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Erschienen in: Infection 5/2019

22.03.2019 | Original Paper

Practices, organisation, and regulatory aspects in advising on antibiotic prescription: the international ESCMID AntibioLegalMap survey

verfasst von: Gianpiero Tebano, Oliver J. Dyar, Bojana Beovic, Frédérique Claudot, Guillaume Béraud, Nathalie Thilly, Céline Pulcini, European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Antimicrobial stewardshiP (ESGAP)

Erschienen in: Infection | Ausgabe 5/2019

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Abstract

Purpose

Giving advice about antibiotic prescription through dedicated consultations is a cornerstone of antibiotic stewardship programmes. Our objective was to explore practices, organisation, and regulatory requirements related to antibiotic advising.

Methods

We performed an international, exploratory, Internet-based, cross-sectional survey targeting infectious diseases and clinical microbiology specialists. It was disseminated through ESCMID and ESGAP networks.

Results

Answers from 830 participants (74 countries, 77% of participants from Europe) were collected. Consultations were mostly given on demand (81%, 619/764), while unsolicited consultations targeting specific conditions (e.g., positive blood culture) were less frequent (66%, 501/764). Consultations usually included indications on diagnostic work-up and follow-up (> 79%). Curbside consultations (i.e., without examining the patient) were reported by 82% (598/733) of respondents, mainly by phone (89%, 531/598). The referring physician was considered authorised not to follow the advice by 57% (383/676). Direct consultations (i.e., after examining the patient) were recorded in the medical file more frequently than curbside consultations (69%, 472/689 vs 35%, 206/592). Concerning legal liability, the majority of respondents considered that it is shared between the adviser and the referring physician, who, however, is considered primarily responsible. The advisers’ liability was considered to be lower in cases of curbside and unrecorded consultations. Significant inter-countries and intra-country variability were identified, suggesting that the setting markedly influenced practices.

