nach oben

Lasers in Medical Science

Erschienen in:

13.01.2021 | Original Article

Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions

verfasst von: Bo Wang, Ying Huang

Erschienen in: Lasers in Medical Science | Ausgabe 1/2022

Einloggen, um Zugang zu erhalten

Abstract

Immunotherapy of tumors has become a research hotspot. Tumor-associated macrophages (TAMs) are the most abundant interstitial cells in a tumor’s microenvironment. As the concentration of the prepared nanoparticles increased, so their cytotoxicity of intensified. Under photothermal conditions, mAb-CD163/Au inhibited tumor invasion by killing M2 macrophages in vitro. After exposure to near-infrared (NIR) laser, mAb-CD163/Au inhibited tumor growth in vivo. The gold nanoparticles were modified to target M2 macrophages. Under NIR laser irradiation, mAb-CD163/Au achieved antitumor effects by killing M2 macrophages in vitro and in vivo.

Junttila MR, de Sauvage FJ (2013) Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501(7467):346–354. https://doi.org/10.1038/nature12626CrossRefPubMed

Frankel T, Lanfranca MP, Zou W (2017) The role of tumor microenvironment in cancer immunotherapy. Adv Exp Med Biol 1036:51–64. https://doi.org/10.1007/978-3-319-67577-0_4CrossRefPubMed

Rhee I (2016) Diverse macrophages polarization in tumor microenvironment. Arch Pharm Res 39(11):1588–1596. https://doi.org/10.1007/s12272-016-0820-yCrossRefPubMed

Shapouri-Moghaddam A, Mohammadian S, Vazini H, Taghadosi M, Esmaeili SA, Mardani F, Seifi B, Mohammadi A, Afshari JT, Sahebkar A (2018) Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol 233(9):6425–6440. https://doi.org/10.1002/jcp.26429CrossRefPubMed

Chen Y, Song Y, Du W, Gong L, Chang H, Zou Z (2019) Tumor-associated macrophages: an accomplice in solid tumor progression. J Biomed Sci 26(1):78. https://doi.org/10.1186/s12929-019-0568-zCrossRefPubMedPubMedCentral

Mantovani A, Marchesi F, Malesci A, Laghi L, Allavena P (2017) Tumour-associated macrophages as treatment targets in oncology. Nat Rev Clin Oncol 14(7):399–416. https://doi.org/10.1038/nrclinonc.2016.217CrossRefPubMedPubMedCentral

Locy H, de Mey S, de Mey W, De Ridder M, Thielemans K, Maenhout SK (2018) Immunomodulation of the tumor microenvironment: turn foe into friend. Front Immunol 9:2909. https://doi.org/10.3389/fimmu.2018.02909CrossRefPubMedPubMedCentral

Dougan M, Dougan SK (2017) Targeting immunotherapy to the tumor microenvironment. J Cell Biochem 118(10):3049–3054. https://doi.org/10.1002/jcb.26005CrossRefPubMed

Andón FT, Digifico E, Maeda A, Erreni M, Mantovani A, Alonso MJ, Allavena P (2017) Targeting tumor associated macrophages: the new challenge for nanomedicine. Semin Immunol 34:103–113. https://doi.org/10.1016/j.smim.2017.09.004CrossRefPubMed

10.

Ye J, Yang Y, Dong W, Gao Y, Meng Y, Wang H, Li L, Jin J, Ji M, Xia X, Chen X, Jin Y, Liu Y (2019) Drug-free mannosylated liposomes inhibit tumor growth by promoting the polarization of tumor-associated macrophages. Int J Nanomedicine 14:3203–3220. https://doi.org/10.2147/ijn.s207589CrossRefPubMedPubMedCentral

11.

Onofre G, Kolácková M, Jankovicová K, Krejsek J (2009) Scavenger receptor CD163 and its biological functions. Acta Med (Hradec Kralove) 52(2):57–61CrossRef

12.

Etzerodt A, Moestrup SK (2013) CD163 and inflammation: biological, diagnostic, and therapeutic aspects. Antioxid Redox Signal 18(17):2352–2363. https://doi.org/10.1089/ars.2012.4834CrossRefPubMedPubMedCentral

13.

Barros MH, Hauck F, Dreyer JH, Kempkes B, Niedobitek G (2013) Macrophage polarisation: an immunohistochemical approach for identifying M1 and M2 macrophages. PLoS One 8(11):e80908. https://doi.org/10.1371/journal.pone.0080908CrossRefPubMedPubMedCentral

14.

