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Erschienen in:

10.06.2020 | Clinical Study

Potential differences between monolingual and bilingual patients in approach and outcome after awake brain surgery

verfasst von: Karim ReFaey, Shashwat Tripathi, Adip G. Bhargav, Sanjeet S. Grewal, Erik H. Middlebrooks, David S. Sabsevitz, Mark Jentoft, Peter Brunner, Adela Wu, William O. Tatum, Anthony Ritaccio, Kaisorn L. Chaichana, Alfredo Quinones-Hinojosa

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2020

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Abstract

Introduction

20.8% of the United States population and 67% of the European population speak two or more languages. Intraoperative different languages, mapping, and localization are crucial. This investigation aims to address three questions between BL and ML patients: (1) Are there differences in complications (i.e. seizures) and DECS techniques during intra-operative brain mapping? (2) Is EOR different? and (3) Are there differences in the recovery pattern post-surgery?

Methods

Data from 56 patients that underwent left-sided awake craniotomy for tumors infiltrating possible dominant hemisphere language areas from September 2016 to June 2019 were identified and analyzed in this study; 14 BL and 42 ML control patients. Patient demographics, education level, and the age of language acquisition were documented and evaluated. fMRI was performed on all participants.

Results

0 (0%) BL and 3 (7%) ML experienced intraoperative seizures (P = 0.73). BL patients received a higher direct DECS current in comparison to the ML patients (average = 4.7, 3.8, respectively, P = 0.03). The extent of resection was higher in ML patients in comparison to the BL patients (80.9 vs. 64.8, respectively, P = 0.04). The post-operative KPS scores were higher in BL patients in comparison to ML patients (84.3, 77.4, respectively, P = 0.03). BL showed lower drop in post-operative KPS in comparison to ML patients (− 4.3, − 8.7, respectively, P = 0.03).

Conclusion

We show that BL patients have a lower incidence of intra-operative seizures, lower EOR, higher post-operative KPS and tolerate higher DECS current, in comparison to ML patients.

Nur mit Berechtigung zugänglich

Bureau USC (2011) Language Use in the United States. https://www2.census.gov/library/publications/2013/acs/acs-22/acs-22.pdf. Accessed Nov 2019

TNS Opinion & Social at the request of Directorate-General Education and Culture D-GfTaD-GfI (2012) Europeans and their Languages. Special Eurobarometer 386, 2019

Kovelman I, Baker SA, Petitto LA (2008) Age of first bilingual language exposure as a new window into bilingual reading development. Bilingualism 11(2):203–223PubMedCrossRef

Lennon P (1990) Investigating fluency in EFL: a quantitative approach. Lang Learn 40(3):387–417. https://doi.org/10.1111/j.1467-1770.1990.tb00669.xCrossRef

De Jong NH (2018) Fluency in second language testing: Insights from different disciplines. Lang Access Q 15(3):237–254

Fillmore CJ, Kempler D, Wang WS (2014) Individual differences in language ability and language behavior. Academic Press, Cambridge

Kovelman I, Baker SA, Petitto LA (2008) Bilingual and monolingual brains compared: a functional magnetic resonance imaging investigation of syntactic processing and a possible "neural signature" of bilingualism. J Cogn Neurosci 20(1):153–169. https://doi.org/10.1162/jocn.2008.20011PubMedPubMedCentralCrossRef

Wattendorf E, Festman J (2008) Images of the multilingual brain: the effect of age of second language acquisition. Annu Rev Appl Linguist 28:3–24CrossRef

Leonard MK, Torres C, Travis KE, Brown TT, Hagler DJ Jr, Dale AM, Elman JL, Halgren E (2011) Language proficiency modulates the recruitment of non-classical language areas in bilinguals. PLoS ONE 6(3):e18240PubMedPubMedCentralCrossRef

10.

Kim KH, Relkin NR, Lee KM, Hirsch J (1997) Distinct cortical areas associated with native and second languages. Nature 388(6638):171–174. https://doi.org/10.1038/40623PubMedCrossRef

11.

Tu L, Wang J, Abutalebi J, Jiang B, Pan X, Li M, Gao W, Yang Y, Liang B, Lu Z, Huang R (2015) Language exposure induced neuroplasticity in the bilingual brain: a follow-up fMRI study. Cortex 64:8–19. https://doi.org/10.1016/j.cortex.2014.09.019PubMedCrossRef

12.

