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Journal of Natural Medicines

Erschienen in:

01.01.2019 | Original Paper

Polydatin protects against acute myocardial infarction-induced cardiac damage by activation of Nrf2/HO-1 signaling

verfasst von: Guo Chen, Guorong Liu, Dawei Cao, Mingming Jin, Dongfeng Guo, Xiaoyan Yuan

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2019

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Abstract

Polydatin is a traditional Chinese medicine that provides myocardial protection after acute myocardial infarction (AMI). The study aim was to investigate the myocardial protection polydatin in H9c2 myocardial cells cultured in a hypoxic atmosphere and in a rat AMI model induced by ligating the left anterior descending coronary artery and treated with polydatin 100 mg/kg/day for 30 days. The involvement of Nrf2 in mediating the effects of polydatin was investigated in H9c2 cells following Nrf2 knockdown by transfection of siRNA. Polydatin suppressed hypoxia-induced H9c2 cell apoptosis and reactive oxygen species (ROS) generation by promoting Nrf2/HO-1 signaling. Nrf2 knockdown reversed the protective effects of polydatin against hypoxia-induced myocardial cell injury. The in vivo results were consistent with polydatin suppression of apoptosis and ROS generation in myocardial tissue by promotion of Nrf2/HO-1 signaling. In conclusion, polydatin effectively inhibited hypoxia- and AMI-induced myocardial damage by promotion of Nrf2/HO-1 signaling.

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Titel: Polydatin protects against acute myocardial infarction-induced cardiac damage by activation of Nrf2/HO-1 signaling
verfasst von: Guo Chen
Guorong Liu
Dawei Cao
Mingming Jin
Dongfeng Guo
Xiaoyan Yuan
Publikationsdatum: 01.01.2019
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2019
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1241-7

Springer Medizin

Abstract

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