IE, Broadman LM, Hannallah RS, et al. Comparison of the analgesic effects of EMLA® to intradermal lidocaine infiltration prior to venous cannulation in unpremedicated children. Anesthesiology 1988; 68: 804–6PubMed
69.
Zurück zum Zitat Fein JA, Boardman CR, Stevenson S, et al. Saline with benzyl alcohol as intradermal anesthesia for intravenous line placement in children. Pediatr Emerg Care 1998; 14: 119–22PubMed Fein JA, Boardman CR, Stevenson S, et al. Saline with benzyl alcohol as intradermal anesthesia for intravenous line placement in children. Pediatr Emerg Care 1998; 14: 119–22PubMed
70.
Zurück zum Zitat Luhmann JD, Shootman M, Kennedy RM. Making ivs ouch-less: buffered lidocaine versus benzyl alcohol [abstract]. Ped Res 2000; 47: 113A Luhmann JD, Shootman M, Kennedy RM. Making ivs ouch-less: buffered lidocaine versus benzyl alcohol [abstract]. Ped Res 2000; 47: 113A
71.
Zurück zum Zitat Henderson JM, Spence DG, Komocar LM, et al. Administration of nitrous oxide to pediatric patients provides analgesia for venous cannulation. Anesthesiology 1990; 72: 269–71PubMed Henderson JM, Spence DG, Komocar LM, et al. Administration of nitrous oxide to pediatric patients provides analgesia for venous cannulation. Anesthesiology 1990; 72: 269–71PubMed
72.
Zurück zum Zitat Vetter TR. A comparison of EMLA® crean versus nitrous oxide for pediatric venous cannulation. J Clin Anesth 1995; 7: 486–90PubMed Vetter TR. A comparison of EMLA® crean versus nitrous oxide for pediatric venous cannulation. J Clin Anesth 1995; 7: 486–90PubMed
73.
Zurück zum Zitat Brislin RP, Stayer SA, Schwartz RE, et al. Analgesia for venepuncture in a paediatric surgery centre. J Pediatr Child Health 1995; 31: 542–4 Brislin RP, Stayer SA, Schwartz RE, et al. Analgesia for venepuncture in a paediatric surgery centre. J Pediatr Child Health 1995; 31: 542–4
74.
Zurück zum Zitat Kennedy RM, Luhmann JD. The ouchless emergency department. Getting closer. Advances in decreasing distress during painful procedures in the emergency department. Pediatr Clin North Am 1999; 46: 1215–47PubMed Kennedy RM, Luhmann JD. The ouchless emergency department. Getting closer. Advances in decreasing distress during painful procedures in the emergency department. Pediatr Clin North Am 1999; 46: 1215–47PubMed
75.
Zurück zum Zitat Burton JH, Auble TE, Fuchs SM. Effectiveness of 50% nitrous oxide/50% oxygen during laceration repair in children. Acad Emerg Med 1998; 5: 112–7PubMed Burton JH, Auble TE, Fuchs SM. Effectiveness of 50% nitrous oxide/50% oxygen during laceration repair in children. Acad Emerg Med 1998; 5: 112–7PubMed
76.
Zurück zum Zitat Fatovich DM, Jacobs IG. A randomized, controlled trial of oral midazolam and buffered lidocaine for suturing lacerations in children (the SLIC Trial). Ann Emerg Med 1995; 25: 209–14PubMed Fatovich DM, Jacobs IG. A randomized, controlled trial of oral midazolam and buffered lidocaine for suturing lacerations in children (the SLIC Trial). Ann Emerg Med 1995; 25: 209–14PubMed
77.
Zurück zum Zitat Qureshi FA, Mellis PT, McFadden MA. Efficacy of oral ketamine for providing sedation and analgesia to children requiring laceration repair. Pediatr Emerg Care 1995; 11: 93–7PubMed Qureshi FA, Mellis PT, McFadden MA. Efficacy of oral ketamine for providing sedation and analgesia to children requiring laceration repair. Pediatr Emerg Care 1995; 11: 93–7PubMed
78.