Herbet G, Moritz-Gasser S, Lemaitre AL, Almairac F, Duffau H (2019) Functional compensation of the left inferior longitudinal fasciculus for picture naming. Cogn Neuropsychol 36(3–4):140–157. https://doi.org/10.1080/02643294.2018.1477749PubMedCrossRef

13.

Duffau H (2015) Stimulation mapping of white matter tracts to study brain functional connectivity. Nat Rev Neurol 11(5):255–265. https://doi.org/10.1038/nrneurol.2015.51CrossRef

14.

Yetkin O, Yetkin FZ, Haughton VM, Cox RW (1996) Use of functional MR to map language in multilingual volunteers. Am J Neuroradiol 17(3):473–477PubMed

15.

Roux F-E, Trémoulet MJ (2002) Organization of language areas in bilingual patients: a cortical stimulation study. J Neurosurg 97(4):857–864PubMedCrossRef

16.

Perani D, Paulesu E, Galles NS, Dupoux E, Dehaene S, Bettinardi V, Cappa SF, Fazio F, Mehler J (1998) The bilingual brain. Proficiency and age of acquisition of the second language. Brain 121(Pt 10):1841–1852. https://doi.org/10.1093/brain/121.10.1841PubMedCrossRef

17.

Bloch C, Kaiser A, Kuenzli E, Zappatore D, Haller S, Franceschini R, Luedi G, Radue EW, Nitsch C (2009) The age of second language acquisition determines the variability in activation elicited by narration in three languages in Broca's and Wernicke's area. Neuropsychologia 47(3):625–633. https://doi.org/10.1016/j.neuropsychologia.2008.11.009PubMedCrossRef

18.

Abutalebi J, Annoni J-M, Zimine I, Pegna AJ, Seghier ML, Lee-Jahnke H, Lazeyras F, Cappa SF, Khateb AJCC (2008) Language control and lexical competition in bilinguals: an event-related fMRI study. Cerebr Cortex 18(7):1496–1505CrossRef

19.

Briellmann RS, Saling MM, Connell AB, Waites AB, Abbott DF, Jackson GD (2004) A high-field functional MRI study of quadri-lingual subjects. Brain Lang 89(3):531–542PubMedCrossRef

20.

Perani D, Abutalebi J, Paulesu E, Brambati S, Scifo P, Cappa SF, Fazio F (2003) The role of age of acquisition and language usage in early, high-proficient bilinguals: an fMRI study during verbal fluency. Hum Brain Mapp 19(3):170–182PubMedPubMedCentralCrossRef

21.

Vingerhoets G, Van Borsel J, Tesink C, Van den Noort M, Deblaere K, Seurinck R, Vandemaele P, Achten EJN (2003) Multilingualism: an fMRI study. Neuroimage 20(4):2181–2196PubMedCrossRef

22.

Paradis M (2003) Differential use of cerebral mechanisms in bilinguals. In: Mack MTBM (ed) Mind, brain, and language: multidisciplinary perspectives. Lawrence Erlbaum, London, pp 351–370

23.

Sierpowska J, Fernandez-Coello A, Gomez-Andres A, Camins A, Castaner S, Juncadella M, Gabarros A, Rodriguez-Fornells A (2018) Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients. Cortex 99:78–92. https://doi.org/10.1016/j.cortex.2017.10.017PubMedCrossRef

24.

Walker JA, Quinones-Hinojosa A, Berger MS (2004) Intraoperative speech mapping in 17 bilingual patients undergoing resection of a mass lesion. Neurosurgery 54(1):113–117 discussion 118PubMedCrossRef

25.

Yokoyama S, Okamoto H, Miyamoto T, Yoshimoto K, Kim J, Iwata K, Jeong H, Uchida S, Ikuta N, Sassa Y, Nakamura W, Horie K, Sato S, Kawashima R (2006) Cortical activation in the processing of passive sentences in L1 and L2: an fMRI study. Neuroimage 30(2):570–579. https://doi.org/10.1016/j.neuroimage.2005.09.066PubMedCrossRef

26.

Halsband U (2006) Bilingual and multilingual language processing. J Physiol Paris 99(4–6):355–369. https://doi.org/10.1016/j.jphysparis.2006.03.016PubMedCrossRef

27.

