Background
Methods
Setting and study population
Sampling method
Data collection
Definition
Statistical analysis
Ethics approval
Results
General characteristics
General characteristic | n | % |
---|---|---|
Total | 831 |
100.0
|
Sex | ||
Male | 549 |
66.1
|
Female | 282 |
33.9
|
Age in years | ||
15–24 | 92 |
11.1
|
25–34 | 133 |
16.0
|
35–44 | 142 |
17.1
|
45–54 | 137 |
16.5
|
55–64 | 175 |
21.1
|
65 years and older | 152 |
18.3
|
Mean age (SD) | 48.4 (18.2) | |
Education | ||
Primary and lower | 143 |
17.2
|
Secondary; high school | 531 |
63.9
|
Colleagues/University or higher | 157 |
18.9
|
Occupation | ||
Unemployed | 113 |
13.6
|
Farmer | 259 |
31.2
|
Self-employed
| 49 |
5.9
|
Government employed/ Student; pupil / retired
| 410 |
49.3
|
Marital status | ||
Single | 158 |
19.0
|
Married | 629 |
75.7
|
Divorced / separated | 44 |
5.3
|
Residence | ||
Rural | 430 |
51.7
|
Urban | 401 |
48.3
|
Monthly Income (VND) | ||
< 3,000,000 (~ 132.3 US$) | 468 |
56.3
|
3,000,000 - 5,000,000 (~ 132.3–220.5 US$) | 220 |
26.5
|
> 5,000,000 (~ 220.5 US$) | 143 |
17.2
|
Socio-economic status | ||
Poor/ near-poor household | 103 |
12.4
|
Medium household and above | 728 |
87.6
|
BMI, kg/m2 | ||
Underweight, < 18.5 | 289 |
34.8
|
Normal, 18.5–24.9 | 518 |
62.3
|
Overweight, > = 25 | 24 |
2.9
|
Mean (SD) | 19.6 (3.0) |
Prevalence of prediabetes and DM among TB patients
Total TB patients evaluated for DM (n) | TB patients with pre-DM (n) | Prevalence of pre-DM (%; 95% CI) | p value* | TB patients with DM (n) | Prevalence of DM (%; 95% CI) | p value* | |
---|---|---|---|---|---|---|---|
Total |
831
|
241
|
29.0 (25.9–32.1)
|
114
|
13.7 (11.4–16.1)
| ||
Sex | 0.274 | 0.007 | |||||
Male | 549 | 166 | 30.2 (26.4–34.1) | 88 | 16.0 (13.0–19.1) | ||
Female | 282 | 75 | 26.6 (21.4–31.8) | 26 | 9.2 (5.8–12.6) | ||
Age, years |
< 0.001
|
< 0.001
| |||||
15–24 | 92 | 19 | 20.7 (12.2–29.1) | 5 | 5.4 (0.7–10.1) | ||
25–34 | 133 | 23 | 17.3 (10.8–23.8) | 6 | 4.5 (0.9–8.1) | ||
35–44 | 142 | 37 | 26.1 (18.7–33.4) | 16 | 11.3 (6.0–16.5) | ||
45–54 | 137 | 47 | 34.3 (26.3–42.4) | 27 | 19.7 (13.0–26.5) | ||
55–64 | 175 | 61 | 34.9 (27.7–42.0) | 33 | 18.9 (13.0–24.7) | ||
≥ 65 | 152 | 54 | 35.5 (27.8–43.2) | 27 | 17.8 (11.6–23.9) | ||
Education |
0.002
| 0.624 | |||||
Primary or lower | 143 | 49 | 34.3 (26.4–42.1) | 19 | 13.3 (7.7–18.9) | ||
Secondary; high school | 531 | 163 | 30.7 (26.8–34.6) | 77 | 14.5 (11.5–17.5) | ||
Colleagues/University or higher | 157 | 29 | 18.5 (12.3–24.6) | 18 | 11.5 (6.4–16.5) | ||
Occupation |
0.002
| 0.328 | |||||
Unemployed | 113 | 35 | 31.0 (22.3–39.6) | 15 | 13.3 (6.9–19.6) | ||
Farmer | 259 | 96 | 37.1 (31.1–43.0) | 28 | 10.8 (7.0–14.6) | ||
Self-employed | 49 | 15 | 30.6 (17.2–44.0) | 9 | 18.4 (7.1–29.6) | ||