Zurück zum Zitat Yamamoto LG, Young LL, Roberts JL. Informed consent and parental choice of anesthesia and sedation for the repair of small lacerations in children. Am J Emerg Med 1997; 15: 285–9PubMed Yamamoto LG, Young LL, Roberts JL. Informed consent and parental choice of anesthesia and sedation for the repair of small lacerations in children. Am J Emerg Med 1997; 15: 285–9PubMed
79.
Zurück zum Zitat Bruns TB, Simon HK, McLario DJ, et al. Laceration repair using a tissue adhesive in a children’s emergency department. Pediatrics 1996; 98: 673–5PubMed Bruns TB, Simon HK, McLario DJ, et al. Laceration repair using a tissue adhesive in a children’s emergency department. Pediatrics 1996; 98: 673–5PubMed
80.
Zurück zum Zitat Bruns TB, Robinson BS, Smith RJ, et al. A new tissue adhesive for laceration repair in children. J Pediatr 1998; 132: 1067–70PubMed Bruns TB, Robinson BS, Smith RJ, et al. A new tissue adhesive for laceration repair in children. J Pediatr 1998; 132: 1067–70PubMed
81.
Zurück zum Zitat Simon HK, McLario DJ, Bruns TJ, et al. Long-term appearance of lacerations repaired using a tissue adhesive. Pediatrics 1997; 99: 193–5PubMed Simon HK, McLario DJ, Bruns TJ, et al. Long-term appearance of lacerations repaired using a tissue adhesive. Pediatrics 1997; 99: 193–5PubMed
82.
Zurück zum Zitat Zempsky WT, Karasic RB. EMLA® versus TAC for topical anesthesia of extremity wounds in children. Ann Emerg Med 1997; 30: 163–6PubMed Zempsky WT, Karasic RB. EMLA® versus TAC for topical anesthesia of extremity wounds in children. Ann Emerg Med 1997; 30: 163–6PubMed
83.
Zurück zum Zitat Bartfield JM, Sokaris SJ, Raccio-Robak N. Local anesthesia for lacerations: pain of infiltration inside vs outside the wound. Acad Emerg Med 1998; 5: 100–4PubMed Bartfield JM, Sokaris SJ, Raccio-Robak N. Local anesthesia for lacerations: pain of infiltration inside vs outside the wound. Acad Emerg Med 1998; 5: 100–4PubMed
84.
Zurück zum Zitat Trott A. Wounds and lacerations: emergency care and closure. 2nd ed. St Louis (MO): Mosby, 1999 Trott A. Wounds and lacerations: emergency care and closure. 2nd ed. St Louis (MO): Mosby, 1999
85.
Zurück zum Zitat Ghoneim MM, Mewaldt SP. Benzodiazepines and human memory: a review. Anesthesiology 1990; 2: 926–38 Ghoneim MM, Mewaldt SP. Benzodiazepines and human memory: a review. Anesthesiology 1990; 2: 926–38
86.
Zurück zum Zitat Ramoska EA, Linkenheimer R, Glasgow C. Midazolam use in the emergency department. J Emerg Med 1991; 9: 247–51PubMed Ramoska EA, Linkenheimer R, Glasgow C. Midazolam use in the emergency department. J Emerg Med 1991; 9: 247–51PubMed
87.
Zurück zum Zitat Wright SW, Chudnofsky CR, Dronen SC, et al. Comparison of midazolam and diazepam for conscious sedation in the emergency department. Ann Emerg Med 1993; 201–5 Wright SW, Chudnofsky CR, Dronen SC, et al. Comparison of midazolam and diazepam for conscious sedation in the emergency department. Ann Emerg Med 1993; 201–5
88.
Zurück zum Zitat Hennes HM, Wagner V, Bonadio W, et al. The effect of oral midazolam on anxiety of preschool children during laceration repair. Ann Emerg Med 1990; 19: 1006–9PubMed Hennes HM, Wagner V, Bonadio W, et al. The effect of oral midazolam on anxiety of preschool children during laceration repair. Ann Emerg Med 1990; 19: 1006–9PubMed
89.