Kousta ST, Vinson DP, Vigliocco G (2008) Investigating linguistic relativity through bilingualism: the case of grammatical gender. J Exp Psychol Learn Mem Cogn 34(4):843–858. https://doi.org/10.1037/0278-7393.34.4.843PubMedCrossRef

28.

McComsey M (2015) Bilingual spaces: approaches to linguistic relativity in Bilingual Mexico. University of California, San Diego

29.

Hernandez AE, Martinez A, Kohnert K (2000) In search of the language switch: an fMRI study of picture naming in Spanish-English bilinguals. Brain Lang 73(3):421–431. https://doi.org/10.1006/brln.1999.2278PubMedCrossRef

30.

Ojemann G, Ojemann J, Lettich E, Berger M (1989) Cortical language localization in left, dominant hemisphere. An electrical stimulation mapping investigation in 117 patients. J Neurosurg 71(3):316–326. https://doi.org/10.3171/jns.1989.71.3.0316PubMedCrossRef

31.

Van Buren JM, Fedio P, Frederick GC (1978) Mechanism and localization of speech in the parietotemporal cortex. Neurosurgery 2(3):233–239. https://doi.org/10.1227/00006123-197805000-00009PubMedCrossRef

32.

Bilotta F, Stazi E, Delfini R, Rosa G (2011) Language testing during awake "anesthesia" in a bilingual patient with brain lesion adjacent to Wernicke's area. Anesth Analg 112(4):938–939. https://doi.org/10.1213/ANE.0b013e31820bd1a4PubMedCrossRef

33.

Sanai N, Mirzadeh Z, Berger MS (2008) Functional outcome after language mapping for glioma resection. N Engl J Med 358(1):18–27. https://doi.org/10.1056/NEJMoa067819PubMedCrossRef

34.

Quinones-Hinojosa A, Ojemann SG, Sanai N, Dillon WP, Berger MS (2003) Preoperative correlation of intraoperative cortical mapping with magnetic resonance imaging landmarks to predict localization of the Broca area. J Neurosurg 99(2):311–318. https://doi.org/10.3171/jns.2003.99.2.0311PubMedCrossRef

35.

Ojemann SG, Berger MS, Lettich E, Ojemann GA (2003) Localization of language function in children: results of electrical stimulation mapping. J Neurosurg 98(3):465–470. https://doi.org/10.3171/jns.2003.98.3.0465PubMedCrossRef

36.

Berger MS (1996) Minimalism through intraoperative functional mapping. Clin Neurosurg 43:324–337PubMed

37.

Haglund MM, Berger MS, Shamseldin M, Lettich E, Ojemann GA (1994) Cortical localization of temporal lobe language sites in patients with gliomas. Neurosurgery 34(4):567–576 discussion 576PubMed

38.

Wesseling P, Capper D (2017) WHO 2016 classification of gliomas. Neuropathol Appl Neurobiol. https://doi.org/10.1111/nan.12432CrossRef

39.

Riggenbach H (1991) Toward an understanding of fluency: a microanalysis of nonnative speaker conversations. Discourse Process 14(4):423–441CrossRef

40.

Bosker HR, Pinget A-F, Quené H, Sanders T, De Jong NHJLT (2013) What makes speech sound fluent? The contributions of pauses, speed and repairs. Lang Test 30(2):159–175CrossRef

41.

Kahng JJLL (2014) Exploring utterance and cognitive fluency of L1 and L2 English speakers: temporal measures and stimulated recall. Lang Learn 64(4):809–854CrossRef

42.

Révész A, Ekiert M, Torgersen EN (2016) The effects of complexity, accuracy, and fluency on communicative adequacy in oral task performance. Appl Linguist 37(6):828–848

43.

Eseonu CI, Rincon-Torroella J, ReFaey K, Lee YM, Nangiana J, Vivas-Buitrago T, Quinones-Hinojosa A (2017) Awake craniotomy vs craniotomy under general anesthesia for perirolandic gliomas: evaluating perioperative complications and extent of resection. Neurosurgery. https://doi.org/10.1093/neuros/nyx023PubMedCrossRef

44.

Eseonu CI, ReFaey K, Garcia O, Raghuraman G, Quinones-Hinojosa A (2017) Volumetric analysis of extent of resection, survival, and surgical outcomes for insular gliomas. World Neurosurg 103:265–274. https://doi.org/10.1016/j.wneu.2017.04.002PubMedCrossRef

45.

