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Current Hematologic Malignancy Reports
Erschienen in: Current Hematologic Malignancy Reports 4/2013

01.12.2013 | Myeloproliferative Disorders (JJ Kiladjian, Section Editor)

Preclinical Models for Drug Selection in Myeloproliferative Neoplasms

verfasst von: Niccolò Bartalucci, Costanza Bogani, Alessandro M. Vannucchi

Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 4/2013

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Abstract

The discovery that an abnormally activated JAK-STAT signaling pathway is central to the pathogenesis of myeloproliferative neoplasms has promoted the clinical development of small-molecule JAK2 inhibitors. These agents have shown remarkable efficacy in disease control, but do not induce molecular remission; on the other hand, interferon holds the promise to target the putative hematopoietic progenitor cell initiating the disease. The presence of additional molecular abnormalities indicates a high molecular complexity of myeloproliferative neoplasms, and the need for simultaneously targeting different targets. Several drugs are currently under study as single agents and in combination. This review briefly describes the several in vitro and in vivo models of myeloproliferative neoplasms that are being used as preclinical models for drug development.
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Metadaten
Titel
Preclinical Models for Drug Selection in Myeloproliferative Neoplasms
verfasst von
Niccolò Bartalucci
Costanza Bogani
Alessandro M. Vannucchi
Publikationsdatum
01.12.2013
Verlag
Springer US
Erschienen in
Current Hematologic Malignancy Reports / Ausgabe 4/2013
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X
DOI
https://doi.org/10.1007/s11899-013-0182-1

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