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Current Oral Health Reports

Erschienen in:

11.04.2019 | Microbiology (C Genco, Section Editor)

Poor Oral Health and Its Neurological Consequences: Mechanisms of Porphyromonas gingivalis Involvement in Cognitive Dysfunction

verfasst von: Ingar Olsen, Sim K. Singhrao

Erschienen in: Current Oral Health Reports | Ausgabe 2/2019

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Abstract

Purpose of Review

There is an increasing body of evidence from epidemiology and laboratory investigations demonstrating periodontal disease as a risk factor for dementia. In particular, Porphyromonas gingivalis infections in animal models suggest causal associations with Alzheimer’s disease (AD). This review focuses on how P. gingivalis infections promote the incidence of functional loss in AD.

Recent Findings

The risk of the sporadic form of AD doubles when periodontitis persists for ten or more years. AD differs from other forms of dementia in that the clinical signs together with the presence of amyloid-beta (Aβ) plaques and neurofibrillary tangles must be present at autopsy. P. gingivalis oral infections in mice have demonstrated all of the characteristic pathological and clinical features of AD following infection of the brain.

Summary

Multiple factors (inflammation, Aβ oligomers, and bacterial factors) are likely to disrupt neuronal communication channels (synapses) as a plausible explanation for the functional loss.

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Titel: Poor Oral Health and Its Neurological Consequences: Mechanisms of Porphyromonas gingivalis Involvement in Cognitive Dysfunction
verfasst von: Ingar Olsen
Sim K. Singhrao
Publikationsdatum: 11.04.2019
Verlag: Springer International Publishing
Erschienen in: Current Oral Health Reports / Ausgabe 2/2019
Elektronische ISSN: 2196-3002
DOI: https://doi.org/10.1007/s40496-019-0212-8

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Springer Medizin

Poor Oral Health and Its Neurological Consequences: Mechanisms of Porphyromonas gingivalis Involvement in Cognitive Dysfunction

Abstract

Purpose of Review

Recent Findings

Summary

Neu im Fachgebiet Zahnmedizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

Zell-Organisatoren unter Druck: Mechanismen des embryonalen Zahnwachstums aufgedeckt

Die Oralprophylaxe & Kinderzahnheilkunde umbenannt

Newsletter

Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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