Conclusion

Significant variability exists in the practice of antibiotic advising. This concerns both the organisation of care and how advisers perceive regulatory requirements. These elements must be taken into account when implementing antibiotic stewardship programmes and when training stewards.
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Literatur
1.
Zurück zum Zitat Bell BG, Schellevis F, Stobberingh E, Goossens H, Pringle M. A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance. BMC Infect Dis. 2014;14:13.CrossRef Bell BG, Schellevis F, Stobberingh E, Goossens H, Pringle M. A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance. BMC Infect Dis. 2014;14:13.CrossRef
2.
Zurück zum Zitat Dyar OJ, Obua C, Chandy S, Xiao Y, Stålsby Lundborg C, Pulcini C. Using antibiotics responsibly: are we there yet? Future Microbiol. 2016;11:1057–71.CrossRef Dyar OJ, Obua C, Chandy S, Xiao Y, Stålsby Lundborg C, Pulcini C. Using antibiotics responsibly: are we there yet? Future Microbiol. 2016;11:1057–71.CrossRef
3.
Zurück zum Zitat Laxminarayan R, Duse A, Wattal C, Zaidi AKM, Wertheim HFL, Sumpradit N, et al. Antibiotic resistance-the need for global solutions. Lancet Infect Dis. 2013;13:1057–98.CrossRef Laxminarayan R, Duse A, Wattal C, Zaidi AKM, Wertheim HFL, Sumpradit N, et al. Antibiotic resistance-the need for global solutions. Lancet Infect Dis. 2013;13:1057–98.CrossRef
4.
Zurück zum Zitat Dellit TH, Owens RC, McGowan JE, Gerding DN, Weinstein RA, Burke JP, et al. Infectious diseases society of America and the society for healthcare epidemiology of America Guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007;44:159–77.CrossRef Dellit TH, Owens RC, McGowan JE, Gerding DN, Weinstein RA, Burke JP, et al. Infectious diseases society of America and the society for healthcare epidemiology of America Guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007;44:159–77.CrossRef
5.
Zurück zum Zitat Pulcini C, Binda F, Lamkang AS, Trett A, Charani E, Goff DA, et al. Developing core elements and checklist items for global hospital antimicrobial stewardship programmes: a consensus approach. Clin Microbiol Infect. 2019;25:20–5.CrossRef Pulcini C, Binda F, Lamkang AS, Trett A, Charani E, Goff DA, et al. Developing core elements and checklist items for global hospital antimicrobial stewardship programmes: a consensus approach. Clin Microbiol Infect. 2019;25:20–5.CrossRef
6.
Zurück zum Zitat Howard P, Pulcini C, Levy Hara G, West RM, Gould IM, Harbarth S, et al. An international cross-sectional survey of antimicrobial stewardship programmes in hospitals. J Antimicrob Chemother. 2015;70:1245–55.PubMed Howard P, Pulcini C, Levy Hara G, West RM, Gould IM, Harbarth S, et al. An international cross-sectional survey of antimicrobial stewardship programmes in hospitals. J Antimicrob Chemother. 2015;70:1245–55.PubMed
7.
Zurück zum Zitat Pulcini C, Botelho-Nevers E, Dyar OJ, Harbarth S. The impact of infectious disease specialists on antibiotic prescribing in hospitals. Clin Microbiol Infect. 2014;20:963–72.CrossRef Pulcini C, Botelho-Nevers E, Dyar OJ, Harbarth S. The impact of infectious disease specialists on antibiotic prescribing in hospitals. Clin Microbiol Infect. 2014;20:963–72.CrossRef
8.
Zurück zum Zitat Flottorp SA, Oxman AD, Krause J, Musila NR, Wensing M, Godycki-Cwirko M, et al. A checklist for identifying determinants of practice: a systematic review and synthesis of frameworks and taxonomies of factors that prevent or enable improvements in healthcare professional practice. Implement Sci. 2013;8:35.CrossRef Flottorp SA, Oxman AD, Krause J, Musila NR, Wensing M, Godycki-Cwirko M, et al. A checklist for identifying determinants of practice: a systematic review and synthesis of frameworks and taxonomies of factors that prevent or enable improvements in healthcare professional practice. Implement Sci. 2013;8:35.CrossRef
9.
Zurück zum Zitat Tebano G, Dyar OJ, Beovic B, Béraud G, Thilly N, Pulcini C, et al. Defensive medicine among antibiotic stewards: the international ESCMID AntibioLegalMap survey. J Antimicrob Chemother. 2018;73:1989–96.CrossRef Tebano G, Dyar OJ, Beovic B, Béraud G, Thilly N, Pulcini C, et al. Defensive medicine among antibiotic stewards: the international ESCMID AntibioLegalMap survey. J Antimicrob Chemother. 2018;73:1989–96.CrossRef
11.
Zurück zum Zitat Beovic B, Kreft S, Seme K, Cizman M. The impact of total control of antibiotic prescribing by infectious disease specialist on antibiotic consumption and cost. J Chemother Florence Italy. 2009;21:46–51.CrossRef Beovic B, Kreft S, Seme K, Cizman M. The impact of total control of antibiotic prescribing by infectious disease specialist on antibiotic consumption and cost. J Chemother Florence Italy. 2009;21:46–51.CrossRef
12.
Zurück zum Zitat Uçkay I, Vernaz-Hegi N, Harbarth S, Stern R, Legout L, Vauthey L, et al. Activity and impact on antibiotic use and costs of a dedicated infectious diseases consultant on a septic orthopaedic unit. J Infect. 2009;58:205–12.CrossRef Uçkay I, Vernaz-Hegi N, Harbarth S, Stern R, Legout L, Vauthey L, et al. Activity and impact on antibiotic use and costs of a dedicated infectious diseases consultant on a septic orthopaedic unit. J Infect. 2009;58:205–12.CrossRef
13.
Zurück zum Zitat Jenkins TC, Price CS, Sabel AL, Mehler PS, Burman WJ. Impact of routine infectious diseases service consultation on the evaluation, management, and outcomes of Staphylococcus aureus bacteremia. Clin Infect Dis. 2008;46:1000–8.CrossRef Jenkins TC, Price CS, Sabel AL, Mehler PS, Burman WJ. Impact of routine infectious diseases service consultation on the evaluation, management, and outcomes of Staphylococcus aureus bacteremia. Clin Infect Dis. 2008;46:1000–8.CrossRef
14.
Zurück zum Zitat Bouza E, Sousa D, Muñoz P, Rodríguez-Créixems M, Fron C, Lechuz JG. Bloodstream infections: a trial of the impact of different methods of reporting positive blood culture results. Clin Infect Dis. 2004;39:1161–9.CrossRef Bouza E, Sousa D, Muñoz P, Rodríguez-Créixems M, Fron C, Lechuz JG. Bloodstream infections: a trial of the impact of different methods of reporting positive blood culture results. Clin Infect Dis. 2004;39:1161–9.CrossRef
15.
Zurück zum Zitat Dickstein Y, Nir-Paz R, Pulcini C, Cookson B, Beović B, Tacconelli E, et al. Staffing for infectious diseases, clinical microbiology and infection control in hospitals in 2015: results of an ESCMID member survey. Clin Microbiol Infect. 2016;22:812.e9–812.e17.CrossRef Dickstein Y, Nir-Paz R, Pulcini C, Cookson B, Beović B, Tacconelli E, et al. Staffing for infectious diseases, clinical microbiology and infection control in hospitals in 2015: results of an ESCMID member survey. Clin Microbiol Infect. 2016;22:812.e9–812.e17.CrossRef
16.
Zurück zum Zitat Dyar OJ, Huttner B, Schouten J, Pulcini C. ESGAP (ESCMID Study Group for Antimicrobial stewardshiP). What is antimicrobial stewardship? Clin Microbiol Infect. 2017;23:793–98.CrossRef Dyar OJ, Huttner B, Schouten J, Pulcini C. ESGAP (ESCMID Study Group for Antimicrobial stewardshiP). What is antimicrobial stewardship? Clin Microbiol Infect. 2017;23:793–98.CrossRef
17.
Zurück zum Zitat Diallo Kévin T, Nathalie L, Amandine B, Guillaume E, Önder M, Giannella, et al. Management of bloodstream infections by infection specialists: an international ESCMID cross-sectional survey. Int J Antimicrob Agents. 2018;51:794–98.CrossRef Diallo Kévin T, Nathalie L, Amandine B, Guillaume E, Önder M, Giannella, et al. Management of bloodstream infections by infection specialists: an international ESCMID cross-sectional survey. Int J Antimicrob Agents. 2018;51:794–98.CrossRef
18.
Zurück zum Zitat Ingram PR, Cheng AC, Murray RJ, Blyth CC, Walls T, Fisher DA, et al. What do infectious diseases physicians do? A 2-week snapshot of inpatient consultative activities across Australia, New Zealand and Singapore. Clin Microbiol Infect. 2014;20:737–44.CrossRef Ingram PR, Cheng AC, Murray RJ, Blyth CC, Walls T, Fisher DA, et al. What do infectious diseases physicians do? A 2-week snapshot of inpatient consultative activities across Australia, New Zealand and Singapore. Clin Microbiol Infect. 2014;20:737–44.CrossRef
19.
Zurück zum Zitat Rieg S, Hitzenbichler F, Hagel S, Suarez I, Kron F, Salzberger B, et al. Infectious disease services: a survey from four university hospitals in Germany. Infection. 2019;47:27–33.CrossRef Rieg S, Hitzenbichler F, Hagel S, Suarez I, Kron F, Salzberger B, et al. Infectious disease services: a survey from four university hospitals in Germany. Infection. 2019;47:27–33.CrossRef
20.
Zurück zum Zitat Manian FA, McKinsey DS. A prospective study of 2,092 “curbside” questions asked of two infectious disease consultants in private practice in the midwest. Clin Infect Dis. 1996;22:303–7.CrossRef Manian FA, McKinsey DS. A prospective study of 2,092 “curbside” questions asked of two infectious disease consultants in private practice in the midwest. Clin Infect Dis. 1996;22:303–7.CrossRef
