Background
Methods
Patients
Variables
Preserved vs. GA/fibrotic scar | GA vs. fibrotic scar | |
---|---|---|
Characteristics |
n = 194 |
n = 153 |
Mean age (years) | 78.01 | 78.68 |
Sex (n) | ||
Male | 78 | 89 |
Female | 116 | 64 |
Affected eye (n) | ||
Right | 101 | 88 |
Left | 93 | 65 |
Year of diagnosis (n) | ||
2007 | 4 | 3 |
2008 | 49 | 39 |
2009 | 101 | 85 |
2010 | 40 | 26 |
Delay of treatment (n) | ||
< 30 days | 128 | 99 |
(30–90] days | 50 | 43 |
> 90 days | 16 | 11 |
Angiographic type of lesion (n) | ||
Classic | 43 | 36 |
Predominantly classic | 13 | 11 |
Minimally classic | 14 | 13 |
Occult | 62 | 45 |
Others | 3 | 2 |
Status of the fellow eye (n) | ||
Initial/intermediate AMD | 75 | 54 |
Neovascular | 13 | 9 |
Atrophic | 38 | 36 |
Disciform scar | 37 | 30 |
Others | 21 | 15 |
Status of the lens (n) | ||
Cataract | 108 | 88 |
Pseudophakia | 53 | 40 |
Transparent | 7 | 3 |
Statistical analysis
Results
Preserved vs. GA/fibrotic scar
Baseline | 3 months | |||||||||
n (%) | OR | CI 95% |
p-value | n (%) | OR | IC 95% |
p-value | |||
Age | 194 |
0.9473
|
0.9058
|
0.9907
|
0.018
| - | - | - | - | - |
Sex | ||||||||||
Female | 116 (59.79) | 1 | - | - | - | - | - | - | - | - |
Male | 78 (40.21) | 0.7211 | 0.3506 | 0.1.4829 | 0.374 | - | - | - | - | - |
Year of diagnosis | ||||||||||
2007 | 4 (2.06) | 0.619 | 0.0588 | 6.5209 | 0.6897 | - | - | - | - | - |
2008 | 49 (25.26) | 0.4762 | 0.1839 | 1.2328 | 0.1263 | - | - | - | - | - |
2009 | 101 (52.06) |
0.3496
|
0.1508
|
0.8106
|
0.0143
| - | - | - | - | - |
2010 | 40 (20.62) | 1 | - | - | - | - | - | - | - | - |
Delay of treatment | ||||||||||
< 30 days | 128 (65.98) | 1 | - | - | - | - | - | - | - | - |
(30–90] days | 50 (25.77) | 0.5557 | 0.226 | 1.3664 | 0.2006 | - | - | - | - | - |
> 90 days | 16 (8.25) | 1.5517 | 0.4986 | 4.8289 | 0.4481 | - | - | - | - | - |
Angiographic type of lesion | ||||||||||
Classic | 43 (31.85) | 0.5147 | 0.1925 | 1.3759 | 0.1855 | - | - | - | - | - |
Predominantly classic | 13 (9.63) | 0.4813 | 0.0965 | 2.3997 | 0.3723 | - | - | - | - | - |
Minimally classic | 14 (10.37) | 0.2036 | 0.0247 | 1.678 | 0.1391 | - | - | - | - | - |
Occult | 62 (45.93) | 1 | - | - | - | - | - | - | - | - |
Others | 3 (2.22) | 1.3235 | 0.1126 | 15.5608 | 0.8236 | - | - | - | - | - |
Status of the fellow eye | ||||||||||
Initial/intermediate AMD | 75 (40.76) | 1 | - | - | - | - | - | - | - | - |
Neovascular | 13 (7.07) | 1.1429 | 0.3174 | 4.115 | 0.8381 | - | - | - | - | - |
Atrophic | 38 (20.65) |
0.1429
|
0.0315
|
0.6469
|
0.0116
| - | - | - | - | - |
