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Journal of General Internal Medicine

Erschienen in:

22.04.2019 | Clinical Practice: Clinical Vignettes

Pneumococcal Bacteremia Complicated by Hemophagocytic Lymphohistiocytosis

verfasst von: Frederick Howard, MD, Christopher Sankey, MD, FACP, SFHM

Erschienen in: Journal of General Internal Medicine | Ausgabe 8/2019

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Abstract

From pneumonia to pericarditis, from sepsis to splenic abscess, Streptococcus pneumoniae is the causative agent of a diverse array of pyogenic disease. With the introduction of vaccines and effective antibiotic treatments, the incidence of complicated streptococcal infection has declined. We report a case of S. pneumoniae bacteremia, in the setting of occult sinusitis, complicated by hemophagocytic lymphohistiocytosis (HLH), disseminated intravascular coagulation (DIC), and recurrent pneumococcal infection. Although severe streptococcal infection has been associated with immunodeficiency or splenectomy, no such predisposition was identified in our patient. We discuss the association of streptococcal infection with HLH and DIC and review occult sinusitis as a source of pneumococcal bacteremia, with the goal of enhancing the “illness scripts” of general medical practitioners to include such entities.

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Titel: Pneumococcal Bacteremia Complicated by Hemophagocytic Lymphohistiocytosis
verfasst von: Frederick Howard, MD
Christopher Sankey, MD, FACP, SFHM
Publikationsdatum: 22.04.2019
Verlag: Springer US
Erschienen in: Journal of General Internal Medicine / Ausgabe 8/2019
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI: https://doi.org/10.1007/s11606-019-05001-x

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