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Osteoporosis International

Erschienen in:

20.08.2018 | Original Article

Post-traumatic stress disorder and incident fractures in the Danish population

verfasst von: T. Jiang, K. Veres, D. Körmendiné Farkas, T. L. Lash, H. T. Sørensen, J. L. Gradus

Erschienen in: Osteoporosis International | Ausgabe 11/2018

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Abstract

Summary

Psychological stress may be associated with increased risk of fractures. It is unknown whether post-traumatic stress disorder (PTSD), a marker of chronic severe psychological stress occurring in response to a traumatic event, influences fracture risk. In this nationwide cohort study, persons with PTSD had an increased risk of fractures compared to the general population.

Introduction

We conducted a population-based national cohort study in Denmark to examine the association between PTSD and incident fractures.

Methods

We examined the incidence rate of overall and specific fractures among patients with clinician-diagnosed PTSD (n = 4114), compared with the incidence rate in the general population from 1995 to 2013, using Danish medical registry data. We further examined differences in associations by gender, age, psychiatric and somatic comorbidity, and follow-up time. We calculated absolute risks, standardized incidence ratios (SIRs), and 95% confidence intervals (95% CIs).

Results

Risk of any fracture among persons with PTSD was 24% (95% CI 20%, 28%) over the study period. The SIR for any fracture was 1.7 (95% CI 1.6, 1.9). We found little evidence of effect measure modification of the association between PTSD and fractures in our stratified analyses.

Conclusions

Our findings suggest that PTSD is associated with increased fracture risk.

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World Health Organization (1993) The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. WHO, Geneva

Pacella ML, Hruska B, Delahanty DL (2013) The physical health consequences of PTSD and PTSD symptoms: a meta-analytic review. J Anxiety Disord 27:33–46. https://doi.org/10.1016/j.janxdis.2012.08.004 CrossRefPubMed

Kessler RC (2000) Posttraumatic stress disorder: the burden to the individual and to society. J Clin Psychiatry 61(Suppl 5):4–12 discussion 13-14PubMed

Pedersen AB, Baggesen LM, Ehrenstein V, Pedersen L, Lasgaard M, Mikkelsen EM (2016) Perceived stress and risk of any osteoporotic fracture. Osteoporos Int 27:2035–2045. https://doi.org/10.1007/s00198-016-3490-1 CrossRefPubMed

Yu H, Watt H, Kesavan C, Johnson PJ, Wergedal JE, Mohan S (2012) Lasting consequences of traumatic events on behavioral and skeletal parameters in a mouse model for post-traumatic stress disorder (PTSD). PLoS One 7:e42684. https://doi.org/10.1371/journal.pone.0042684 CrossRefPubMedPubMedCentral

Möller J, Hallqvist J, Laflamme L, Mattsson F, Ponzer S, Sadigh S, Engström K (2009) Emotional stress as a trigger of falls leading to hip or pelvic fracture. Results from the ToFa study – a case-crossover study among elderly people in Stockholm, Sweden. BMC Geriatr 9:7. https://doi.org/10.1186/1471-2318-9-7 CrossRefPubMedPubMedCentral

Juster R-P, McEwen BS, Lupien SJ (2010) Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev 35:2–16. https://doi.org/10.1016/j.neubiorev.2009.10.002 CrossRefPubMed

Chyun YS, Kream BE, Raisz LG (1984) Cortisol decreases bone formation by inhibiting periosteal cell proliferation. Endocrinology 114:477–480. https://doi.org/10.1210/endo-114-2-477 CrossRefPubMed

Aardal-Eriksson E, Eriksson TE, Thorell LH (2001) Salivary cortisol, posttraumatic stress symptoms, and general health in the acute phase and during 9-month follow-up. Biol Psychiatry 50:986–993. https://doi.org/10.1016/S0006-3223(01)01253-7 CrossRefPubMed

10.

Canalis E (2005) Mechanisms of glucocorticoid action in bone. Curr Osteoporos Rep 3:98–102. https://doi.org/10.1007/s11914-005-0017-7 CrossRefPubMed

11.

van Staa TP, Leufkens HGM, Cooper C (2002) The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporos Int 13:777–787. https://doi.org/10.1007/s001980200108 CrossRefPubMed

12.