ReFaey K, Chaichana KL, Feyissa AM, Vivas-Buitrago T, Brinkmann BH, Middlebrooks EH, McKay JH, Lankford DJ, Tripathi S, Bojaxhi E, Roth GE, Tatum WO, Quiñones-Hinojosa A (2019) A 360° electronic device for recording high-resolution intraoperative electrocorticography of the brain during awake craniotomy. J Neurosurg. https://doi.org/10.3171/2019.4.JNS19261PubMedCrossRef

46.

Chaichana KL, Jusue-Torres I, Lemos AM, Gokaslan A, Cabrera-Aldana EE, Ashary A, Olivi A, Quinones-Hinojosa A (2014) The butterfly effect on glioblastoma: is volumetric extent of resection more effective than biopsy for these tumors? J Neurooncol 120(3):625–634. https://doi.org/10.1007/s11060-014-1597-9PubMedPubMedCentralCrossRef

47.

Chaichana KL, Jusue-Torres I, Navarro-Ramirez R, Raza SM, Pascual-Gallego M, Ibrahim A, Hernandez-Hermann M, Gomez L, Ye X, Weingart JD, Olivi A, Blakeley J, Gallia GL, Lim M, Brem H, Quinones-Hinojosa A (2014) Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma. Neuro Oncol 16(1):113–122. https://doi.org/10.1093/neuonc/not137PubMedCrossRef

48.

Eseonu CI, Eguia F, ReFaey K, Garcia O, Rodriguez FJ, Chaichana K, Quinones-Hinojosa A (2017) Comparative volumetric analysis of the extent of resection of molecularly and histologically distinct low grade gliomas and its role on survival. J Neurooncol 134(1):65–74. https://doi.org/10.1007/s11060-017-2486-9PubMedCrossRef

49.

Eseonu CI, Rincon-Torroella J, ReFaey K, Quinones-Hinojosa A (2017) The cost of brain surgery: awake vs asleep craniotomy for perirolandic region tumors. Neurosurgery 81(2):307–314. https://doi.org/10.1093/neuros/nyx022PubMedCrossRef

50.

Tatum WO, McKay JH, ReFaey K, Feyissa AM, Ryan D, Ritaccio A, Middlebrooks E, Yelvington K, Roth G, Acton E, Grewal S, Chaichana K, Quinones-Hinojosa A (2020) Detection of after-discharges during intraoperative functional brain mapping in awake brain tumor surgery using a novel high-density circular grid. Clin Neurophysiol 131(4):828–835. https://doi.org/10.1016/j.clinph.2019.12.416PubMedCrossRef

51.

Arechiga N, Refaey K, Rincon-Torroella J, Chaichana KL, Quiñones-Hinojosa A (2016) Video atlas of neurosurgery: contemporary tumor and skull base surgery, vol 1 cortical/subcortical motor mapping for gliomas. Elsevier, Philadelphia

52.

Eseonu CI, Rincon-Torroella J, Lee YM, ReFaey K, Tripathi P, Quinones-Hinojosa A (2018) Intraoperative seizures in awake craniotomy for perirolandic glioma resections that undergo cortical mapping. J Neurol Surg A Cent Eur Neurosurg. https://doi.org/10.1055/s-0037-1617759PubMedCrossRef

53.

Eseonu CI, ReFaey K, Garcia O, John A, Quinones-Hinojosa A, Tripathi P (2017) Awake craniotomy anesthesia: a comparison of the monitored anesthesia care and asleep-awake-asleep techniques. World Neurosurg 104:679–686. https://doi.org/10.1016/j.wneu.2017.05.053PubMedCrossRef

54.

Nossek E, Matot I, Shahar T, Barzilai O, Rapoport Y, Gonen T, Sela G, Grossman R, Korn A, Hayat D, Ram Z (2013) Intraoperative seizures during awake craniotomy: incidence and consequences: analysis of 477 patients. Neurosurgery 73(1):135–140. https://doi.org/10.1227/01.neu.0000429847.91707.97discussion 140PubMedCrossRef

55.

Lima GLO, Dezamis E, Corns R, Rigaux-Viode O, Moritz-Gasser S, Roux A, Duffau H, Pallud J (2017) Surgical resection of incidental diffuse gliomas involving eloquent brain areas. Rationale, functional, epileptological and oncological outcomes. Neurochirurgie 63(3):250–258. https://doi.org/10.1016/j.neuchi.2016.08.007PubMedCrossRef

56.