Disciform scar | 37 (20.11) | 0.6 | 0.2286 | 1.5746 | 0.2994 | - | - | - | - | - |
Others | 21 (11.41) | 1.0286 | 0.3519 | 3.0064 | 0.9589 | - | - | - | - | - |
Status of the lens | ||||||||||
Cataract | 108 (64.29) | 1 | - | - | - | - | - | - | - | - |
Pseudophakia | 53 (31.55) | 1.43 | 0.6477 | 3.1572 | 0.3761 | - | - | - | - | - |
Transparent | 7 (4.17) |
5.8667
|
1.216
|
28.3039
|
0.0276
| - | - | - | - | - |
BCVA | 194 |
0.1296
|
0.0477
|
0.3517
|
0.0001
| 194 |
0.0668
|
0.0194
|
0.2301
|
<0.0001
|
CMT change | - | - | - | - | - | 191 | 0.8438 | 0.2975 | 2.3933 | 0.7496 |
OCT assessment | ||||||||||
SRF | 49 (28) | 0.4263 | 0.0917 | 1.9823 | 0.2769 | 60 (31.91) | 1.3636 | 0.6457 | 2.8796 | 0.4161 |
Thickening | 21 (12) | 4.05 | 0.5372 | 30.5344 | 0.1748 | 7 (3.72) | - | - | - | 0.9867 |
Both | 101 (57.71) | 1 | - | - | - | 9 (4.79) | 0.5114 | 0.0607 | 4.3051 | 0.5372 |
None | 4 (2.29) | 1.7868 | 0.819 | 3.8982 | 0.1448 | 112 (59.57) | 1 | - | - | - |
Macular associated lesions | ||||||||||
Bleeding >50% | 20 (14.6) | 0.402 | 0.1046 | 1.5454 | 0.1847 | 5 (4.24) | 0.6964 | 0.0716 | 6.7734 | 0.7553 |
PED | 37 (27.01) | 0.3559 | 0.1193 | 1.0621 | 0.064 | 23 (19.49) | 0.2653 | 0.055 | 1.28 | 0.0984 |
RPE tear | 2 (1.46) | - | - | - | 0.9969 | 3 (2.54) | - | - | - | 0.9976 |
Initial minimal atrophy | 5 (3.65) | - | - | - | 0.9951 | 8 (6.78) | - | - | - | 0.9961 |
Initial minimal fibrosis | 10 (7.3) | - | - | - | 0.9931 | 23 (19.49) | - | - | - | 0.9934 |
RAP | 2 (1.46) | 2.2778 | 0.1349 | 38.4694 | 0.5681 | 2 (1.69) | 2.7857 | 0.163 | 47.597 | 0.4793 |
PV | 2 (1.46) | - | - | - | 0.9969 | 1 (0.85) | - | - | - | 0.9985 |
Others | 59 (43.07) | - | - | - | - | 53 (44.92) | - | - | - | - |
Total time of treatment | - | - | - | - | - | - | - | - | - | - |
Number of injections | - | - | - | - | - | 194 | 1.9616 | 0.9564 | 4.0233 | 0.066 |
Number of visits | - | - | - | - | - | 170 | 1.4041 | 0.8748 | 2.2536 | 0.1598 |
1 year | 2 years | |||||||||
n (%) | OR | CI 95% |
p-value | n (%) | OR | CI 95% |
p-value | |||
Age | - | - | - | - | - | - | - | - | - | - |
Sex | ||||||||||
Female | - | - | - | - | - | - | - | - | - | - |
Male | - | - | - | - | - | - | - | - | - | - |
Year of diagnosis | ||||||||||
2007 | - | - | - | - | - | - | - | - | - | - |
2008 | - | - | - | - | - | - | - | - | - | - |
2009 | - | - | - | - | - | - | - | - | - | - |
2010 | - | - | - | - | - | - | - | - | - | - |
Delay of treatment | ||||||||||
< 30 days | - | - | - | - | - | - | - | - | - | - |
(30–90] days | - | - | - | - | - | - | - | - | - | - |