Government employed/ Student; pupil / retired | 410 | 95 | 23.2 (19.1–27.3) | 62 | 15.1 (11.6–18.6) | ||
Marital status | 0.062 | 0.481 | |||||
Single | 158 | 34 | 21.5 (15.0–28.0) | 17 | 10.8 (5.9–15.6) | ||
Married | 629 | 192 | 30.5 (26.9–34.1) | 91 | 14.5 (11.7–17.2) | ||
Divorced/separated | 44 | 15 | 34.1 (19.5–48.7) | 6 | 13.6 (3.1–24.2) | ||
Residence | 0.084 | 0.107 | |||||
Rural | 430 | 136 | 31.6 (27.2–36.0) | 51 | 11.9 (8.8–14.9) | ||
Urban | 401 | 105 | 26.2 (21.9–30.5) | 63 | 15.7 (12.1–19.3) | ||
Monthly income (VND) |
< 0.001
| 0.636 | |||||
< 3,000,000 (~ 132.3 US$) | 468 | 153 | 32.7 (28.4–37.0) | 60 | 12.8 (9.8–15.9) | ||
3,000,000 - 5,000,000 (~ 132.3–220.5 US$) | 220 | 65 | 29.5 (23.5–35.6) | 35 | 15.9 (11.0–20.8) | ||
> 5,000,000 (~ 220.5 US$) | 143 | 23 | 16.1 (10.0–22.2) | 19 | 13.3 (7.7–18.9) | ||
Socio-economic status | 0.794 | 0.790 | |||||
Poor/ near-poor household | 103 | 31 | 30.1 (21.1–39.1) | 15 | 14.6 (7.6–21.5) | ||
Medium household and above | 728 | 210 | 28.8 (25.5–32.1) | 99 | 13.6 (11.1–16.1) | ||
BMI, kg/m2 | 0.077 | 0.304 | |||||
Underweight, < 18.5 | 289 | 94 | 32.5 (27.1–38.0) | 38 | 13.1 (9.2–17.1) | ||
Normal, 18.5–24.9 | 518 | 142 | 27.4 (23.6–31.3) | 69 | 13.3 (10.4–16.3) | ||
Overweight, > = 25 | 24 | 5 | 20.8 (3.3–38.4) | 7 | 29.2 (9.6–48.8) |
Lifestyle factors
Total TB patients evaluated for DM (n) | TB patients with pre-DM (n) | Prevalence of pre-DM (%; 95% CI) | p value | TB patients with DM (n) | Prevalence of DM (%; 95% CI) | p value | |
---|---|---|---|---|---|---|---|
Total | 831 | 241 | 29.0 (25.9–32.1) | 114 | 13.7 (11.4–16.1) | ||
Family history of DM | 0.052 |
< 0.001
| |||||
Yes | 69 | 13 | 18.8 (9.4–28.3) | 20 | 29.0 (18.0–40.0) | ||
No | 762 | 228 | 29.9 (26.7–33.2) | 94 | 12.4 (10.0–14.7) | ||
Physical activities | 0.283 | 0.299 | |||||
Yes | 278 | 74 | 26.6 (21.4–31.8) | 43 | 15.5 (11.2–19.7) | ||
No | 553 | 167 | 30.2 (26.4–34.0) | 71 | 12.8 (10.0–15.6) | ||
Frequently of physical activities | 0.426 | 0.147 | |||||
> 4 times per week | 168 | 47 | 28.0 (21.1–34.8) | 30 | 17.9 (12.0–23.7) | ||
1–4 times per week | 63 | 16 | 25.4 (14.3–36.4) | 9 | 14.3 (5.4–23.1) | ||
1–3 times per month | 30 | 8 | 26.7 (9.9–43.5) | 2 | 6.7 (0–16.1) | ||
< 1 time per month | 17 | 3 | 17.6 (0.0–37.9) | 2 | 11.8 (0–28.8) | ||
Smoker |
0.036
| 0.116 | |||||
Never smoker | 510 | 134 | 26.3 (22.4–30.1) | 61 | 12.0 (9.1–14.8) | ||
Ex-smoker | 213 | 70 | 32.9 (26.5–39.2) | 36 | 16.9 (11.8–22.0) | ||
Smoker | 108 | 37 | 34.3 (25.2–43.4) | 17 | 15.7 (8.8–22.7) | ||
Drinker | 0.705 | 0.454 | |||||
Drinker | 374 | 106 | 28.3 (23.8–32.9) | 55 | 14.7 (11.1–18.3) | ||
Non-drinker | 457 | 135 | 29.5 (25.3–33.7) | 59 | 12.9 (9.8–16.0) | ||
Type of TB | 0.219 | 0.070 | |||||