Yuan Y, Peizhi Z, Xiang W, Yanhui L, Ruofei L, Shu J, Qing M (2016) Intraoperative seizures and seizures outcome in patients underwent awake craniotomy. J Neurosurg Sci 63:301PubMed

57.

Middlebrooks EH, Yagmurlu K, Szaflarski JP, Rahman M, Bozkurt B (2017) A contemporary framework of language processing in the human brain in the context of preoperative and intraoperative language mapping. Neuroradiology 59(1):69–87. https://doi.org/10.1007/s00234-016-1772-0PubMedCrossRef

58.

Yagmurlu K, Middlebrooks EH, Tanriover N, Rhoton AL Jr (2016) Fiber tracts of the dorsal language stream in the human brain. J Neurosurg 124(5):1396–1405. https://doi.org/10.3171/2015.5.JNS15455PubMedCrossRef

59.

Ojemann GA, Whitaker HA (1978) The bilingual brain. Arch Neurol 35(7):409–412. https://doi.org/10.1001/archneur.1978.00500310011002PubMedCrossRef

60.

Ojemann GA, Whitaker HA (1978) Language localization and variability. Brain Lang 6(2):239–260. https://doi.org/10.1016/0093-934x(78)90061-5PubMedCrossRef

61.

Rapport RL, Tan CT, Whitaker HA (1983) Language function and dysfunction among Chinese- and English-speaking polyglots: cortical stimulation, Wada testing, and clinical studies. Brain Lang 18(2):342–366. https://doi.org/10.1016/0093-934x(83)90024-xPubMedCrossRef

62.

Calabrese P, Neufeld H, Falk A, Markowitsch HJ, Muller C, Heuser L, Gehlen W, Durwen HF (2001) Word generation in bilinguals–fMRI study with implications for language and memory processes. Fortschr Neurol Psychiatr 69(1):42–49. https://doi.org/10.1055/s-2001-10467PubMedCrossRef

63.

Hernandez AE, Dapretto M, Mazziotta J, Bookheimer S (2001) Language switching and language representation in Spanish-English bilinguals: an fMRI study. Neuroimage 14(2):510–520. https://doi.org/10.1006/nimg.2001.0810PubMedCrossRef

64.

Roux FE, Lubrano V, Lauwers-Cances V, Tremoulet M, Mascott CR, Demonet JF (2004) Intra-operative mapping of cortical areas involved in reading in mono- and bilingual patients. Brain 127(Pt 8):1796–1810. https://doi.org/10.1093/brain/awh204PubMedCrossRef

65.

Tham WW, Rickard Liow SJ, Rajapakse JC, Choong Leong T, Ng SE, Lim WE, Ho LG (2005) Phonological processing in Chinese-English bilingual biscriptals: an fMRI study. Neuroimage 28(3):579–587. https://doi.org/10.1016/j.neuroimage.2005.06.057PubMedCrossRef

66.

Giussani C, Roux FE, Lubrano V, Gaini SM, Bello L (2007) Review of language organisation in bilingual patients: what can we learn from direct brain mapping? Acta Neurochir (Wien) 149(11):1109–1116. https://doi.org/10.1007/s00701-007-1266-2discussion 1116CrossRef

67.

Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S (2014) Intraoperative dorsal language network mapping by using single-pulse electrical stimulation. Hum Brain Mapp 35(9):4345–4361. https://doi.org/10.1002/hbm.22479PubMedPubMedCentralCrossRef

68.

Enatsu R, Kubota Y, Kakisaka Y, Bulacio J, Piao Z, O'Connor T, Horning K, Mosher J, Burgess RC, Bingaman W, Nair DR (2013) Reorganization of posterior language area in temporal lobe epilepsy: a cortico-cortical evoked potential study. Epilepsy Res 103(1):73–82. https://doi.org/10.1016/j.eplepsyres.2012.07.008PubMedCrossRef

69.

Catani M, Allin MP, Husain M, Pugliese L, Mesulam MM, Murray RM, Jones DK (2007) Symmetries in human brain language pathways correlate with verbal recall. Proc Natl Acad Sci USA 104(43):17163–17168. https://doi.org/10.1073/pnas.0702116104PubMedCrossRef

70.