> 90 days | - | - | - | - | - | - | - | - | - | - |
Angiographic type of lesion | ||||||||||
Classic | - | - | - | - | - | - | - | - | - | - |
Predominantly classic | - | - | - | - | - | - | - | - | - | - |
Minimally classic | - | - | - | - | - | - | - | - | - | - |
Occult | - | - | - | - | - | - | - | - | - | - |
Others | - | - | - | - | - | - | - | - | - | - |
Status of the fellow eye | ||||||||||
Initial/intermediate AMD | - | - | - | - | - | - | - | - | - | - |
Neovascular | - | - | - | - | - | - | - | - | - | - |
Atrophic | - | - | - | - | - | - | - | - | - | - |
Disciform | - | - | - | - | - | - | - | - | - | - |
Others | - | - | - | - | - | - | - | - | - | - |
Status of the fellow eye | ||||||||||
Cataract | - | - | - | - | - | - | - | - | - | - |
Pseudophakia | - | - | - | - | - | - | - | - | - | - |
Transparent | - | - | - | - | - | - | - | - | - | - |
BCVA | 194 |
0.0227
|
0.0058
|
0.0891
|
<0.0001
| 194 |
0.0694
|
0.026
|
0.1851
|
<0.0001
|
CMT change | 192 | 0.5216 | 0.1953 | 1.3932 | 0.1941 | 192 | 1.3015 | 0.5533 | 3.0618 | 0.546 |
OCT assessment | ||||||||||
SRF | 52 (27.96) | 0.6667 | 0.2882 | 1.542 | 0.2769 | 33 (18.33) | 1.5 | 0.6232 | 3.6105 | 0.3656 |
Thickening | 11 (5.91) | 0.7078 | 0.1441 | 3.478 | 0.1748 | 6 (3.33) | 2 | 0.3472 | 11.52 | 0.4378 |
Both | 10 (5.38) | 0.3539 | 0.0429 | 2.9208 | - | 11 (6.11) | 0.8889 | 0.181 | 4.3646 | 0.8847 |
None | 113 (60.75) | 1 | - | - | 0.1448 | 130 (72.22) | 1 | - | - | - |
Macular associated lesions | ||||||||||
Bleeding >50% | 1 (0.76) | - | - | . | 0.9986 | 1 (0.75) | - | - | - | 0.9986 |
PED | 17 (12.88) |
0.0882
|
0.0107
|
0.7305
|
0.0244
| 18 (13.43) |
0.2267
|
0.0547
|
0.9385
|
0.0406
|
RPE tear | 4 (3.03) | 0.4706 | 0.045 | 4.9191 | 0.529 | 2 (1.49) | - | - | - | 0.998 |
Initial minimal atrophy | 22 (16.67) |
0.1412
|
0.0291
|
0.6859
|
0.0152
| 26 (19.4) | - | - | - | 0.9926 |
Initial minimal fibrosis | 47 (33.61) | - | - | - | 0.9902 | 54 (40.3) |
0.0436
|
0.009
|
0.2103
|
0.0001
|
RAP | 0 (0) | - | - | - | - | 0 (0) | - | - | - | - |
PV | 0 (0) | - | - | - | - | 1 (0.75) | - | - | - | 0.9986 |
Others | 41 (31.06) | 1 | - | - | - | 32 (23.88) | 1 | - | - | - |
Total time of treatment | - | - | - | - | - | - | - | - | - | - |
Number of injections | 194 | 1.2133 | 0.9583 | 1.5362 | - | 189 | 1.1721 | 0.9163 | 1.4992 | 0.2062 |
Number of visits | 184 | 1.1135 | 0.9391 | 1.3202 | - | 187 | 1.0613 | 0.9327 | 1.2076 | 0.3666 |
3 years | 4 years | |||||||||
n (%) | OR | CI 95% |
p-value | n (%) | OR | CI 95% |
p-value | |||
Age | - | - | - | - | - | - | - | - | - | - |
Sex | ||||||||||
Female | - | - | - | - | - | - | - | - | - | - |
Male | - | - | - | - | - | - | - | - | - | - |
Year of diagnosis | ||||||||||
2007 | - | - | - | - | - | - | - | - | - | - |
2008 | - | - | - | - | - | - | - | - | - | - |
2009 | - | - | - | - | - | - | - | - | - | - |
2010 | - | - | - | - | - | - | - | - | - | - |
Delay of treatment | ||||||||||
< 30 days | - | - | - | - | - | - | - | - | - | - |
(30–90] days | - | - | - | - | - | - | - | - | - | - |
> 90 days | - | - | - | - | - | - | - | - | - | - |
Angiographic type of lesion | ||||||||||
Classic | - | - | - | - | - | - | - | - | - | - |
Predominantly classic | - | - | - | - | - | - | - | - | - | - |
Minimally classic | - | - | - | - | - | - | - | - | - | - |
Occult | - | - | - | - | - | - | - | - | - | - |
Others | - | - | - | - | - | - | - | - | - | - |
Status of the fellow eye | ||||||||||
Initial/intermediate AMD | - | - | - | - | - | 50 (27.17) | 1 | - | - | - |
Neovascular | - | - | - | - | - | 21 (11.41) |
0.075
|
0.0093
|
0.6042
|
0.015
|
Atrophic | - | - | - | - | - | 50 (27.17) |
0.1304
|
0.0406
|
0.4194
|
0.0006
|
Disciform scar | - | - | - | - | - | 44 (23.91) |
0.3857
|
0.1529
|
0.9733
|
0.0437
|
Others | - | - | - | - | - | 19 (10.33) | 0.6923 | 0.2257 | 2.1232 | 0.5201 |
Status of the lens | ||||||||||
Cataract | - | - | - | - | - | - | - | - | - | - |
Pseudophakia | - | - | - | - | - | - | - | - | - | - |
Transparent | - | - | - | - | - | - | - | - | - | - |
BCVA | 194 |
0.0523
|
0.0182
|
0.1501
|
<0.0001
| 194 |
0.0595
|
0.0219
|
0.1616
|
<0.0001
|
CMT change | 192 | 1.2116 | 0.5475 | 2.6811 | 0.6358 | 192 | 1.3213 | 0.6428 | 2.7159 | 0.4485 |
OCT assessment | ||||||||||
SRF | 19 (14.62) | 0.9576 | 0.2885 | 3.1789 | 0.9435 | 5 (7.68) | - | - | - | 0.9926 |
Thickening | 5 (3.85) | 0.8977 | 0.0954 | 8.4467 | 0.9248 | 1 (1.52) | - | - | - | 0.9962 |
Both | 5 (3.85) | 5.3864 | 0.8465 | 34.2744 | 0.0745 | 3 (4.55) | 1.5357 | 0.1292 | 18.248 | 0.7341 |
None | 101 (77.69) | 1 | - | - | - | 57 (86.36) | 1 | - | - | - |
Macular associated lesions | ||||||||||
Bleeding >50% | 0 (0) | - | - | - | - | 0 (0) | - | - | - | - |
PED | 9 (8.65) | 0.1136 | 0.012 | 1.0764 | 0.058 | 1 (1.82) | - | - | - | 0.9963 |
RPE tear | 3 (2.28) | - | - | - | 0.9975 | 1 (1.82) | - | - | - | 0.9963 |
Initial minimal atrophy | 26 (25) | - | - | - | 0.9926 | 13 (23.64) |
0.0417
|
0.0035
|
0.4908
|
0.0115
|
Initial minimal fibrosis | 45 (43.27) |
0.0423
|
0.0081
|
0.2216
|
0.0002
| 31 (56.36) |
0.0167
|
0.0015
|
0.1887
|
0.0009
