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Lasers in Medical Science

Erschienen in:

26.05.2020 | Original Article

Photobiomodulation with 808-nm diode laser enhances gingival wound healing by promoting migration of human gingival mesenchymal stem cells via ROS/JNK/NF-κB/MMP-1 pathway

verfasst von: Jie Feng, Xiaoyan Li, Siying Zhu, Yongmei Xie, Juan Du, Huabing Ge, Yuxing Bai, Yi Liu, Lijia Guo

Erschienen in: Lasers in Medical Science | Ausgabe 8/2020

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Abstract

Photobiomodulation (PBM) has been shown to improve wound healing by promoting mesenchymal stem cell migration and proliferation. However, it remains unknown whether an 808-nm diode laser can influence human gingival mesenchymal stem cells (HGMSCs), and which dose this works well. In the present study, it was found that PBM could promote the migration of HGMSCs but not the proliferation. Furthermore, PBM could activate mitochondrial ROS, which could elevate the phosphorylation levels of JNK and IKB in HGMSCs, and further activate NF-κB as the nuclear translocation of p65 is elevated. Taken together, these present results indicate that PBM might promote cell migration via the ROS/JNK/NF-κB pathway.

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Titel: Photobiomodulation with 808-nm diode laser enhances gingival wound healing by promoting migration of human gingival mesenchymal stem cells via ROS/JNK/NF-κB/MMP-1 pathway
verfasst von: Jie Feng
Xiaoyan Li
Siying Zhu
Yongmei Xie
Juan Du
Huabing Ge
Yuxing Bai
Yi Liu
Lijia Guo
Publikationsdatum: 26.05.2020
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 8/2020
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-020-03040-z

Springer Medizin

Abstract

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