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Journal of Cancer Research and Clinical Oncology

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01.05.2009 | Original Paper

Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia

verfasst von: W. Pongstaporn, S. Pakakasama, S. Sanguansin, S. Hongeng, Songsak Petmitr

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 5/2009

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Abstract

Purpose

To evaluate the association between glutathione S-transferase Omega (GSTO) genes polymorphism and the susceptibility of acute lymphoblast leukemia (ALL).

Methods

The polymorphism of GSTO1 and GSTO2 genes were analyzed in 99 ALL patients compared with 100 healthy children by PCR-based restriction fragment length polymorphism (RFLP) analysis.

Results

GSTO1*A140D polymorphism was significantly associated with susceptibility to ALL (OR = 2.24, 95% CI = 1.16–4.35, P = 0.009) whereas, GSTO2*N142D genotype was significantly interacted with high risk group of childhood ALL (OR = 5.52, 95% CI = 1.72–17.71, P = 0.004).

Conclusion

This study revealed gene polymorphism in glutathione S-transferase Omega class may be a risk factor to the development of acute childhood lymphoblastic leukemia.

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Titel: Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia
verfasst von: W. Pongstaporn
S. Pakakasama
S. Sanguansin
S. Hongeng
Songsak Petmitr
Publikationsdatum: 01.05.2009
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 5/2009
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-008-0501-4

Springer Medizin

Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia

Abstract

Purpose

Methods

Results

Conclusion

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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