|
RAP | 0 (0) | - | - | - | - | 0 (0) | - | - | - | - |
PV | 0 (0) | - | - | - | - | 0 (0) | - | - | - | - |
Others | 21 (20.19) | 1 | - | - | - | 9 (16.36) | 1 | - | - | - |
Total time of treatment | - | - | - | - | - | 194 | 1.0131 | 0.982 | 1.0453 | 0.4134 |
Number of injections | 147 | 1.0238 | 0.8646 | 1.2122 | 0.7852 | 71 | 1.0032 | 0.8306 | 1.2116 | 0.9738 |
Number of visits | 147 | 1.1359 | 0.9571 | 1.3482 | 0.1448 | 76 | 0.9568 | 0.7498 | 1.2211 | 0.7229 |
Geographic atrophy vs. fibrotic scar
Baseline | 3 months | |||||||||
n (%) | OR | CI 95% |
p-value | n (%) | OR | CI 95% |
p-value | |||
Age | 153 | 1.0119 | 0.9678 | 1.058 | 0.6024 | - | - | - | - | - |
Sex | ||||||||||
Female | 89 (58.17) | 1 | - | - | - | - | - | - | - | - |
Male | 64 (41.83) |
0.4579
|
0.2368
|
0.8857
|
0.0203
| - | - | - | - | - |
Year of diagnosis | ||||||||||
2007 | 3 (1.96) | 0.9444 | 0.075 | 11.8891 | 0.9647 | - | - | - | - | - |
2008 | 39 (25.49) | 1.314 | 0.4693 | 3.6789 | 0.6031 | - | - | - | - | - |
2009 | 85 (55.56) | 2.2279 | 0.8935 | 5.5553 | 0.0857 | - | - | - | - | - |
2010 | 26 (16.99) | 1 | - | - | - | - | - | - | - | - |
Delay of treatment | ||||||||||
< 30 days | 99 (64.71) | 1 | - | - | - | - | - | - | - | - |
(30–90] days | 43 (28.1) | 0.8411 | 0.4097 | 1.7271 | 0.6374 | - | - | - | - | - |
> 90 days | 11 (7.19) | 0.8854 | 0.2535 | 3.0921 | 0.8487 | - | - | - | - | - |
Angiographic type of lesion | ||||||||||
Classic | 36 (33.64) | 1.1957 | 0.4961 | 2.8816 | 0.6905 | - | - | - | - | - |
Predominantly classic | 11 (10.28) | 0.3587 | 0.0841 | 1.5291 | 0.1658 | - | - | - | - | - |
Minimally classic | 13 (12.15) | 0.5978 | 0.1694 | 2.1097 | 0.4239 | - | - | - | - | - |
Occult | 45 (42.06) | 1 | - | - | - | - | - | - | - | - |
Others | 2 (1.87) | - | - | - | 0.9879 | - | - | - | - | - |
Status of the fellow eye | ||||||||||
Initial/intermediate AMD | 54 (37.5) | 1 | - | - | - | - | - | - | - | - |
Neovascular | 9 (6.25) | 4.375 | 0.8314 | 23.0235 | 0.1015 | - | - | - | - | - |
Atrophic | 36 (25) | 0.8929 | 0.3806 | 2.0947 | 0.7945 | - | - | - | - | - |
Disciform scar | 30 (20.83) | 1.25 | 0.511 | 3.0579 | 0.6249 | - | - | - | - | - |
Others | 15 (10.42) | 0.625 | 0.1882 | 2.0755 | 0.4428 | - | - | - | - | - |
Status of the lens | ||||||||||
Cataract | 88 (67.18) | 1 | - | - | - | - | - | - | - | - |
Pseudophakia | 40 (30.53) | 1.1679 | 0.5516 | 2.4728 | 0.6851 | - | - | - | - | - |
Transparent | 3 (2.29) | 1.9111 | 0.1671 | 21.8512 | 0.6024 | - | - | - | - | - |
BCVA | 153 | 0.8892 | 0.4752 | 1.6636 | 0.7132 | 153 | 1.0638 | 0.5598 | 2.0217 | 0.8502 |
