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Acta Diabetologica

Erschienen in:

08.09.2016 | Original Article

Plasma phospholipid fatty acid composition and desaturase activity in women with gestational diabetes mellitus before and after delivery

verfasst von: S. Burlina, M. G. Dalfrà, A. Barison, R. Marin, E. Ragazzi, G. Sartore, A. Lapolla

Erschienen in: Acta Diabetologica | Ausgabe 1/2017

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Abstract

Aims

Analyze plasma phospholipid fatty acids (PPFA) composition and desaturase activity in women with gestational diabetes (GDM) and in women with a normal glucose tolerance (NGT) before and after delivery, and to evaluate the possible relationship between desaturase activity and inflammatory parameters.

Methods

PPFA composition was analyzed by gas chromatography in 21 women with GDM and from 21 with NGT, during the third trimester of pregnancy and 6 months after delivery. We used fatty acid product-to-precursor ratios to estimate desaturase activity, and we also measured in all women interleukins six and ten, tumor necrosis factor alpha and C-reactive protein.

Results

No significant differences were observed between NGT and GDM women in terms of PPFA composition, both in pregnancy and after pregnancy. Estimated desaturase Δ9-18 activity was significantly higher, and estimated desaturase Δ5 activity was significantly lower during pregnancy in all women. We observed no correlations between inflammatory markers and desaturases activity, during or after pregnancy, in both groups.

Conclusions

Our data suggest that GDM does not influence PPFA composition and desaturase activity during pregnancy. In addition, late pregnancy characterized by hyperinsulinemia appears to upregulate desaturase Δ9-18 activity in NGT and GDM women.

Sattar N, Greer IA, Louden J et al (1997) Lipoprotein subfraction changes in normal pregnancy: threshold effect of plasma triglyceride on appearance of small dense low density lipoprotein. J Clin Endocrinol Metab 82:2483–2491PubMed

Al MD, van Houwelingen AC, Kester AD, Hasaart TH, de Jong AE, Hornstra G (1995) Maternal essential fatty acid patterns during normal pregnancy and their relationship to the neonatal essential fatty acid status. Br J Nutr 74:55–68CrossRefPubMed

Sanjurjo P, Matorras R, Ingunza N et al (1993) Cross-sectional study of percentual changes in total plasmatic fatty acids during pregnancy. Horm Metab Res 25:590–592CrossRefPubMed

Reaven GM, Banting lecture (1988) Role of insulin resistance in human disease. Diabetes 37:1595–1607CrossRefPubMed

Kendall DM, Harmel AP (2002) The metabolic syndrome, type 2 diabetes, and cardiovascular disease: understanding the role of insulin resistance. Am J Manag Care 8:S635–S653PubMed

Thomas BA, Ghebremeskel K, Lowy C, Offley-Shore B, Crawford MA (2005) Plasma fatty acids of neonates born to mothers with and without gestational diabetes. Prostaglandins Leukot Essent Fat Acids 72:335–341CrossRef

Wijendran V, Bendel RB, Couch SC, Philipson EH, Cheruku S, Lammi-Keefe CJ (2000) Fetal erythrocyte phospholipid polyunsaturated fatty acids are altered in pregnancy complicated with gestational diabetes mellitus. Lipids 35:927–931CrossRefPubMed

Ghebremeskel K, Thomas B, Lowy C, Min Y, Crawford MA (2004) Type 1 diabetes compromises plasma arachidonic and docosahexaenoic acids in newborn babies. Lipids 39:335–342CrossRefPubMed

Konard RJ, Stoller JZ, Gao ZY, Wolf BA (1996) Eicosapentaenoic acid (C20:5) augments glucose-induced insulin secretion from beta-TC3 insulinoma cells. Pancreas 13:253–258CrossRefPubMed

10.

Dixon G, Nolan J, McClenaghan NH, Flatt PR, Newsholme P (2004) Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity. Clin Sci (Lond) 106:191–199CrossRef

11.

Min Y, Lowy C, Ghebremeskel K, Thomas B, Bitsanis D, Crawford MA (2005) Fetal erythrocyte membrane lipids modification: preliminary observation of an early sign of compromised insulin sensitivity in offspring of gestational diabetic women. Diabet Med 22:914–920CrossRefPubMed

12.

Zhao JP, Levy E, Fraser WD et al (2014) Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. PLoS One 9:e85054CrossRefPubMedPubMedCentral

13.

Vessby B, Gustaffsson IB, Tengblad S, Boberg M, Andersson A (2002) Desaturation and elongation of fatty acids and insulin action. Ann N Y Acad Sci 967:183–195CrossRefPubMed

14.

Arisaka M, Arisaka O, Yamashiro Y (1991) Fatty acid and prostaglandin metabolism in children with diabetes mellitus. II. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. Prostaglandins Leukot Essent Fat Acids 43:197–201CrossRef

15.

Brenner RR, Bernasconi AM, Garda HA (2000) Effect of experimental diabetes on the fatty acid composition, molecular species of phosphatidyl-choline and physical properties of hepatic microsomal membranes. Prostaglandins Leukot Essent Fat Acids 63:167–176CrossRef

16.

