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02.01.2021 | Original Article

Photobiomodulation and diffusing optical fiber on spinal cord’s impact on nerve cells from normal spinal cord tissue in piglets

verfasst von: Xiaoshuang Zuo, Zhuowen Liang, Jiawei Zhang, Shuang Wang, Qiao Zheng, Yangguang Ma, Penghui Li, Tan Ding, Xueyu Hu, Zhe Wang

Erschienen in: Lasers in Medical Science | Ausgabe 1/2022

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Abstract

Experts have proven that photobiological regulation therapy for spinal cord injury promotes the spinal repair following injury. The traditional irradiation therapy mode is indirect (percutaneous irradiation), which could significantly lower the effective use of light energy. In earlier studies, we developed an implantable optical fiber that one can embed above the spinal cord lamina, and the light directly is cast onto the surface of the spinal cord in a way that can dramatically improve energy use. Nonetheless, it remains to be seen whether near-infrared light diffused by embedded optical fiber can have side effects on the surrounding nerve cells. Given this, we implanted optical fiber on the lamina of a normal spinal cord to observe the structural integrity of the tissue using morphological staining; we also used immunohistochemistry to detect inflammatory factors. Considering the existing studies, we meant to determine that the light energy diffused by embedded optical fiber has no side effect on the normal tissue. The results of this study will lay a foundation for the clinical application of the treatment of spinal cord injury by near-infrared light irradiation.

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Titel: Photobiomodulation and diffusing optical fiber on spinal cord’s impact on nerve cells from normal spinal cord tissue in piglets
verfasst von: Xiaoshuang Zuo
Zhuowen Liang
Jiawei Zhang
Shuang Wang
Qiao Zheng
Yangguang Ma
Penghui Li
Tan Ding
Xueyu Hu
Zhe Wang
Publikationsdatum: 02.01.2021
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2022
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-020-03231-8

Springer Medizin

Abstract

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