PTB - smear positive | 391 | 122 | 31.2 (26.6–35.8) | 60 | 15.3 (11.8–18.9) | ||
PTB - smear negative | 271 | 68 | 25.1 (19.9–30.3) | 40 | 14.8 (10.5–19.0) | ||
EPTB | 169 | 51 | 30.2 (23.2–37.2) | 14 | 8.3 (4.1–12.5) | ||
TB treatment category | 0.138 | 0.815 | |||||
New | 713 | 200 | 28.1 (24.7–31.4) | 97 | 13.6 (11.1–16.1) | ||
Previously treated | 118 | 41 | 34.7 (26.0–43.5) | 17 | 14.4 (8.0–20.8) | ||
HIV status | 0.722 | 0.555 | |||||
Positive | 16 | 4 | 25.0 (1.2–48.8) | 3 | 18.8 (10.1–40.2) | ||
Negative | 815 | 237 | 29.1 (1.6–26.0) | 111 | 13.6 (11.3–16.0) |
Risk factors associated with DM
Characteristics | OR (95% CI) | p value | aOR (95% CI)* | p value |
---|---|---|---|---|
Age (years) | ||||
< 40 | Reference | |||
40–64 | 3.56 (2.08–6.07) | < 0.001 | 6.09 (2.81–13.2) | < 0.001 |
≥ 65 | 3.42 (1.88–6.23) | < 0.001 | 2.65 (1.65–4.25) | < 0.001 |
Sex | ||||
Female | Reference | |||
Male | 1.74 (1.15–2.63) | 0.007 | 1.62 (0.96–2.75) | 0.071 |
Family history of DM | ||||
No | Reference | |||
Yes | 2.35 (1.55–3.56) | < 0.001 | 2.71 (1.33–5.50) | 0.006 |
Type of TB | ||||
Extra-pulmonary | Reference | |||
Smear negative | 1.78 (1.00–3.17) | 0.044 | 1.26 (0.83–1.91) | 0.272 |
Smear positive | 1.85 (1.07–3.22) | 0.024 | 1.83 (0.86–3.93) | 0.119 |
Smoker | ||||
Never smoke | Reference | |||
Current smoker | 1.32 (0.80–2.16) | 0.283 | 0.75 (0.33–1.71) | 0.494 |
Ex-smoker | 1.41 (0.97–2.07) | 0.076 | 0.58 (0.31–1.10) | 0.094 |
BMI | ||||
< 18.5 | Reference | |||
18.5–24.9 | 1.01 (0.70–1.46) | 0.945 | 1.03 (0.65–1.64) | 0.885 |
> =25 | 2.22 (1.11–4.42) | 0.032 | 2.27 (0.75–6.82) | 0.146 |
Education | ||||
Primary or lower | Reference | |||
Secondary; high school | 1.09 (0.68–1.74) | 0.712 | 1.07 (0.55–2.05) | 0.850 |
Colleagues/University or higher | 0.86 (0.47–1.58) | 0.632 | 0.47 (0.12–1.84) | 0.281 |
Additional yield of DM
Characteristic | Total TB patients evaluated for DM (n) | Number of patients with previous DM (n) | Number of newly diagnosed DM patients (n) | Additional yield (%) | Number needed to screen to diagnose a new case (n) |
---|---|---|---|---|---|
Total | 831 | 64 | 50 | 43.9 | 17 |
Sex | |||||
Male | 549 | 49 | 39 | 44.3 | 14 |
Female | 282 | 15 | 11 | 42.3 | 26 |
Age, years | |||||
< 40 | 289 | 4 | 11 | 73.3 | 26 |
40–65 | 390 | 45 | 27 | 37.5 | 14 |
≥ 65 | 152 | 15 | 12 | 44.4 | 13 |
Family history of DM | |||||
Yes | 69 | 17 | 3 | 15.0 | 23 |
No | 762 | 47 | 47 | 50.0 | 16 |
Type of TB | |||||
PTB - smear positive | 391 | 40 | 20 | 33.3 | 20 |
PTB - smear negative | 271 | 21 | 19 | 47.5 | 14 |
EPTB | 169 | 3 | 11 | 78.6 | 15 |
BMI, kg/m2 | |||||
Underweight, < 18.5 | 289 | 19 | 19 | 50.0 | 15 |
Normal, 18.5–24.9 | 518 | 38 | 31 | 44.9 | 17 |
Overweight, > = 25 | 24 | 7 | 0 | 0.0 |