Zurück zum Zitat Connors K, Terndrup TE. Nasal versus oral midazolam for sedation of anxious children undergoing laceration repair. Ann Emerg Med 1994; 24: 1074–9PubMed Connors K, Terndrup TE. Nasal versus oral midazolam for sedation of anxious children undergoing laceration repair. Ann Emerg Med 1994; 24: 1074–9PubMed
90.
Zurück zum Zitat Shane SA, Fuchs SM, Khine H. Efficacy of rectal midazolam for the sedation of preschool children undergoing laceration repair. Ann Emerg Med 1994; 24: 1065–73PubMed Shane SA, Fuchs SM, Khine H. Efficacy of rectal midazolam for the sedation of preschool children undergoing laceration repair. Ann Emerg Med 1994; 24: 1065–73PubMed
91.
Zurück zum Zitat Doyle WL, Perrin L. Emergence delirium in a child given oral midazolam for conscious sedation. Ann Emerg Med 1994; 24: 1173–5PubMed Doyle WL, Perrin L. Emergence delirium in a child given oral midazolam for conscious sedation. Ann Emerg Med 1994; 24: 1173–5PubMed
92.
Zurück zum Zitat Schechter NL, Weisman SJ, Rosenblum M, et al. The use of oral transmucosal fentanyl citrate for painful procedures in children. Pediatrics 1995; 95: 335–9PubMed Schechter NL, Weisman SJ, Rosenblum M, et al. The use of oral transmucosal fentanyl citrate for painful procedures in children. Pediatrics 1995; 95: 335–9PubMed
93.
Zurück zum Zitat Schutzman SA, Burg J, Liebelt E, et al. Oral transmucosal fentanyl citrate for premedication of children undergoing laceration repair. Ann Emerg Med 1994; 24: 1059–64PubMed Schutzman SA, Burg J, Liebelt E, et al. Oral transmucosal fentanyl citrate for premedication of children undergoing laceration repair. Ann Emerg Med 1994; 24: 1059–64PubMed
94.
Zurück zum Zitat Schutzman SA, Liebelt E, Wisk M, et al. Comparison of oral transmucosal fentanyl citrate and intramuscular meperidine, promethazine, and chlorpromazine for conscious sedation of children undergoing laceration repair. Ann Emerg Med 1996: 18: 385–90 Schutzman SA, Liebelt E, Wisk M, et al. Comparison of oral transmucosal fentanyl citrate and intramuscular meperidine, promethazine, and chlorpromazine for conscious sedation of children undergoing laceration repair. Ann Emerg Med 1996: 18: 385–90
95.
Zurück zum Zitat Bates BA, Schutzman SA, Fleisher GR. A comparison of intranasal sufentanil and midazolam to intramuscular meperidine, promethazine, and chlorparomazine for conscious sedation in children. Ann Emerg Med 1994; 24: 646–51PubMed Bates BA, Schutzman SA, Fleisher GR. A comparison of intranasal sufentanil and midazolam to intramuscular meperidine, promethazine, and chlorparomazine for conscious sedation in children. Ann Emerg Med 1994; 24: 646–51PubMed
96.
Zurück zum Zitat Gutstein HB, Johnson KL, Heard MB, et al. Oral ketamine preanesthetic medication in children. Anesthesiology 1992; 76: 28–33PubMed Gutstein HB, Johnson KL, Heard MB, et al. Oral ketamine preanesthetic medication in children. Anesthesiology 1992; 76: 28–33PubMed
97.
Zurück zum Zitat Tobias JD, Phipps S, Smith B, et al. Oral ketamine premedication to alleviate the distress of invasive procedures in pediatric oncology patients. Pediatrics 1992; 90: 537–41PubMed Tobias JD, Phipps S, Smith B, et al. Oral ketamine premedication to alleviate the distress of invasive procedures in pediatric oncology patients. Pediatrics 1992; 90: 537–41PubMed
98.