Almeida JP, Chen AL, Foster A, Drezek R (2011) In vivo biodistribution of nanoparticles. Nanomedicine (London, England) 6(5):815–835. https://doi.org/10.2217/nnm.11.79CrossRef

15.

Boisselier E, Astruc D (2009) Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev 38(6):1759–1782. https://doi.org/10.1039/b806051gCrossRefPubMed

16.

Singh P, Pandit S, Mokkapati V, Garg A, Ravikumar V, Mijakovic I (2018) Gold nanoparticles in diagnostics and therapeutics for human cancer. Int J Mol Sci 19(7). https://doi.org/10.3390/ijms19071979

17.

Colombe C, Le Guevel X, Martin-Serrano A, Henry M, Porret E, Comby-Zerbino C, Antoine R, Atallah I, Busser B, Coll JL, Righini CA, Sancey L (2019) Gold nanoclusters as a contrast agent for image-guided surgery of head and neck tumors. Nanomed Nanotechnol Biol Med. https://doi.org/10.1016/j.nano.2019.04.014

18.

Ali MRK, Wu Y, Tang Y, Xiao H, Chen K, Han T, Fang N, Wu R, El-Sayed MA (2017) Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins. Proc Natl Acad Sci U S A 114(28):E5655–e5663. https://doi.org/10.1073/pnas.1703151114CrossRefPubMedPubMedCentral

19.

Encinas-Basurto D, Ibarra J, Juarez J, Pardo A, Barbosa S, Taboada P, Valdez MA (2018) Hybrid folic acid-conjugated gold nanorods-loaded human serum albumin nanoparticles for simultaneous photothermal and chemotherapeutic therapy. Mater Sci Eng C Mater Biol Appl 91:669–678. https://doi.org/10.1016/j.msec.2018.06.002CrossRefPubMed

20.

Adena SKR, Upadhyay M, Vardhan H, Mishra B (2018) Development, optimization, and in vitro characterization of dasatinib-loaded PEG functionalized chitosan capped gold nanoparticles using Box-Behnken experimental design. Drug Dev Ind Pharm 44(3):493–501. https://doi.org/10.1080/03639045.2017.1402919CrossRefPubMed

21.

Kalimuthu K, Lubin BC, Bazylevich A, Gellerman G, Shpilberg O, Luboshits G, Firer MA (2018) Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells. Journal of nanobiotechnology 16(1):34. https://doi.org/10.1186/s12951-018-0362-1CrossRefPubMedPubMedCentral

22.

Ramezani F (2019) Effects of orientation on the stability and affinity of antibody-GNP conjugation. Protein J 38(2):134–141. https://doi.org/10.1007/s10930-019-09812-zCrossRefPubMed

23.

Liu Y, Ma W, Wang J (2018) Theranostics of gold nanoparticles with an emphasis on photoacoustic imaging and photothermal therapy. Curr Pharm Des 24(23):2719–2728. https://doi.org/10.2174/1381612824666180604112201CrossRefPubMed

24.

Cai H, Shen T, Kirillov AM, Zhang Y, Shan C, Li X, Liu W, Tang Y (2017) Self-assembled upconversion nanoparticle clusters for NIR-controlled drug release and synergistic therapy after conjugation with gold nanoparticles. Inorg Chem 56(9):5295–5304. https://doi.org/10.1021/acs.inorgchem.7b00380CrossRefPubMed

25.

Lazarides AL, Whitley MJ, Strasfeld DB, Cardona DM, Ferrer JM, Mueller JL, Fu HL, Bartholf DeWitt S, Brigman BE, Ramanujam N, Kirsch DG, Eward WC (2016) A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma. Theranostics 6(2):155–166. https://doi.org/10.7150/thno.13536CrossRefPubMedPubMedCentral

26.

Fan Y, Sun Y, Chang W, Zhang X, Tang J, Zhang L, Liao H (2018) Bioluminescence imaging and two-photon microscopy guided laser ablation of GBM decreases tumor burden. Theranostics 8(15):4072–4085. https://doi.org/10.7150/thno.25357CrossRefPubMedPubMedCentral

27.

