Erschienen in:
01.05.2015 | Editorial Commentary
Pituitary Size and Response of Growth Hormone Deficient Children to Growth Hormone Therapy
verfasst von:
P. S. N. Menon
Erschienen in:
Indian Journal of Pediatrics
|
Ausgabe 5/2015
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Excerpt
Significant strides have been made on growth hormone (GH) therapy in children and adolescents over the past five decades. The launch of recombinant human GH (rHGH) in 1985 eliminated the risk of Creutzfeldt-Jakob disease with cadaveric GH; ensured an ongoing unlimited supply and also increased the number of children eligible for therapy. The indications for rHGH therapy were expanded to include many chronic non-endocrine diseases associated with significant short stature. Despite mounting evidence of efficacy and safety of GH in various growth disorders, the cost of therapy remains the major constraint in developing countries. …