Fernández-Coello A, Havas V, Juncadella M, Sierpowska J, Rodríguez-Fornells A, Gabarrós A (2017) Age of language acquisition and cortical language organization in multilingual patients undergoing awake brain mapping. J Neurosurg 126(6):1912–1923. https://doi.org/10.3171/2016.5.JNS152791PubMedCrossRef

71.

Sierpowska J, Gabarros A, Ripolles P, Juncadella M, Castaner S, Camins A, Plans G, Rodriguez-Fornells A (2013) Intraoperative electrical stimulation of language switching in two bilingual patients. Neuropsychologia 51(13):2882–2892. https://doi.org/10.1016/j.neuropsychologia.2013.09.003PubMedCrossRef

72.

Rivera-Rivera PA, Rios-Lago M, Sanchez-Casarrubios S, Salazar O, Yus M, Gonzalez-Hidalgo M, Sanz A, Avecillas-Chasin J, Alvarez-Linera J, Pascual-Leone A, Oliviero A, Barcia JA (2017) Cortical plasticity catalyzed by prehabilitation enables extensive resection of brain tumors in eloquent areas. J Neurosurg 126(4):1323–1333. https://doi.org/10.3171/2016.2.JNS152485PubMedCrossRef

73.

Deverdun J, van Dokkum LEH, Le Bars E, Herbet G, Mura T, D'Agata B, Picot MC, Menjot N, Molino F, Duffau H, Moritz Gasser S (2019) Language reorganization after resection of low-grade gliomas: an fMRI task based connectivity study. Brain Imaging Behav. https://doi.org/10.1007/s11682-019-00114-7PubMedCrossRef

74.

Gatignol P, Duffau H, Capelle L, Plaza M (2009) Naming performance in two bilinguals with frontal vs. temporal glioma. Neurocase 15(6):466–477. https://doi.org/10.1080/13554790902950434PubMedCrossRef

75.

Lucas TH, McKhann GM, Ojemann GA (2004) Functional separation of languages in the bilingual brain: a comparison of electrical stimulation language mapping in 25 bilingual patients and 117 monolingual control patients. J Neurosurg 101(3):449–457CrossRef

76.

Li P, Legault J, Litcofsky KA (2014) Neuroplasticity as a function of second language learning: anatomical changes in the human brain. Cortex 58:301–324. https://doi.org/10.1016/j.cortex.2014.05.001PubMedCrossRef

77.

Schafer RJ, Constable RT (2009) Variation in language networks in monolingual and bilingual English speakers: consequences for language mapping for surgical preplanning. J Clin Exp Neuropsychol 31(8):945–954. https://doi.org/10.1080/13803390902766879PubMedCrossRef

78.

Duffau H (2005) Lessons from brain mapping in surgery for low-grade glioma: insights into associations between tumour and brain plasticity. Lancet Neurol 4(8):476–486. https://doi.org/10.1016/S1474-4422(05)70140-XPubMedCrossRef

79.

Costello TG (2014) Awake craniotomy and multilingualism: language testing during anaesthesia for awake craniotomy in a bilingual patient. J Clin Neurosci 21(8):1469–1470. https://doi.org/10.1016/j.jocn.2013.11.053PubMedCrossRef

80.

Bello L, Acerbi F, Giussani C, Baratta P, Taccone P, Songa VJN (2006) Intraoperative language localizationin multilingual patients with gliomas. Neurosurgery 59(1):115–125PubMedCrossRef

81.

Cervenka MC, Boatman-Reich D, Ward J, Franaszczuk PJ, Crone N (2011) Language mapping in multilingual patients: electrocorticography and cortical stimulation during naming. Front Hum Neurosci 5:13PubMedPubMedCentralCrossRef

82.

Erturk Cetin O, Isler C, Uzan M, Ozkara C (2017) Epilepsy-related brain tumors. Seizure 44:93–97. https://doi.org/10.1016/j.seizure.2016.12.012PubMedCrossRef

Titel: Potential differences between monolingual and bilingual patients in approach and outcome after awake brain surgery
verfasst von: Karim ReFaey
Shashwat Tripathi
Adip G. Bhargav
Sanjeet S. Grewal
Erik H. Middlebrooks
David S. Sabsevitz
Mark Jentoft
Peter Brunner
Adela Wu
William O. Tatum
Anthony Ritaccio
Kaisorn L. Chaichana
Alfredo Quinones-Hinojosa
Publikationsdatum: 10.06.2020
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2020
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-020-03554-0

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