Background
Methods
Study subjects
Groups | Number of cases | Age | Disease duration | Age at onset |
---|---|---|---|---|
(females/males) | (mean ± SD, range) | (mean ± SD, range) | (mean ± SD, range) | |
All cases | 312 (253/59) | 58.0 ± 12.7, 23-90 | 10.0 ± 8.8, 1-50 | 48.0 ± 13.1, 10-80 |
Good responders | 179 (143/36) | 59.4 ± 12.4, 23-84 | 9.0. ± 7.3, 1-37 | 50.4 ± 12.3, 19-77 |
Poor responders | 133 (110/23) | 56.1 ± 12.9, 24-90 | 11.3 ± 10.0, 1-50 | 44.9 ± 13.5, 10-80 |
DNA isolation, KIR and KIR ligand typing
Statistical analysis
Results
MTX response |
KIR genes | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
2DS2
|
2DL3
|
2DL2
|
2DS3
|
2DL1
|
3DL1
|
3DS1
|
2DS5
|
2DS1
|
2DS4f*
|
2DS4d
| |
Good responders (N = 179) | |||||||||||
Presence (N) | 107 | 155 | 103 | 68 | 178 | 171 | 59 | 52 | 71 | 55 | 156 |
Absence (N) | 7 | 24 | 76 | 111 | 21 | 8 | 120 | 127 | 108 | 124 | 23 |
Frequency [%] | 59.78 | 86.59 | 57.54 | 37.99 | 99.44 | 95.53 | 32.96 | 29.05 | 39.66 | 30.73 | 87.15 |
Poor responders (N = 133) | |||||||||||
Presence (N) | 75 | 121 | 71 | 33 | 129 | 121 | 46 | 41 | 55 | 50 | 110 |
Absence (N) | 5 | 12 | 62 | 100 | 84 | 12 | 87 | 92 | 78 | 83 | 23 |
Frequency [%] | 56.39 | 90.98 | 53.38 | 24.81 | 96.99 | 90.98 | 34.59 | 30.83 | 41.35 | 37.59 | 82.71 |
MTX responsiveness | Frequency (good responders/all) | ||
---|---|---|---|
ED | RF |
2DS4f presence |
2DS4f absence |
+ | + | 36.2 (21/58) | 43.6 (48/110) |
+ | - | 70.0 (14/20) | 76.7 (33/43) |
- | + | 72.7 (8/11) | 72.4 (21/29) |
- | - | 75.0 (12/16) | 88.0 (22/25) |