Zurück zum Zitat Luhmann JD, Kennedy RM, Porter FL, et al. A randomized clinical trial of continuous-flow nitrous oxide and midazolam for sedation of young children during laceration repair. Ann Emerg Med 2001; 37(1): 20–7PubMed Luhmann JD, Kennedy RM, Porter FL, et al. A randomized clinical trial of continuous-flow nitrous oxide and midazolam for sedation of young children during laceration repair. Ann Emerg Med 2001; 37(1): 20–7PubMed
99.
Zurück zum Zitat Gamis AS, Knapp JF, Glenski JA. Nitrous oxide analgesia in a pediatric emergency department. Ann Emerg Med 1989; 18: 177–81PubMed Gamis AS, Knapp JF, Glenski JA. Nitrous oxide analgesia in a pediatric emergency department. Ann Emerg Med 1989; 18: 177–81PubMed
100.
Zurück zum Zitat Luhmann JD, Kennedy RM, Jaffe DM, et al. Continuous flow delivery of nitrous oxide and oxygen: a safe and cost effective technique for inhalation analgesia and sedation of pediatric patients. Pediatr Emerg Care 1999; 15: 388–92PubMed Luhmann JD, Kennedy RM, Jaffe DM, et al. Continuous flow delivery of nitrous oxide and oxygen: a safe and cost effective technique for inhalation analgesia and sedation of pediatric patients. Pediatr Emerg Care 1999; 15: 388–92PubMed
101.
Zurück zum Zitat Quinn M, Carraccio C, Sacchetti A. Pain, punctures, and pediatricians. Pediatr Emerg Care 1993; 9: 12–4PubMed Quinn M, Carraccio C, Sacchetti A. Pain, punctures, and pediatricians. Pediatr Emerg Care 1993; 9: 12–4PubMed
102.
Zurück zum Zitat McGrath PJ, McAlpine L. Psychologic perspectives on pediatric pain. J Pediatr 1993; 122 (5 Pt 2): S2–8PubMed McGrath PJ, McAlpine L. Psychologic perspectives on pediatric pain. J Pediatr 1993; 122 (5 Pt 2): S2–8PubMed
103.
Zurück zum Zitat Pinheiro JM, Furdon S, Ochoa LF. Role of local anesthesia during lumbar puncture in neonates. Pediatrics 1993; 91:379–82PubMed Pinheiro JM, Furdon S, Ochoa LF. Role of local anesthesia during lumbar puncture in neonates. Pediatrics 1993; 91:379–82PubMed
104.
Zurück zum Zitat Porter FL, Miller JP, Cole FS, et al. A controlled trial of local anesthesia for lumbar punctures in newborns. Pediatrics 1991; 88: 663–9PubMed Porter FL, Miller JP, Cole FS, et al. A controlled trial of local anesthesia for lumbar punctures in newborns. Pediatrics 1991; 88: 663–9PubMed
105.
Zurück zum Zitat Gimenez JC, Oliveras M, Hidalgo E, et al. Anesthetic efficacy of eutectic prilocaine-lidocaine cream in pediatric oncology patients undergoing lumbar puncture. Ann Pharmacother 1996; 30: 1235–7 Gimenez JC, Oliveras M, Hidalgo E, et al. Anesthetic efficacy of eutectic prilocaine-lidocaine cream in pediatric oncology patients undergoing lumbar puncture. Ann Pharmacother 1996; 30: 1235–7
106.
Zurück zum Zitat Kapelushnik J, Koren G, Solh H, et al. Evaluating the efficacy of EMLA® in alleviating pain associated with lumbar puncture: comparison of open and double-blinded protocols in children. Pain 1990; 42: 31–4PubMed Kapelushnik J, Koren G, Solh H, et al. Evaluating the efficacy of EMLA® in alleviating pain associated with lumbar puncture: comparison of open and double-blinded protocols in children. Pain 1990; 42: 31–4PubMed
107.