Ioannidis G, Pallan S, Papaioannou A, Mulgund M, Rios L, Ma J et al (2014) Glucocorticoids predict 10-year fragility fracture risk in a population-based ambulatory cohort of men and women: Canadian Multicentre Osteoporosis Study (CaMos). Arch Osteoporos 9:169. https://doi.org/10.1007/s11657-013-0169-5 CrossRefPubMedPubMedCentral

13.

Stults-Kolehmainen MA, Sinha R (2014) The effects of stress on physical activity and exercise. Sports Med 44:81–121. https://doi.org/10.1007/s40279-013-0090-5 CrossRefPubMedPubMedCentral

14.

Torres SJ, Nowson CA (2007) Relationship between stress, eating behavior, and obesity. Nutr Burbank Los Angel Cty Calif 23:887–894. https://doi.org/10.1016/j.nut.2007.08.008 CrossRef

15.

Keyes KM, Hatzenbuehler ML, Hasin DS (2011) Stressful life experiences, alcohol consumption, and alcohol use disorders: the epidemiologic evidence for four main types of stressors. Psychopharmacology 218:1–17. https://doi.org/10.1007/s00213-011-2236-1 CrossRefPubMedPubMedCentral

16.

Bray RM, Fairbank JA, Marsden ME (1999) Stress and substance use among military women and men. Am J Drug Alcohol Abuse 25:239–256. https://doi.org/10.1081/ADA-100101858 CrossRefPubMed

17.

Yu H, Watt H, Kesavan C, Mohan S (2013) The negative impact of single prolonged stress (SPS) on bone development in mice. Stress 16:564–570. https://doi.org/10.3109/10253890.2013.806908 CrossRefPubMed

18.

Fink HA, Kuskowski MA, Cauley JA, Taylor BC, Schousboe JT, Cawthon PM et al (2014) Association of stressful life events with accelerated bone loss in older men: the Osteoporotic Fractures in Men (MrOS) Study. Osteoporos Int 25:2833–2839. https://doi.org/10.1007/s00198-014-2853-8 CrossRefPubMedPubMedCentral

19.

Gradus JL, Bozi I, Antonsen S, Svensson E, Lash TL, Resick PA, Hansen JG (2014) Severe stress and adjustment disorder diagnoses in the population of Denmark. J Trauma Stress 27:370–374. https://doi.org/10.1002/jts.21926 CrossRefPubMedPubMedCentral

20.

Schmidt M, Pedersen L, Sørensen HT (2014) The Danish Civil Registration System as a tool in epidemiology. Eur J Epidemiol 29:541–549. https://doi.org/10.1007/s10654-014-9930-3 CrossRefPubMed

21.

Munk-Jørgensen P, Mortensen PB (1997) The Danish Psychiatric Central Register. Dan Med Bull 44:82–84. https://doi.org/10.1177/1403494810395825 CrossRefPubMed

22.

Mors O, Perto GP, Mortensen PB (2011) The Danish Psychiatric Central Research Register. Scand J Public Health 39:54–57. https://doi.org/10.1177/1403494810395825 CrossRefPubMed

23.

Svensson E, Lash TL, Resick PA, Hansen JG, Gradus JL (2015) Validity of reaction to severe stress and adjustment disorder diagnoses in the Danish Psychiatric Central Research Registry. Clin Epidemiol 7:235–242. https://doi.org/10.2147/CLEP.S80514 CrossRefPubMedPubMedCentral

24.

Schmidt M, Schmidt SAJ, Sandegaard JL, Ehrenstein V, Pedersen L, Sørensen HT (2015) The Danish National Patient Registry: a review of content, data quality, and research potential. Clin Epidemiol 7:449–490. https://doi.org/10.2147/CLEP.S91125 CrossRefPubMedPubMedCentral

25.

Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383. https://doi.org/10.1016/0021-9681(87)90171-8 CrossRefPubMed

26.

