Erschienen in:
17.01.2022 | Original Article
Prevalence and clinical significance of serum sodium variability in patients with acute-on-chronic liver diseases: a prospective multicenter study in China
verfasst von:
Xue Mei, Hai Li, Guohong Deng, Xianbo Wang, Xin Zheng, Yan Huang, Jinjun Chen, Zhongji Meng, Yanhang Gao, Feng Liu, Xiaobo Lu, Yu Shi, Yubao Zheng, Huadong Yan, Weituo Zhang, Liang Qiao, Wenyi Gu, Yan Zhang, Xiaomei Xiang, Yi Zhou, Shuning Sun, Yixin Hou, Qun Zhang, Yan Xiong, Congcong Zou, Jun Chen, Zebing Huang, Beiling Li, Xiuhua Jiang, Guotao Zhong, Haiyu Wang, Yuanyuan Chen, Sen Luo, Na Gao, Chunyan Liu, Jing Li, Tao Li, Rongjiong Zheng, Xinyi Zhou, Haotang Ren, Wei Yuan, Zhiping Qian
Erschienen in:
Hepatology International
|
Ausgabe 1/2022
Einloggen, um Zugang zu erhalten
Abstract
Background
No reports exist regarding the prevalence of different Na levels and their relationship with 90-day prognosis in hospitalized patients with acute-on-chronic liver disease (AoCLD) in China. Therefore, the benefit of hyponatremia correction in AoCLD patients remains unclear.
Methods
We prospectively collected the data of 3970 patients with AoCLD from the CATCH-LIFE cohort in China. The prevalence of different Na levels (≤ 120; 120–135; 135–145; > 145) and their relationship with 90-day prognosis were analyzed. For hyponatremic patients, we measured Na levels on days 4 and 7 and compared their characteristics, based on whether hyponatremia was corrected.
Results
A total of 3880 patients were involved; 712 of those developed adverse outcomes within 90 days. There were 80 (2.06%) hypernatremic, 28 (0.72%) severe hyponatremic, and 813 (20.95%) mild hyponatremic patients at admission. After adjusting for all confounding factors, the risk of 90-day adverse outcomes decreased by 5% (odds ratio [OR] 0.95; 95% confidence interval [CI] 0.93–0.97; p < 0.001), 24% (OR 0.76; 95% CI 0.70–0.84; p < 0.001), and 42% (OR 0.58; 95% CI 0.49–0.70; p < 0.001) as Na level increased by 1, 5, and 10 mmol/L, respectively. Noncorrection of hyponatremia on days 4 and 7 was associated with 2.05-fold (hazard ratio [HR], 2.05; 95% CI, 1.50–2.79; p < 0.001) and 1.46-fold (HR 1.46; 95% CI 1.05–2.02; p = 0.028) higher risk of adverse outcomes.
Conclusions
Hyponatremia was an independent risk factor for a poor 90-day prognosis in patients with AoCLD. Failure to correct hyponatremia in a week after admission was often associated with increased mortality. (ClinicalTrials.gov number: NCT02457637, NCT03641872).