CMT change | - | - | - | - | - | 150 | 1.4185 | 0.5473 | 3.677 | 0.4718 |
OCT assessment | ||||||||||
SRF | 34 (25) | 1.25 | 0.5603 | 2.7889 | 0.5858 | 45 (30) | 1.4286 | 0.6966 | 2.9297 | 0.3304 |
Thickening | 19 (13.97) | 0.9091 | 0.3309 | 2.4976 | 0.8534 | 7 (4.67) | 1.6667 | 0.3525 | 7.8809 | 0.5193 |
Both | 81 (59.56) | 1 | - | - | - | 8 (5.33) | 0.1786 | 0.0211 | 1.5119 | 0.1139 |
None | 2 (1.47) | 1.25 | 0.0755 | 20.6845 | 0.8762 | 90 (60) | 1 | - | - | - |
Macular associated lesions | ||||||||||
Bleeding >50% | 17 (15.45) | 0.8466 | 0.2729 | 2.6266 | 0.7731 | 4 (4.04) | 0.2857 | 0.0273 | 2.9932 | 0.2959 |
PED | 32 (29.09) | 1.2245 | 0.4837 | 3.1 | 0.6691 | 21 (21.21) | 0.6429 | 0.2207 | 1.8728 | 0.418 |
RPE tear | 2 (1.82) | - | - | - | 0.9922 | 3 (3.03) | 1.7143 | 0.1433 | 20.504 | 0.6703 |
Initial minimal atrophy | 5 (4.55) | 1.4286 | 0.2156 | 9.4665 | 0.7119 | 8 (8.08) | 2.5714 | 0.4606 | 14.355 | 0.2817 |
Initial minimal fibrosis | 10 (9.09) | 0.2381 | 0.045 | 1.2599 | 0.0914 | 23 (23.23) |
0.3025
|
0.0983
|
0.9306
|
0.037
|
RAP | 1 (0.91) | - | - | - | 0.9945 | 1 (1.01) | - | - | - | 0.9914 |
PV | 2 (1.82) | - | - | - | 0.9922 | 0 (0) | - | - | - | - |
Others | 41 (37.27) | 1 | - | - | - | 39 (39.39) | 1 | - | - | - |
Total time of treatment | - | - | - | - | - | - | - | - | - | - |
Number of injections | - | - | - | - | - | 153 |
2.5099
|
1.318
|
4.7796
|
0.0051
|
Number of visits | - | - | - | - | - | 133 | 0.9856 | 0.6336 | 1.5332 | 0.9486 |
1 year | 2 years | |||||||||
n (%) | OR | CI 95% |
p-value | n (%) | OR | CI 95% |
p-value | |||
Age | - | - | - | - | - | - | - | - | - | - |
Sex | ||||||||||
Female | - | - | - | - | - | - | - | - | - | - |
Male | - | - | - | - | - | - | - | - | - | - |
Year of diagnosis | ||||||||||
2007 | - | - | - | - | - | - | - | - | - | - |
2008 | - | - | - | - | - | - | - | - | - | - |
2009 | - | - | - | - | - | - | - | - | - | - |
2010 | - | - | - | - | - | - | - | - | - | - |
Delay of treatment | ||||||||||
< 30 days | - | - | - | - | - | - | - | - | - | - |
(30–90] days | - | - | - | - | - | - | - | - | - | - |
> 90 days | - | - | - | - | - | - | - | - | - | - |
Angiographic type of lesion | ||||||||||
Classic | - | - | - | - | - | - | - | - | - | - |
Predominantly classic | - | - | - | - | - | - | - | - | - | - |
Minimally classic | - | - | - | - | - | - | - | - | - | - |
Occult | - | - | - | - | - | - | - | - | - | - |
Others | - | - | - | - | - | - | - | - | - | - |
Status of the fellow eye | ||||||||||
