nach oben

Erschienen in:

01.03.2014 | Original Article

Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population: a 3-year follow-up of the ROAD study

verfasst von: N. Yoshimura, K. Nagata, S. Muraki, H. Oka, M. Yoshida, Y. Enyo, R. Kagotani, H. Hashizume, H. Yamada, Y. Ishimoto, M. Teraguchi, S. Tanaka, H. Kawaguchi, Y. Toyama, K. Nakamura, T. Akune

Erschienen in: Osteoporosis International | Ausgabe 3/2014

Einloggen, um Zugang zu erhalten

Abstract

Summary

The prevalence of radiographic cervical ossification of the posterior longitudinal ligament (OPLL) in 1,562 Japanese from a population-based cohort was 1.9 %. The presence of OPLL showed a significant association with the femoral neck bone mineral density (BMD), presence of diffuse idiopathic skeletal hyperostosis (DISH) and plasma pentosidine levels. Only one new case of radiographic OPLL was detected, but OPLL progressed in all affected subjects.

Introduction

The purpose of this study was to clarify the prevalence and progression of radiographic OPLL and the associated factors, using the population-based cohort Research on Osteoarthritis/osteoporosis Against Disability (ROAD).

Methods

In the ROAD study, 1,690 participants underwent X-ray examination of the entire spine and both knees. Radiographic OPLL, lumbar spondylosis, knee osteoarthritis and DISH were diagnosed by a single, well-experienced orthopaedic surgeon. An interviewer-administered questionnaire and tests for anthropometric measurements were administered, and the BMDs of the lumbar spine and proximal femur were determined. A new OPLL case was considered if heterotopic ossification in the posterior longitudinal ligament was absent at baseline but present during follow-up. Progression was defined as an increase in the maximum length or width of the ossification at follow-up over that at baseline.

Results

Radiographic OPLL was detected in 30 (17 men, 13 women) of 1,562 individuals who underwent X-ray examination of the cervical spine (prevalence = 1.9 %). Its prevalence was significantly higher in men than in women (p = 0.007), but no association with age was observed. In a logistic regression analysis, OPLL showed a significant association with the femoral neck BMD, presence of DISH and plasma pentosidine levels. Only one new case of radiographic OPLL was detected, but OPLL progressed in all affected subjects.

Conclusion

This population-based study clarified the prevalence of radiographic OPLL in the Japanese population as well as its progression. OPLL showed significant association with plasma pentosidine levels, BMD and DISH.

Nur mit Berechtigung zugänglich

Sakou T, Matsunaga S, Koga H (2000) Recent progress in the study of pathogenesis of ossification of the posterior longitudinal ligament. J Orthop Sci 5:310–315PubMedCrossRef

Schmidt MH, Quinones-Hinojosa A, Rosenberg WS (2002) Cervical myelopathy associated with degenerative spine disease and ossification of the posterior longitudinal ligament. Semin Neurol 22:143–148PubMedCrossRef

Tsuyama N (1984) Ossification of the posterior longitudinal ligament of the spine. Clin Orthop Relat Res 184:71–84PubMed

Inamasu J, Guiot BH, Sachs DC (2006) Ossification of the posterior longitudinal ligament: an update on its biology, epidemiology, and natural history. Neurosurgery 58:1027–1039PubMedCrossRef

Kobashi G, Washio M, Okamoto K, Sasaki S, Yokoyama T, Miyake Y, Sakamoto N, Ohta K, Inaba Y, Tanaka H, Japan Collaborative Epidemiological Study Group for Evaluation of Ossification of the Posterior Longitudinal Ligament of the Spine Risk (2004) High body mass index after age 20 and diabetes mellitus are independent risk factors for ossification of the posterior longitudinal ligament of the spine in Japanese subjects: a case–control study in multiple hospitals. Spine 29:1006–1010PubMedCrossRef

Shingyouchi Y, Nagahama A, Niida M (1996) Ligamentous ossification of the cervical spine in the late middle-aged Japanese men. Its relation to body mass index and glucose metabolism. Spine 21:2474–2478PubMedCrossRef

McAfee PC, Regan JJ, Bohlman HH (1987) Cervical cord compression from ossification of the posterior longitudinal ligament in non-orientals. J Bone Joint Surg Br 69:569–575PubMed

Ehara S, Shimamura T, Nakamura R, Yamazaki K (1998) Paravertebral ligamentous ossification: DISH, OPLL and OLF. Eur J Radiol 27:196–205PubMedCrossRef

Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T (2010) Cohort profile: Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study. Int J Epidemiol 39:988–995PubMedCrossRef

10.

Yoshimura N, Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Yoshida H, Suzuki T, Yamamoto S, Ishibashi H, Kawaguchi H, Nakamura K, Akune T (2009) Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab 27:620–628. doi:10.1007/s00774-009-0080-8 PubMedCrossRef

11.

Orwoll E, Blank JB, Barrett-Connor E, