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Clinical Oral Investigations

Erschienen in:

28.06.2021 | Review

Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies

verfasst von: Diana G. Soares, Ester A. F. Bordini, W. Benton Swanson, Carlos A. de Souza Costa, Marco C. Bottino

Erschienen in: Clinical Oral Investigations | Ausgabe 8/2021

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Abstract

Objectives

The aim of this review is to highlight recent progress in the field of biomaterials-mediated dental pulp tissue engineering. Specifically, we aim to underscore the critical design criteria of biomaterial platforms that are advantageous for pulp tissue engineering, discuss models for preclinical evaluation, and present new and innovative multifunctional strategies that hold promise for clinical translation.

Materials and methods

The current article is a comprehensive overview of recent progress over the last 5 years. In detail, we surveyed the literature in regenerative pulp biology, including novel biologic and biomaterials approaches, and those that combined multiple strategies, towards more clinically relevant models. PubMed searches were performed using the keywords: “regenerative dentistry,” “dental pulp regeneration,” “regenerative endodontics,” and “dental pulp therapy.”

Results

Significant contributions to the field of regenerative dentistry have been made in the last 5 years, as evidenced by a significant body of publications. We chose exemplary studies that we believe are progressive towards clinically translatable solutions. We close this review with an outlook towards the future of pulp regeneration strategies and their clinical translation.

Conclusions

Current clinical treatments lack functional and predictable pulp regeneration and are more focused on the treatment of the consequences of pulp exposure, rather than the restoration of healthy dental pulp.

Clinical relevance

Clinically, there is great demand for bioinspired biomaterial strategies that are safe, efficacious, and easy to use, and clinicians are eager for their clinical translation. In particular, we place emphasis on strategies that combine favorable angiogenesis, mineralization, and functional tissue formation, while limiting immune reaction, risk of microbial infection, and pulp necrosis.

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Titel: Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies
verfasst von: Diana G. Soares
Ester A. F. Bordini
W. Benton Swanson
Carlos A. de Souza Costa
Marco C. Bottino
Publikationsdatum: 28.06.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 8/2021
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-021-04013-4

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Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Neu im Fachgebiet Zahnmedizin

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

Parodontalbehandlung verbessert Prognose bei Katheterablation

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

Zell-Organisatoren unter Druck: Mechanismen des embryonalen Zahnwachstums aufgedeckt

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Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

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Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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