Initial/intermediate AMD | - | - | - | - | - | - | - | - | - | - |
Neovascular | - | - | - | - | - | - | - | - | - | - |
Atrophic | - | - | - | - | - | - | - | - | - | - |
Disciform scar | - | - | - | - | - | - | - | - | - | - |
Others | - | - | - | - | - | - | - | - | - | - |
Status of the lens | ||||||||||
Cataract | - | - | - | - | - | - | - | - | - | - |
Pseudophakia | - | - | - | - | - | - | - | - | - | - |
Transparent | - | - | - | - | - | - | - | - | - | - |
BCVA | 153 | 0.6119 | 0.3314 | 1.1298 | 0.1164 | 153 |
0.313
|
0.1742
|
0.5623
|
0.0001
|
CMT change | 151 | 1.234 | 0.5158 | 2.9522 | 0.6367 | 151 | 0.5479 | 0.2503 | 1.1994 | 0.1323 |
OCT assessment | ||||||||||
SRF | 43 (29.25) | 0.9004 | 0.4568 | 1.9927 | 0.9004 | 24 (17.02) | 1.0262 | 0.421 | 2.5014 | 0.9547 |
Thickening | 9 (6.12) | 0.4934 | 0.1414 | 2.5674 | 0.4934 | 4 (2.84) | - | - | - | 0.9891 |
Both | 9 (6.12) | 0.2342 | 0.5657 | 10.2697 | 0.2342 | 9 (6.38) | 1.516 | 0.3851 | 5.9677 | 0.5518 |
None | 86 (58.5) | 1 | - | - | - | 104 (73.76) | 1 | - | - | - |
Macular associated lesions | ||||||||||
Bleeding >50% | 1 (0.9) | - | - | - | 0.9944 | 1 (0.88) | - | - | - | 0.9944 |
PED | 16 (14.41) | 0.7143 | 0.2001 | 2.5495 | 0.6042 | 15 (13.16) | 0.4667 | 0.1135 | 1.9195 | 0.2909 |
RPE tear | 3 (2.7) | - | - | - | 0.9907 | 2 (1.75) | - | - | - | 0.9924 |
Initial minimal atrophy | 20 (18.02) | 2.1429 | 0.5856 | 7.8414 | 0.2495 | 26 (22.81) |
5.3667
|
1.1472
|
25.105
|
0.0328
|
Initial minimal fibrosis | 47 (42.34) |
0.1931
|
0.0662
|
0.5632
|
0.0026
| 52 (45.61) |
0.1273
|
0.0374
|
0.4332
|
0.001
|
RAP | 0 (0) | - | - | - | - | 0 (0) | - | - | - | - |
PV | 0 (0) | - | - | - | - | 1 (0.88) | - | - | - | 0.9946 |
Others | 24 (21.62) | 1 | - | - | - | 17 (14.91) | 1 | - | - | - |
Total time of treatment | - | - | - | - | - | - | - | - | - | - |
Number of injections | 153 | 1.1762 | 0.9157 | 1.5107 | 0.2038 | 150 | 1.0851 | 0.8399 | 1.4021 | 0.5319 |
Number of visits | 146 | 1.1098 | 0.9481 | 1.2991 | 0.1949 | 146 | 0.9166 | 0.7719 | 1.0885 | 0.3207 |
3 years | 4 years | |||||||||
n (%) | OR | CI 95% |
p-value | n (%) | OR | CI 95% |
p-value | |||
Age | - | - | - | - | - | - | - | - | - | - |
Sex | ||||||||||
Female | - | - | - | - | - | - | - | - | - | - |
Male | - | - | - | - | - | - | - | - | - | - |
Year of diagnosis | ||||||||||
2007 | - | - | - | - | - | - | - | - | - | - |
2008 | - | - | - | - | - | - | - | - | - | - |
2009 | - | - | - | - | - | - | - | - | - | - |
2010 | - | - | - | - | - | - | - | - | - | - |
Delay of treatment | ||||||||||