Zurück zum Zitat Freyer DR, Schwanda AE, Dominic JS, et al. Intravenous methohexital for brief sedation of pediatric oncology outpatients: physiologic and behavioral responses. Pediatrics 1997; 99: E8PubMed Freyer DR, Schwanda AE, Dominic JS, et al. Intravenous methohexital for brief sedation of pediatric oncology outpatients: physiologic and behavioral responses. Pediatrics 1997; 99: E8PubMed
108.
Zurück zum Zitat Friedman AG, Mulhern RK, Fairclough D, et al. Midazolam premedication for pediatric bone marrow aspiration and lumbar puncture. Med Pediatr Oncol 1991; 19: 499–504PubMed Friedman AG, Mulhern RK, Fairclough D, et al. Midazolam premedication for pediatric bone marrow aspiration and lumbar puncture. Med Pediatr Oncol 1991; 19: 499–504PubMed
109.
Zurück zum Zitat Committee on Drugs, American Academy of Pediatrics. Reappraisal of lytic cocktail/demerol, phenergan, and thorazine (DPT) for the sedation of children. Pediatrics 1995; 95:598–602 Committee on Drugs, American Academy of Pediatrics. Reappraisal of lytic cocktail/demerol, phenergan, and thorazine (DPT) for the sedation of children. Pediatrics 1995; 95:598–602
110.
Zurück zum Zitat Hennrikus WL, Shin AY, Klingelberger CE. Self-administered nitrous oxide and a hematoma block for analgesia in the outpatient reduction of fractures in children. J Bone Joint Surg Am 1995; 77: 335–9PubMed Hennrikus WL, Shin AY, Klingelberger CE. Self-administered nitrous oxide and a hematoma block for analgesia in the outpatient reduction of fractures in children. J Bone Joint Surg Am 1995; 77: 335–9PubMed
111.
Zurück zum Zitat Meinig RP, Quick A, Lobmeyer L. Plasma lidocaine levels following hematoma block for distal radius fractures. J Orthop Trauma 1989; 3: 187–91PubMed Meinig RP, Quick A, Lobmeyer L. Plasma lidocaine levels following hematoma block for distal radius fractures. J Orthop Trauma 1989; 3: 187–91PubMed
112.
Zurück zum Zitat Bolte R, Stevens P, Scott S, et al. Mini-dose bier block intravenous regional anesthesia in emergency department treatment of pediatric upper-extremity injuries. J Pediatr Orthop 1994; 4: 534–7 Bolte R, Stevens P, Scott S, et al. Mini-dose bier block intravenous regional anesthesia in emergency department treatment of pediatric upper-extremity injuries. J Pediatr Orthop 1994; 4: 534–7
113.
Zurück zum Zitat Juliano PJ, Mazur JM, Cummings RJ, et al. Low-dose lidocaine intravenous regional anesthesia for forearm fractures in children. J Pediatr Orthop 1992; 12: 633–5PubMed Juliano PJ, Mazur JM, Cummings RJ, et al. Low-dose lidocaine intravenous regional anesthesia for forearm fractures in children. J Pediatr Orthop 1992; 12: 633–5PubMed
114.
Zurück zum Zitat Cramer KE, Glasson S, Mencio G, et al. Reduction of forearm fractures in children using axillary block anesthesia. J Orthop Trauma 1995; 9: 407–10PubMed Cramer KE, Glasson S, Mencio G, et al. Reduction of forearm fractures in children using axillary block anesthesia. J Orthop Trauma 1995; 9: 407–10PubMed
115.
Zurück zum Zitat Green S, Johnson NE. Ketamine sedation for pediatric procedures: part 2, review and implications. Ann Emerg Med 1990; 19: 1033–46PubMed Green S, Johnson NE. Ketamine sedation for pediatric procedures: part 2, review and implications. Ann Emerg Med 1990; 19: 1033–46PubMed
116.
Zurück zum Zitat White PF, Way WL, Trevor AJ. Ketamine: its pharmacology and therapeutic uses. Anesthesiology 1982; 56: 119–36PubMed White PF, Way WL, Trevor AJ. Ketamine: its pharmacology and therapeutic uses. Anesthesiology 1982; 56: 119–36PubMed
117.