Fan Y, Zhang B, Chang W, Zhang X, Liao H (2018) A novel integration of spectral-domain optical-coherence-tomography and laser-ablation system for precision treatment. Int J Comput Assist Radiol Surg 13(3):411–423. https://doi.org/10.1007/s11548-017-1664-8CrossRefPubMed

28.

Gallo J, García I, Genicio N, Padro D, Penadés S (2011) Specific labelling of cell populations in blood with targeted immuno-fluorescent/magnetic glyconanoparticles. Biomaterials 32(36):9818–9825. https://doi.org/10.1016/j.biomaterials.2011.09.010CrossRefPubMed

29.

Tarin C, Carril M, Martin-Ventura JL, Markuerkiaga I, Padro D, Llamas-Granda P, Moreno JA, García I, Genicio N, Plaza-Garcia S, Blanco-Colio LM, Penades S, Egido J (2015) Targeted gold-coated iron oxide nanoparticles for CD163 detection in atherosclerosis by MRI. Sci Rep 5:17135. https://doi.org/10.1038/srep17135CrossRefPubMedPubMedCentral

30.

Genin M, Clement F, Fattaccioli A, Raes M, Michiels C (2015) M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide. BMC Cancer 15:577–577. https://doi.org/10.1186/s12885-015-1546-9CrossRefPubMedPubMedCentral

31.

Zhang Y, He J, Wang Y, Wen J, Zou Y, Yang Z, He X (2018) Photothermal therapy with AuNRs and EGFRmAb-AuNRs inhibits subcutaneous transplantable hypopharyngeal tumors in nude mice. Int J Oncol 53(6):2647–2658. https://doi.org/10.3892/ijo.2018.4559CrossRefPubMed

32.

Dickerson EB, Dreaden EC, Huang X, El-Sayed IH, Chu H, Pushpanketh S, McDonald JF, El-Sayed MA (2008) Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. Cancer Lett 269(1):57–66. https://doi.org/10.1016/j.canlet.2008.04.026CrossRefPubMedPubMedCentral

33.

Huang X, El-Sayed IH, Qian W, El-Sayed MA (2006) Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J Am Chem Soc 128(6):2115–2120. https://doi.org/10.1021/ja057254aCrossRefPubMed

34.

Liu Y, Crawford BM, Vo-Dinh T (2018) Gold nanoparticles-mediated photothermal therapy and immunotherapy. Immunotherapy 10(13):1175–1188. https://doi.org/10.2217/imt-2018-0029CrossRefPubMed

35.

Martinez FO, Gordon S, Locati M, Mantovani A (2006) Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. Journal of immunology (Baltimore, Md : 1950) 177(10):7303–7311. https://doi.org/10.4049/jimmunol.177.10.7303CrossRef

36.

Hirose K, Iwabuchi K, Shimada K, Kiyanagi T, Iwahara C, Nakayama H, Daida H (2011) Different responses to oxidized low-density lipoproteins in human polarized macrophages. Lipids Health Dis 10:1. https://doi.org/10.1186/1476-511x-10-1CrossRefPubMedPubMedCentral

37.

Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL (2013) A regenerative approach to the treatment of multiple sclerosis. Nature 502(7471):327–332. https://doi.org/10.1038/nature12647CrossRefPubMedPubMedCentral

38.

Park JH, von Maltzahn G, Zhang L, Schwartz MP, Ruoslahti E, Bhatia SN, Sailor MJ (2008) Magnetic iron oxide nanoworms for tumor targeting and imaging. Advanced materials (Deerfield Beach, Fla) 20(9):1630–1635. https://doi.org/10.1002/adma.200800004CrossRef

Titel: Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions
verfasst von: Bo Wang
Ying Huang
Publikationsdatum: 13.01.2021
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2022
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03248-7

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2022

Photobiomodulation exerts anti-inflammatory effects on the vascular and cellular phases of experimental inflammatory models

Photobiomodulation and Sida tuberculata combination declines the inflammation’s markers in knee-induced osteoarthritis

Efficacy and safety of non-thermal nitrogen plasma versus long-pulsed Nd:YAG laser for hand rejuvenation

Erbium lasers in non-surgical periodontal therapy: an umbrella review and evidence gap map analysis

Photobiomodulation using LLLT and LED of cells involved in osseointegration and peri-implant soft tissue healing

Hemorrhoid laser procedure (HeLP) for second- and third-degree hemorrhoids: results from a long-term follow-up analysis