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Journal of Cancer Research and Clinical Oncology

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29.08.2023 | Research

Predicting the prognosis of operable gastric cancer patients by dynamic changes in platelets before and after surgery: a retrospective cohort study

verfasst von: Jiante Li, Xinxin Yang, Xiang Wang, Yiwei Jiang, Zhonglin Wang, Xian Shen, Zhaoshen Li

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 17/2023

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Abstract

Purpose

Since the relationship between postoperative platelet count and prognosis is still unclear, we designed a standardized index of platelet count to predict the prognosis of gastric cancer (GC).

Methods

We designed a development validation cohort for the pre/post platelet ratio. We determined the ability of PPR to predict mortality in gastric cancer patients and validated them by a separate cohort. Survival was assessed by Kaplan–Meier analysis and associations explored by multivariate and multivariate analyses. The usefulness of the prediction was estimated by measuring the time-dependent ROC. Decision-curve analysis was used to validate the net clinical benefit.

Results

The sample distribution was similar in the two cohorts, and the 1-, 3-, and 5-year OS evaluation of the postoperative/preoperative platelet ratio was the largest for AUC in the two cohorts. Meanwhile, PPR has a good predictive value and a net clinical benefit.

Conclusions

PPR has been identified and validated to be independently concerned about OS of patients with GC and was a reliable and economic indicator to evaluate the prognosis.

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Titel: Predicting the prognosis of operable gastric cancer patients by dynamic changes in platelets before and after surgery: a retrospective cohort study
verfasst von: Jiante Li
Xinxin Yang
Xiang Wang
Yiwei Jiang
Zhonglin Wang
Xian Shen
Zhaoshen Li
Publikationsdatum: 29.08.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 17/2023
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-023-05334-5

Springer Medizin

Predicting the prognosis of operable gastric cancer patients by dynamic changes in platelets before and after surgery: a retrospective cohort study

Abstract

Purpose

Methods

Results

Conclusions

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Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

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Update Onkologie

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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