Hadden DR, McLaughlin C (2009) Normal and abnormal maternal metabolism during pregnancy. Semin Fetal Neonatal Med 14:66–71CrossRefPubMed

17.

Carpenter MW, Coustan DR (1982) Criteria for screening tests for gestational diabetes. Am J Obstet Gynecol 144:768–773CrossRefPubMed

18.

Kitzmiller JL, Block JM, Brown FM et al (2008) Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for care. Diabetes Care 31:1060–1079CrossRefPubMedPubMedCentral

19.

Huggett AST, Nixon DA (1957) Use of glucose oxidase peroxidase and O-dianisidine in the determination of blood and urine glucose. Lancet 2:368–370CrossRef

20.

Mosca A, Lapolla A, Gillery P (2013) Glycemic control in the clinical management of diabetic patients. Clin Chem Lab Med 51:753–766PubMed

21.

Hainline A, Karon J, Lippel K (1982) Lipid research clinics program. Manual of laboratory operations, lipid and lipoprotein analysis, 2nd edn. National Heart, Lung, and Blood Institute Bethesda, U. S. Government Printing Office, Maryland

22.

Fossati P, Prencipe L (1982) Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem 28:2077e80

23.

Folch J, Lees M, Stanley GHS (1957) A single method for the isolation and purification of total lipids from animal tissue. J Biol Chem 226:497–507PubMed

24.

Egberts J, Bulskool R (1988) Isolation of the acidic phospholipid phosphatidylglycerol from pulmonary surfactant by sorbent extraction chromatography. Clin Chem 34:163–164PubMed

25.

Morrison WR, Smith LM (1964) Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J Lipid Res 5:600–608PubMed

26.

Vessby B, Gustaffsson IB, Tengblad S, Boberg M, Andersson A (2002) Desaturation and elongation of fatty acids and insulin action. Ann N Y Acad Sci 967:183–195CrossRefPubMed

27.

Nakamura MT, Nara TY (2004) Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 24:345–376CrossRefPubMed

28.

Toeller M, Klischan A, Heitkamp G et al (1996) Nutritional intake of 2868 IDDM patients from 30 centres in Europe. Eurodiab IDDM complications study group. Diabetologia 39:929–939CrossRefPubMed

29.

Massiera F, Saint-Marc P, Seydoux J et al (2003) Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res 44:271–279CrossRefPubMed

30.

Reyes H (1992) The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy. Gastroenterol Clin North Am 21:905–921PubMed

31.

Robberecht E, Koletzko B, Christophe AB (1997) Several mechanisms contribute to the abnormal fatty acid composition of serum phospholipids and cholesterol esters in cholestatic children with extrahepatic biliary atresia. Prostaglandins Leukot Essent Fat Acids 56:199–204CrossRef

32.

Warensjo E, Rosell M, Hellenius ML, Vessby B, De Faire U, Riserus U (2009) Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance. Lipids Heal Dis 8:37CrossRef

33.

Okada T, Furuhashi N, Kuromori Y, Miyashita M, Iwata F, Harada K (2005) Plasma palmitoleic acid content and obesity in children. Am J Clin Nutr 82:747–750PubMed

34.

Prasad MR, Joshi VC (1979) Regulation of rat hepatic stearoyl coenzyme A desaturase. The roles of insulin and carbohydrate. J Biol Chem 25:997–999

35.

Kuipers RS, Luxwolda MF, Sango WS et al (2011) Postpartum changes in maternal and infant erythrocyte fatty acids are likely to be driven by restoring insulin sensitivity and DHA status. Med Hypotheses 76:794–801CrossRefPubMed

36.

Paton CM, Ntambi JM (2009) Biochemical and physiological function of stearoyl-CoA desaturase. Am J Physiol Endocrinol Metab 297:E28–E37CrossRefPubMed

37.

Gutiérrez-Juárez R, Pocai A, Mulas C et al (2006) Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J Clin Investig 116:1686–1695CrossRefPubMedPubMedCentral

38.

Sartore G, Lapolla A, Reitano R et al (2008) Desaturase activities and metabolic control in type 2 diabetes. Prostaglandins Leukot Essent Fat Acids 79:55–58CrossRef

39.

Xu J, Zhao YH, Chen YP et al (2014) Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and meta-analysis. Sci World J 2014:926932

40.

Sampath H, Ntambi JM (2014) Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance. J Biol Chem 289:2482–2488CrossRefPubMed

Titel: Plasma phospholipid fatty acid composition and desaturase activity in women with gestational diabetes mellitus before and after delivery
verfasst von: S. Burlina
M. G. Dalfrà
A. Barison
R. Marin
E. Ragazzi
G. Sartore
A. Lapolla
Publikationsdatum: 08.09.2016
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 1/2017
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-016-0901-x

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Plasma phospholipid fatty acid composition and desaturase activity in women with gestational diabetes mellitus before and after delivery

Abstract

Aims

Methods

Results

Conclusions

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