Zurück zum Zitat Marx CM, Stein J, Tyler MK, et al. Ketamine-midazolam versus meperidine-midazolam for painful procedures in pediatric oncology patients. J Clin Oncol 1997; 15: 94–102PubMed Marx CM, Stein J, Tyler MK, et al. Ketamine-midazolam versus meperidine-midazolam for painful procedures in pediatric oncology patients. J Clin Oncol 1997; 15: 94–102PubMed
118.
Zurück zum Zitat Parker RI, Mahan RA, Giugliano D, et al. Efficacy and safety of intravenous midazolam and ketamine as sedation for therapeutic and diagnostic procedures in children. Pediatrics 1997; 99:427–31PubMed Parker RI, Mahan RA, Giugliano D, et al. Efficacy and safety of intravenous midazolam and ketamine as sedation for therapeutic and diagnostic procedures in children. Pediatrics 1997; 99:427–31PubMed
119.
Zurück zum Zitat McDowall RH, Scher CS, Barst SM. Total intravenous anesthesia for children undergoing brief diagnostic or therapeutic procedures. J Clin Anesth 1995; 7: 273–80PubMed McDowall RH, Scher CS, Barst SM. Total intravenous anesthesia for children undergoing brief diagnostic or therapeutic procedures. J Clin Anesth 1995; 7: 273–80PubMed
120.
Zurück zum Zitat Dachs RJ, Innes GM. Intravenous ketamine sedation of pediatric patients in the emergency department. Ann Emerg Med 1997; 29: 146–50PubMed Dachs RJ, Innes GM. Intravenous ketamine sedation of pediatric patients in the emergency department. Ann Emerg Med 1997; 29: 146–50PubMed
121.
Zurück zum Zitat Green SM, Nakamura R, Johnson NE. Ketamine sedation for pediatric procedures: part 1: a prospective series. Ann Emerg Med 1990; 19: 1024–32PubMed Green SM, Nakamura R, Johnson NE. Ketamine sedation for pediatric procedures: part 1: a prospective series. Ann Emerg Med 1990; 19: 1024–32PubMed
122.
Zurück zum Zitat Green SM, Kuppermann N, Rothrock SG. Predictors of adverse events with intramuscular ketamine sedation in children. Ann Emerg Med 2000; 35: 35–42PubMed Green SM, Kuppermann N, Rothrock SG. Predictors of adverse events with intramuscular ketamine sedation in children. Ann Emerg Med 2000; 35: 35–42PubMed
123.
Zurück zum Zitat Green SM, Hummel CB, Wittlake WA, et al. What is the optimal dose of intramuscular ketamine for pediatric sedation? Acad Emerg Med 1999; 6: 21–6PubMed Green SM, Hummel CB, Wittlake WA, et al. What is the optimal dose of intramuscular ketamine for pediatric sedation? Acad Emerg Med 1999; 6: 21–6PubMed
124.
Zurück zum Zitat Epstein FB. Ketamine dissociative sedation in pediatric emergency medical practice. Am J Emerg Med 1993; 11: 180–2PubMed Epstein FB. Ketamine dissociative sedation in pediatric emergency medical practice. Am J Emerg Med 1993; 11: 180–2PubMed
125.
Zurück zum Zitat Petrack EM, Marx CM, Wright MS. Intramuscular ketamine is superior to meperidine, promethazine, and chlorpromazine for pediatric emergency department sedation. Arch Pediatr Adolesc Med 1996; 150: 676–81PubMed Petrack EM, Marx CM, Wright MS. Intramuscular ketamine is superior to meperidine, promethazine, and chlorpromazine for pediatric emergency department sedation. Arch Pediatr Adolesc Med 1996; 150: 676–81PubMed
126.
Zurück zum Zitat Sherwin TS, Green SM, Khan A, et al. Does adjunctive midazolam reduce recovery agitation after ketamine sedation for pediatric procedures: a randomized, double-blind, placebo-controlled trial. Ann Emerg Med 2000; 35: 229–38PubMed Sherwin TS, Green SM, Khan A, et al. Does adjunctive midazolam reduce recovery agitation after ketamine sedation for pediatric procedures: a randomized, double-blind, placebo-controlled trial. Ann Emerg Med 2000; 35: 229–38PubMed
127.
