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12.11.2016

Predictors of fatigue and poor sleep in adult survivors of childhood Hodgkin’s lymphoma: a report from the Childhood Cancer Survivor Study

verfasst von: Amanda M. Rach, Valerie McLaughlin Crabtree, Tara M. Brinkman, Lonnie Zeltzer, Jordan Gilleland Marchak, Deokumar Srivastava, Brooklee Tynes, Jin-Shei Lai, Leslie L. Robison, Gregory T. Armstrong, Kevin R. Krull

Erschienen in: Journal of Cancer Survivorship | Ausgabe 2/2017

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Abstract

Purpose

Survivors of pediatric Hodgkin’s lymphoma (HL) are at risk for a number of debilitating late effects. Excessive fatigue and poor sleep quality are primary complaints of HL survivors. Understanding the emotional and physical factors that influence fatigue and sleep quality may provide opportunities for intervention to improve health-related quality of life for HL survivors.

Methods

Data from 751 adult survivors of childhood HL who participated in the Childhood Cancer Survivor Study (CCSS) from 2000–2002 were analyzed. Multivariable logistic regression analyses investigated the demographic, psychological, and physical variables that predicted clinically significant levels of poor sleep quality, fatigue, and excessive daytime sleepiness.

Results

Survivors’ self-reported level of emotional distress, pain, and physical functioning limitations did not differ from population norms. Clinically elevated levels of emotional distress (OR 8.38, 95% CI 4.28–16.42) and pain (OR 3.73, 95% CI 2.09–6.67) increased the risk for endorsing elevated levels of fatigue. Survivors with elevated levels of emotional distress (OR 6.83, 95% CI 2.71–15.90) and pain (OR 5.27, 95% CI 1.78–15.61) were more likely to report poor sleep quality. Pain (OR 2.11, 95% CI 1.39–3.34) was related to excessive daytime sleepiness.

Conclusions

Emotional and physical factors are associated with elevated levels of fatigue, excessive daytime sleepiness, and poor sleep quality in survivors of pediatric HL. This is consistent with findings from research conducted with non-cancer survivors.

Implications for cancer survivors

These results suggest that interventions designed to target sleep and fatigue difficulties in the general population may be well suited for pediatric HL survivors as well.

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Titel: Predictors of fatigue and poor sleep in adult survivors of childhood Hodgkin’s lymphoma: a report from the Childhood Cancer Survivor Study
verfasst von: Amanda M. Rach
Valerie McLaughlin Crabtree
Tara M. Brinkman
Lonnie Zeltzer
Jordan Gilleland Marchak
Deokumar Srivastava
Brooklee Tynes
Jin-Shei Lai
Leslie L. Robison
Gregory T. Armstrong
Kevin R. Krull
Publikationsdatum: 12.11.2016
Verlag: Springer US
Erschienen in: Journal of Cancer Survivorship / Ausgabe 2/2017
Print ISSN: 1932-2259
Elektronische ISSN: 1932-2267
DOI: https://doi.org/10.1007/s11764-016-0583-y

Springer Medizin

Predictors of fatigue and poor sleep in adult survivors of childhood Hodgkin’s lymphoma: a report from the Childhood Cancer Survivor Study