Background
Materials and methods
Study design and participants
Setting
Variables and data collection
Study endpoints
Statistical analyses
Results
Prevalence of and independent risk factors for CIN
No CIN | CIN | p value | |
---|---|---|---|
n = 243 (86%) | n = 41 (14%) | ||
Age (years) | 46 ± 22 | 55 ± 23 | 0.019 |
Gender (male) | 192 (79%) | 29 (71%) | 0.238 |
Comorbidities | 145 (60%) | 25 (61%) | 0.875 |
Blunt trauma | 235 (97%) | 40 (98%) | 0.673 |
Injury Severity Score | 28 ± 17 | 30 ± 16 | 0.296 |
AIS head | 3.1 ± 1.8 | 3.2 ± 1.8 | 0.733 |
AIS face | 0.7 ± 1.1 | 0.6 ± 1.2 | 0.765 |
AIS chest | 1.5 ± 1.8 | 1.6 ± 1.7 | 0.771 |
AIS abdomen | 0.6 ± 1.2 | 0.7 ± 1.3 | 0.719 |
AIS extremity | 1.2 ± 1.4 | 1.5 ± 1.6 | 0.316 |
AIS integument | 0.9 ± 0.9 | 0.9 ± 0.8 | 0.961 |
Heart rate at admission (bpm) | 88 ± 24 | 86 ± 22 | 0.513 |
Systolic blood pressure at admission (mmHg) | 121 ± 28 | 112 ± 21 | 0.094 |
Serum creatinine (µmol/l) | 81 ± 29 | 73 ± 26 | 0.026 |
Hemoglobin (g/l) | 11.7 ± 2.4 | 10.4 ± 2.7 | 0.002 |
Fibrinogen (g/l) | 2.1 ± 0.7 | 2.2 ± 1.1 | 0.645 |
Lactate level (mmol/l) | 2.7 ± 2.6 | 2.0 ± 1.7 | 0.036 |
Base excess (mmol/l) | − 4.2 ± 4.6 | − 4.2 ± 4.5 | 0.800 |
Crystalloid (l) | 2.2 ± 2.9 | 2.6 ± 2.4 | 0.042 |
Red blood cells (n) | 1.3 ± 4.9 | 2.3 ± 4.7 | 0.017 |
Fresh frozen plasma | 13 (5.4%) | 4 (9.8%) | 0.287 |
Platelets | 18 (7.5%) | 7(17%) | 0.069 |
Fibrinogen | 80 (33%) | 21 (51%) | 0.027 |
Hemodialysis | 8 (3.3%) | 6 (15%) | 0.008 |
Complications | 136 (56%) | 29 (71%) | 0.076 |
Length of stay (days) | 14 ± 13 | 18 ± 20 | 0.407 |
Mortality | 55 (23%) | 13 (32%) | 0.208 |
OR | 95% CI | p value | ||
---|---|---|---|---|
Age (years) | 1.017 | 1.001 | 1.033 | 0.035 |
Injury Severity Score | 1.008 | 0.988 | 1.029 | 0.430 |
Gender (Male) | 0.806 | 0.370 | 1.760 | 0.589 |
Lactate level (logarithmic) | 0.269 | 0.080 | 0.906 | 0.034 |
Hemodialysis
Complications
OR | 95% CI | p value | ||
---|---|---|---|---|
CIN | 2.029 | 0.960 | 4.291 | 0.064 |
Lactate level (logarithmic) | 2.027 | 0.867 | 4.737 | 0.103 |
Injury Severity Score | 1.025 | 1.008 | 1.042 | 0.004 |
Age (years) | 0.998 | 0.986 | 1.010 | 0.730 |
Gender (male) | 0.939 | 0.511 | 1.727 | 0.840 |
Length of hospital stay
Mortality
OR | 95% CI | p value | ||
---|---|---|---|---|
CIN | 1.192 | 0.480 | 2.962 | 0.706 |
Injury Severity Score | 1.098 | 1.066 | 1.130 | < 0.001 |
Lactate level (logarithmic) | 1.618 | 0.533 | 4.916 | 0.396 |
Gender (male) | 1.051 | 0.446 | 2.480 | 0.909 |
Age (years) | 1.030 | 1.013 | 1.047 | < 0.001 |