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Advances in Gerontology

Erschienen in:

01.07.2020

Plasmalogens in the Pathophysiology and Therapy of Age-Specific Diseases

verfasst von: O. Yu. Kytikova, T. P. Novgorodtseva, M. V. Antonyuk, T. A. Gvozdenko

Erschienen in: Advances in Gerontology | Ausgabe 3/2020

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Abstract

The pathogenesis of age-related diseases such as metabolic syndrome, type-2 diabetes, Parkinson’s disease, and Alzheimer’s disease is associated with oxidative stress and chronic inflammation. Impairment of redox homeostasis is accompanied by the development of peroxisome dysfunction and impaired biosynthesis of plasmalogens, which may be associated with aging and the development of age-dependent pathology. Plasmalogens, which reflect the functional activity of peroxisomes, can serve not only as potential biomarkers of diseases associated with oxidative stress and aging but also as an important therapeutic target. The purpose of this review was to analyze the current knowledge of understudied biological and pathological aspects of plasmalogen participation in the pathophysiology of neurodegenerative and metabolic diseases of older persons. An understanding of the role of plasmalogens in the pathophysiology of these diseases can lead to the development of effective diagnostic and prognostic biomarkers, as well as treatment methods for neurodegenerative and metabolic diseases of older people.

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Titel: Plasmalogens in the Pathophysiology and Therapy of Age-Specific Diseases
verfasst von: O. Yu. Kytikova
T. P. Novgorodtseva
M. V. Antonyuk
T. A. Gvozdenko
Publikationsdatum: 01.07.2020
Verlag: Pleiades Publishing
Erschienen in: Advances in Gerontology / Ausgabe 3/2020
Print ISSN: 2079-0570
Elektronische ISSN: 2079-0589
DOI: https://doi.org/10.1134/S207905702003011X

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