Introduction
Methods and materials
Eligibility criteria
Baseline evaluation
Intensity modulated radiation therapy (IMRT)
Concurrent chemotherapy
Chemotherapy and surgery
Evaluation of tumor response
Evaluation of toxicity
Study design and endpoints
Results
Demographic and clinical features
No. | % | |
---|---|---|
Gender | ||
Male | 28 | 87.5 |
Female | 4 | 12.5 |
Age | ||
Median | 58.5 | |
Range | 35-75 | |
Distance from anal verge | ||
Median | 5 | |
Range | 3-10 | |
Initial T stage | ||
T3 | 19 | 59.4 |
T4 | 13 | 40.6 |
Initial N stage | ||
N1 | 3 | 9.4 |
N2 | 29 | 90.6 |
Initial M stage | ||
M1a | 20 | 62.5 |
M1b | 12 | 37.5 |
Distant metastases organs | ||
liver alone | 16 | 50.0 |
lung alone | 3 | 9.4 |
bone alone | 1 | 3.1 |
liver and lung | 10 | 31.3 |
liver and intra-abdominal | 2 | 6.3 |
Total metastasis number | ||
1 | 1 | 3.1 |
2 | 2 | 6.3 |
3 | 3 | 9.4 |
>3 | 26 | 81.3 |
Total | 32 |
Combined chemoradiotherapy
Grade 1 | Grade 2 | Grade 3 | ||||
---|---|---|---|---|---|---|
n | % | n | % | n | % | |
Diarrhea | 11 | 34.4 | 5 | 15.6 | 5 | 15.6 |
Hematologic | 6 | 18.8 | 3 | 9.4 | 2 | 6.3 |
Fatigue | 4 | 12.5 | 4 | 12.5 | 2 | 6.3 |
Radiation dermatitis | 9 | 28.1 | 9 | 28.1 | 6 | 18.8 |
Neurosensory | 1 | 3.1 | 1 | 3.1 | 0 | 0.0 |
Hand-foot syndrome | 0 | 0 | 1 | 3.1 | 0 | 0.0 |
Tumor response to CRT
Surgery
No. | % | |
---|---|---|
YpT stage | ||
T0 | 5 | 35.7 |
T2 | 1 | 7.1 |
T3 | 7 | 50.0 |
T4 | 1 | 7.1 |
YpN stage | ||
N0 | 10 | 71.4 |
N1 | 3 | 21.4 |
N2 | 1 | 7.1 |
Downstaging | ||
Yes | 12 | 85.7 |
No | 2 | 14.3 |
Total | 14 |
Follow up
Further analysis of the 9 patients who received definitive therapy
Definitive group | Non-definitive group | P value | |
---|---|---|---|
(Num) | (Num) | ||
Gender | |||
Male | 7 | 21 | |
Female | 2 | 2 | 0.557* |
Age | |||
Median | 57 | 59 | |
Range | 41-65 | 35-76 | 0.765$ |
Distance from anal verge | |||
Median | 5 | 5 | |
Range | 3-8 | 3-10 | 0.649$ |
Initial T stage | |||
T3 | 6 | 13 | |
T4 | 3 | 10 | 0.238# |
Initial N stage | |||
N1 | 0 | 3 | |
N2 | 9 | 20 | 0.541* |
Initial metastases number | |||
<=3 | 2 | 1 | |
>3 | 7 | 22 | 0.184* |
Total | 9 | 23 |