< 30 days | - | - | - | - | - | - | - | - | - | - |
(30–90] days | - | - | - | - | - | - | - | - | - | - |
> 90 days | - | - | - | - | - | - | - | - | - | - |
Angiographic type of lesion | ||||||||||
Classic | - | - | - | - | - | - | - | - | - | - |
Predominantly classic | - | - | - | - | - | - | - | - | - | - |
Minimally classic | - | - | - | - | - | - | - | - | - | - |
Occult | - | - | - | - | - | - | - | - | - | - |
Others | - | - | - | - | - | - | - | - | - | - |
Status of the fellow eye | ||||||||||
Initial/intermediate AMD | - | - | - | - | - | 30 (20.83) | 1 | - | - | - |
Neovascular | - | - | - | - | - | 20 (13.89) | 0.6667 | 0.212 | 2.0963 | 0.4879 |
Atrophic | - | - | - | - | - | 46 (31.94) | 0.84 | 0.3343 | 2.1105 | 0.7107 |
Disciform scar | - | - | - | - | - | 35 (24.31) | 1.0588 | 0.3992 | 2.8085 | 0.9086 |
Others | - | - | - | - | - | 13 (9.03) | 0.4444 | 0.112 | 1.7634 | 0.2488 |
Status of the lens | ||||||||||
Cataract | - | - | - | - | - | - | - | - | - | - |
Pseudophakia | - | - | - | - | - | - | - | - | - | - |
Transparent | - | - | - | - | - | - | - | - | - | - |
BCVA | 153 |
0.2781
|
0.1539
|
0.5026
|
<0.0001
| 153 |
0.3332
|
0.1982
|
0.56
|
<0.0001
|
CMT change | 151 |
0.4459
|
0.2122
|
0.937
|
0.003
| 151 |
0.4485
|
0.226
|
0.8901
|
0.0219
|
OCT assessment | ||||||||||
SRF | 15 (15) | 1.1722 | 0.3878 | 3.543 | 0.7784 | 5 (10) | 2.8 | 0.4205 | 18.644 | 0.2871 |
Thickening | 4 (4) | 0.3419 | 0.0341 | 3.4296 | 0.3616 | 0 (0) | - | - | - | - |
Both | 2 (2) | - | - | - | 0.988 | 2 (4) | - | - | - | - |
None | 79 (79) | 1 | - | - | - | 43 (86) | 1 | - | - | - |
Macular associated lesions | ||||||||||
Bleeding >50% | 0 (0) | - | - | - | - | 0 (0) | - | - | - | - |
PED | 8 (8.89) | 0.5 | 0.065 | 3.8453 | 0.5054 | 1 (2.13) | - | - | - | 0.9947 |
RPE tear | 3 (3.33) | - | - | - | 0.9902 | 1 (2.13) | - | - | - | 0.9943 |
Initial minimal atrophy | 26 (28.89) |
6.3
|
1.2752
|
31.1244
|
0.0239
| 12 (25.53) | 6 | 0.3901 | 92.277 | 0.1988 |
Initial minimal fibrosis | 43 (47.78) | 0.3971 | 0.0919 | 1.7149 | 0.2159 | 30 (63.83) | 0.4 | 0.0301 | 5.3073 | 0.4873 |
RAP | 0 (0) | - | - | - | - | 0 (0) | - | - | - | - |
PV | 0 (0) | - | - | - | - | 0 (0) | - | - | - | - |
Others | 10 (11.11) | 1 | - | - | - | 3 (6.38) | 1 | - | - | - |
Total time of treatment | - | - | - | - | - | 153 | 0.9844 | 0.9557 | 1.014 | 0.2991 |
Number of injections | 114 |
1.4048
|
1.081
|
1.8254
|
0.011
| 55 |
1.3943
|
1.01
|
1.9249
|
0.0434
|
Number of visits | 114 | 0.9166 | 0.7719 | 1.0885 | 0.3207 | 58 | 1.1477 | 0.9012 | 1.4617 | 0.2642 |