Rothman K, Boice J, Rothman KJ, Boice JD (1979) Epidemiologic analyses with a programmable calculator. Government Printing Office. n.d, Washington DC

27.

Kanis JA, Johnell O, Oden A, Johansson H, De Laet C, Eisman JA et al (2005) Smoking and fracture risk: a meta-analysis. Osteoporos Int 16:155–162. https://doi.org/10.1007/s00198-004-1640-3 CrossRefPubMed

28.

Koenen KC, Hitsman B, Lyons MJ, Niaura R, McCaffery J, Goldberg J, Eisen SA, True W, Tsuang M (2005) A twin registry study of the relationship between posttraumatic stress disorder and nicotine dependence in men. Arch Gen Psychiatry 62:1258–1265. https://doi.org/10.1001/archpsyc.62.11.1258 CrossRefPubMed

29.

Greenland S, Lash TL (2008) Bias analysis. In: Rothman KJ, Greenland S, Lash TL (eds) Modern epidemiology, 3rd edn. Lippincott, Williams & Wilkins, Philadelphia, pp 345–380

30.

O’Donnell ML, Creamer M, Pattison P (2004) Posttraumatic stress disorder and depression following trauma: understanding comorbidity. Am J Psychiatry 161:1390–1396. https://doi.org/10.1176/appi.ajp.161.8.1390 CrossRefPubMed

31.

Wu Q, Liu J, Gallegos-Orozco JF, Hentz JG (2010) Depression, fracture risk, and bone loss: a meta-analysis of cohort studies. Osteoporos Int 21:1627–1635. https://doi.org/10.1007/s00198-010-1181-x CrossRefPubMed

32.

Lasser K, Boyd JW, Woolhandler S, Himmelstein DU, McCormick D, Bor DH (2000) Smoking and mental illness: a population-based prevalence study. JAMA 284:2606–2610. https://doi.org/10.1001/jama.284.20.2606 CrossRefPubMed

33.

Bohnen N, Nicolson N, Sulon J, Jolles J (1991) Coping style, trait anxiety and cortisol reactivity during mental stress. J Psychosom Res 35:141–147CrossRefPubMed

34.

Sävendahl L (2012) The effect of acute and chronic stress on growth. Sci Signal 5:pt9. https://doi.org/10.1126/scisignal.2003484 CrossRefPubMed

35.

Fu SS, McFall M, Saxon AJ, Beckham JC, Carmody TP, Baker DG, Joseph A (2007) Post-traumatic stress disorder and smoking: a systematic review. Nicotine Tob Res 9:1071–1084. https://doi.org/10.1080/14622200701488418 CrossRefPubMed

36.

Hla MM, Davis JW, Ross PD, Yates AJ, Wasnich RD (2001) The relation between lifestyle factors and biochemical markers of bone turnover among early postmenopausal women. Calcif Tissue Int 68:291–296. https://doi.org/10.1007/BF02390836 CrossRefPubMed

37.

Broulik PD, Jaráb J (1993) The effect of chronic nicotine administration on bone mineral content in mice. Horm Metab Res 25:219–221. https://doi.org/10.1055/s-2007-1002080 CrossRefPubMed

38.

Broulik PD, Rosenkrancová J, Růzicka P, Sedlácek R, Kurcová I (2007) The effect of chronic nicotine administration on bone mineral content and bone strength in normal and castrated male rats. Horm Metab Res 39:20–24. https://doi.org/10.1055/s-2007-957342 CrossRefPubMed

39.

Galatzer-Levy IR, Bryant RA (2013) 636,120 ways to have posttraumatic stress disorder. Perspect Psychol Sci J Assoc Psychol Sci 8:651–662. https://doi.org/10.1177/1745691613504115 CrossRef

Titel: Post-traumatic stress disorder and incident fractures in the Danish population
verfasst von: T. Jiang
K. Veres
D. Körmendiné Farkas
T. L. Lash
H. T. Sørensen
J. L. Gradus
Publikationsdatum: 20.08.2018
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 11/2018
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-018-4644-0

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Summary

Introduction

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