Zurück zum Zitat Wathen JE, Roback MG, Mckenzie T, et al. Does midazolam alter the clinical effects of intravenous ketamine sedation in children? A double-blind, randomized, controlled, emergency department trial. Ann Emerg Med 2000; 36: 579–88PubMed Wathen JE, Roback MG, Mckenzie T, et al. Does midazolam alter the clinical effects of intravenous ketamine sedation in children? A double-blind, randomized, controlled, emergency department trial. Ann Emerg Med 2000; 36: 579–88PubMed
128.
Zurück zum Zitat Kennedy RM, McAllister JD. Midazolam with ketamine: who benefits? Ann Emerg Med 2000; 35: 297–9PubMed Kennedy RM, McAllister JD. Midazolam with ketamine: who benefits? Ann Emerg Med 2000; 35: 297–9PubMed
129.
Zurück zum Zitat Carson IW, Moore J, Balmer JP, et al. Laryngeal competence with ketamine and other drugs. Anesthesiology 1973; 38: 128–33PubMed Carson IW, Moore J, Balmer JP, et al. Laryngeal competence with ketamine and other drugs. Anesthesiology 1973; 38: 128–33PubMed
130.
Zurück zum Zitat Mitchell RK, Koury SI, Stone CK. Respiratory arrest after intramuscular ketamine in a 2-year-old child. Am J Emerg Med 1996; 14: 580–1PubMed Mitchell RK, Koury SI, Stone CK. Respiratory arrest after intramuscular ketamine in a 2-year-old child. Am J Emerg Med 1996; 14: 580–1PubMed
131.
Zurück zum Zitat Taylor PA, Towey RM. Depression of laryngeal reflexes during ketamine anaesthesia. BMJ 1971; II: 688–9 Taylor PA, Towey RM. Depression of laryngeal reflexes during ketamine anaesthesia. BMJ 1971; II: 688–9
132.
Zurück zum Zitat Havel CJ, Strait RT, Hennes H. A clinical trial of propofol vs midazolam for procedural sedation in a pediatric emergency department. Acad Emerg Med 1999; 6: 989–97PubMed Havel CJ, Strait RT, Hennes H. A clinical trial of propofol vs midazolam for procedural sedation in a pediatric emergency department. Acad Emerg Med 1999; 6: 989–97PubMed
133.
Zurück zum Zitat Seikel K, Smith K. The safety and efficacy of propofol for procedures and imaging in the pediatric emergency department [abstract]. Pediatrics 1999; 104 Suppl.: 691 Seikel K, Smith K. The safety and efficacy of propofol for procedures and imaging in the pediatric emergency department [abstract]. Pediatrics 1999; 104 Suppl.: 691
134.
Zurück zum Zitat Green SM. Propofol for emergency department procedural sedation: not yet ready for prime time. Acad Emerg Med 1999; 6: 975–8PubMed Green SM. Propofol for emergency department procedural sedation: not yet ready for prime time. Acad Emerg Med 1999; 6: 975–8PubMed
135.
Zurück zum Zitat Kohrs R, Durieux M. Ketamine: teaching an old dog new tricks. Anesth Analg 1998; 87: 1186–93PubMed Kohrs R, Durieux M. Ketamine: teaching an old dog new tricks. Anesth Analg 1998; 87: 1186–93PubMed
Metadaten
Titel
Pharmacological Management of Pain and Anxiety During Emergency Procedures in Children
verfasst von
Dr Robert M. Kennedy
Jan D. Luhmann
Publikationsdatum
01.05.2001
Verlag
Springer International Publishing
Erschienen in
Pediatric Drugs / Ausgabe 5/2001
Print ISSN: 1174-5878
Elektronische ISSN: 1179-2019
DOI
https://doi.org/10.2165/00128072-200103050-00003

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