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Erschienen in:
22.05.2019 | Original Article
Predictive value of the ratio of homocysteine to serum albumin concentrations in the recurrence of diabetic foot ulcer
Erschienen in: International Journal of Diabetes in Developing Countries | Ausgabe 4/2019
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Objective
To investigate the predictive value of the ratio of homocysteine to serum albumin concentrations (Hcy/Alb) in the recurrence of diabetic foot ulcer (DFU).
Methods
A total of 210 patients hospitalized due to diabetic foot disease from May 2012, to May 2017 were selected and followed up for one year. The value of Hcy/Alb in predicting the recurrence of DFU was determined using receiver operating characteristic (ROC) curve analysis.
Results
Hcy (odd ratio = 1.171; 95% confidence interval (CI) 1.101–1.246) was an independent risk factor for the recurrence of DFU. Alb (odd ratio = 0.848; 95% CI 0.792–0.908) was a protective factor for the recurrence of DFU. The area under the ROC curve of Hcy/Alb for predicting the recurrence of DFU was 0.803 (95% CI 0.742–0.864; p < 0.01). When the Hcy/Alb was set at the best cutoff value (0.37), its sensitivity in predicting the recurrence of DFU was 97.60%, and the negative predictive value was 98.93%.
Conclusions
The sensitivity and negative predictive value of Hcy/Alb in predicting the recurrence of DFU and the overall coincidence rate are high.