21.
Zurück zum Zitat Sellier E, Pavese P, Gennai S, Stahl J-P, Labarère J, François P. Factors and outcomes associated with physicians’ adherence to recommendations of infectious disease consultations for inpatients. J Antimicrob Chemother. 2010;65:156–62.CrossRef Sellier E, Pavese P, Gennai S, Stahl J-P, Labarère J, François P. Factors and outcomes associated with physicians’ adherence to recommendations of infectious disease consultations for inpatients. J Antimicrob Chemother. 2010;65:156–62.CrossRef
22.
Zurück zum Zitat Forsblom E, Ruotsalainen E, Ollgren J, Järvinen A. Telephone consultation cannot replace bedside infectious disease consultation in the management of Staphylococcus aureus bacteremia. Clin Infect Dis. 2013;56:527–35.CrossRef Forsblom E, Ruotsalainen E, Ollgren J, Järvinen A. Telephone consultation cannot replace bedside infectious disease consultation in the management of Staphylococcus aureus bacteremia. Clin Infect Dis. 2013;56:527–35.CrossRef
23.
Zurück zum Zitat Cook DA, Sorensen KJ, Wilkinson JM. Value and process of curbside consultations in clinical practice: a grounded theory study. Mayo Clin Proc. 2014;89:602–14.CrossRef Cook DA, Sorensen KJ, Wilkinson JM. Value and process of curbside consultations in clinical practice: a grounded theory study. Mayo Clin Proc. 2014;89:602–14.CrossRef
24.
Zurück zum Zitat Grace C, Alston WK, Ramundo M, Polish L, Kirkpatrick B, Huston C. The complexity, relative value, and financial worth of curbside consultations in an academic infectious diseases unit. Clin Infect Dis. 2010;51:651–5.CrossRef Grace C, Alston WK, Ramundo M, Polish L, Kirkpatrick B, Huston C. The complexity, relative value, and financial worth of curbside consultations in an academic infectious diseases unit. Clin Infect Dis. 2010;51:651–5.CrossRef
25.
Zurück zum Zitat Linkin DR, Fishman NO, Landis JR, Barton TD, Gluckman S, Kostman J, et al. Effect of communication errors during calls to an antimicrobial stewardship program. Infect Control Hosp Epidemiol. 2007;28:1374–81.CrossRef Linkin DR, Fishman NO, Landis JR, Barton TD, Gluckman S, Kostman J, et al. Effect of communication errors during calls to an antimicrobial stewardship program. Infect Control Hosp Epidemiol. 2007;28:1374–81.CrossRef
26.
Zurück zum Zitat Yam P, Fales D, Jemison J, Gillum M, Bernstein M. Implementation of an antimicrobial stewardship program in a rural hospital. Am J Health-Syst Pharm. 2012;69:1142–8.CrossRef Yam P, Fales D, Jemison J, Gillum M, Bernstein M. Implementation of an antimicrobial stewardship program in a rural hospital. Am J Health-Syst Pharm. 2012;69:1142–8.CrossRef
27.
Zurück zum Zitat Shanks L, Masumbuko EW, Ngoy NM, Maneno M, Bartlett S, Thi SS, et al. Treatment of multidrug-resistant tuberculosis in a remote, conflict-affected area of the Democratic Republic of Congo. Int J Tuberc Lung Dis. 2012;16:1066–8.CrossRef Shanks L, Masumbuko EW, Ngoy NM, Maneno M, Bartlett S, Thi SS, et al. Treatment of multidrug-resistant tuberculosis in a remote, conflict-affected area of the Democratic Republic of Congo. Int J Tuberc Lung Dis. 2012;16:1066–8.CrossRef
30.
Zurück zum Zitat Fox BC, Siegel ML, Weinstein RA. “Curbside” Consultation and Informal Communication in Medical Practice: A Medicolegal Perspective. Clin Infect Dis. 1996;23:616–22.CrossRef Fox BC, Siegel ML, Weinstein RA. “Curbside” Consultation and Informal Communication in Medical Practice: A Medicolegal Perspective. Clin Infect Dis. 1996;23:616–22.CrossRef
31.
Zurück zum Zitat Manian FA, Janssen DA. Curbside consultations. A closer look at a common practice. JAMA. 1996;275:145–7.CrossRef Manian FA, Janssen DA. Curbside consultations. A closer look at a common practice. JAMA. 1996;275:145–7.CrossRef
Metadaten
Titel
Practices, organisation, and regulatory aspects in advising on antibiotic prescription: the international ESCMID AntibioLegalMap survey
verfasst von
Gianpiero Tebano
Oliver J. Dyar
Bojana Beovic
Frédérique Claudot
Guillaume Béraud
Nathalie Thilly
Céline Pulcini
European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Antimicrobial stewardshiP (ESGAP)
Publikationsdatum
22.03.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Infection / Ausgabe 5/2019
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-019-01298-2

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