Background
Methods
Patients
Clinical and laboratory data collection
Definition of prognostic nutritional index and cutoff values
Statistical analysis
Results
Baseline of patients’ characteristics
Patient-related factors | No. of patients (%) | OS (months) [mean (95 % CI)] |
P values |
---|---|---|---|
Gender | |||
Male | 80 (79.2) | 42.3 (36.9–47.7) | 0.343 |
Female | 21 (20.8) | 48.5 (39.4–57.7) | |
Age (years) | |||
<60 | 23 (22.8) | 44.5 (34.9–54.1) | 0.976 |
≥60 | 78 (77.2) | 43.3 (38.9–48.3) | |
BMI (kg/m2) | |||
<18.5 | 9 (8.9) | 31.7 (18.8–14.6) | 0.180 |
≥18.5 and <25 | 71 (70.3) | 45.5 (40.0–51.1) | |
≥25 | 21 (20.8) | 41.4 (30.7–52.0) | |
Hemoglobin (g/L) | |||
<120 | 41 (40.6) | 38.4 (31.4–45.4) | 0.029* |
≥120 | 60 (59.4) | 44.6 (41.0–53.4) | |
Albumin (g/L) | |||
<40 | 27 (26.7) | 35.7 (26.4–44.9) | 0.036* |
≥40 | 74 (73.3) | 46.0 (38.9–48.3) | |
Pre-albumin (g/L) | |||
<200 | 29 (28.7) | 31.5 (23.6–39.3) | <0.001* |
≥200 | 72 (71.3) | 48.0 (43.0–53.8) | |
PNI | |||
<51 | 54 (53.5) | 37.6 (31.0–44.2) | 0.008* |
≥51 | 47 (46.5) | 50.5 (44.3–56.7) | |
Tumor size (cm) | 0.004* | ||
<5 | 64 (63.4) | 48.3 (42.5–54.1) | |
≥5 | 37 (36.6) | 35.4 (28.0–42.8) | |
Differentiation grade | |||
Poor | 69 (68.3) | 39.4 (33.5–45.3) | 0.031* |
Well | 32 (31.7) | 52.0 (45.0–58.0) | |
Tumor location | |||
Siewert II | 6 (5.9) | 40.3 (19.6–61.1) | 0.923 |
Siewert III | 95 (5.1) | 43.8 (38.9–48.6) | |
T stage | |||
T1, T2 | 18 (17.8) | 61.9 (56.2–67.6) | 0.001* |
T3, T4 | 83 (82.2) | 39.6 (34.4–44.9) | |
N stage | |||
N0 | 41 (40.6) | 51.1 (43.9–58.4) | 0.001* |
N1 | 43 (42.6) | 41.3 (34.7–47.9) | |
N2 | 16 (15.8) | 32.5 (20.8–44.2) | |
N3 | 1 (1.0) | 8.0 (8.0–8.0) | |
TNM stage | |||
I, II | 44 (43.6) | 52.5 (45.7–59.2) | <0.001* |
III, IV | 57 (56.4) | 36.7 (30.8–42.7) | |
Surgical type | |||
Total gastrectomy | 6 (5.9) | 57.0 (42.7–71.3) | 0.131 |
Proximal gastrectomy | 95 (94.1) | 42.7 (37.8–47.6) |
Univariate analysis of prognostic factors
Multivariate analysis of prognostic factors
Patient-related factors | Hazard ratio | 95 % CI |
P value |
---|---|---|---|
Albumin (g/L) | |||
<40 | 1 | 0.874 | |
≥40 | 0.945 | 0.469–1.903 | |
Hemoglobin (g/L) | |||
<120 | 1 | 1.000 | |
≥120 | 1.000 | 0.527–1.899 | |
PNI | |||
<51 | 1 | 0.426 | |
≥51 | 0.751 | 0.372–1.518 | |
Pre-albumin (g/L) | |||
<200 | 1 | 0.021* | |
≥200 | 0.494 | 0.271–0.901 | |
Tumor size (cm) | |||
<5 | 1 | 0.869 | |
≥5 | 1.053 | 0.567–1.957 | |
TNM stage | |||
I, II | 1 | 0.013* | |
III, IV | 2.530 | 1.220–5.248 | |
Differentiation grade | |||
Poor | 1 | 0.248 | |
Well | 1.335 | 0.307–1.357 |
Definition of prognostic factors
Relationship between the pre-albumin and clinicopathologic characteristics
Patient-related factors | Pre-albumin <200 mg/L | Pre-albumin ≥200 mg/L |
P value |
---|---|---|---|
(n = 29) | (n = 72) | ||
Gender | 0.260 | ||
Male | 22 | 58 | |
Female | 7 | 14 | |
Age (years) | 0.565 | ||
<60 | 4 | 19 | |
≥60 | 25 | 53 | |
BMI (kg/m2) | 0.084 | ||
<18.5 | 7 | 2 | |
18.5 ≤ < 23 | 13 | 38 | |
23≤ | 9 | 32 | |
Hemoglobin (g/L) | 0.014* | ||
<120 | 17 | 24 | |
≥120 | 12 | 48 | |
Albumin (g/L) | 0.052 | ||
<40 | 14 | 13 | |
≥40 | 15 | 59 | |
PNI | 0.011* | ||
<51 | 20 | 34 | |
≥51 | 9 | 38 | |
Differentiation grade | 0.044* | ||
Poor | 20 | 49 | |
Well | 9 | 23 | |
Tumor location | 0.632 | ||
Siewert II | 1 | 5 | |
Siewert III | 28 | 67 | |
Tumor size (cm) | 0.004* | ||
<5 | 14 | 50 | |
≥5 | 15 | 22 | |
TNM stage | <0.001* | ||
I, II | 10 | 34 | |
III, IV | 19 | 38 |