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23.01.2019 | Original Article

Predictive value of FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas: a retrospective study

verfasst von: Mathias Fiedler, Patty Renner, Jürgen Schubert, Florian Weber, Arndt Hartmann, Heinrich Iro, Veronika Vielsmeier, Christopher Bohr, Michael Gerken, Torsten E. Reichert, Tobias Ettl

Erschienen in: Clinical Oral Investigations | Ausgabe 10/2019

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Abstract

Objectives

The aim of this study was to investigate the predictive value of the biomarkers FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas.

Material and methods

Immunohistochemical staining of FHIT, p27, and pERK1/ERK2 of 265 patients with salivary gland carcinomas was conducted, and associations with clinico-histopathological data, overall survival, and disease-specific survival were examined.

Results

Expression of FHIT (quick score 98.7 vs. 206.4) and p27 (QS 187.3 vs. 244.8) was significantly lower in carcinomas compared to non-tumor control tissue. Loss of FHIT frequently occurred in ACC (55.2%), SDC (68.2%), and SCC (100%). In the totality of tumors, loss of FHIT expression was found in 46.7% (106/227) and was significantly associated with advanced T stage and UICC stage, high-grade histology, loss of p27, PI3K, and survivin. FHIT positivity went along with significantly better overall and disease-specific survival. Negativity of p27 occurred in 28.7% (70/244) of tumors, particularly in SDC (54.4%) and SCC (50%). In the totality of tumors, p27 was associated with advanced patient age, high-grade histology, PI3K, survivin as well as better overall and disease-specific survival (p < 0.05). Positive pERK1/ERK2 expression correlated with positive survivin expression but did not affect overall survival in the totality of tumors. In mucoepidermoid carcinomas, pERK1/ERK2 expression was associated with low-grade malignancy, positive nuclear survivin, and better disease-specific survival.

Conclusions

Loss of FHIT and p27 characterizes aggressive tumor growth and unfavorable prognosis in salivary gland cancer.

Clinical relevance

The results may help to stratify patient-specific therapies according to individual tumor characteristics.

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Titel: Predictive value of FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas: a retrospective study
verfasst von: Mathias Fiedler
Patty Renner
Jürgen Schubert
Florian Weber
Arndt Hartmann
Heinrich Iro
Veronika Vielsmeier
Christopher Bohr
Michael Gerken
Torsten E. Reichert
Tobias Ettl
Publikationsdatum: 23.01.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 10/2019
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-019-02809-z

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Predictive value of FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas: a retrospective study

Abstract

Objectives

Material and methods

Results

Conclusions

Clinical relevance

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Abstract

Objectives

Material and methods

Results

Conclusions

Clinical relevance

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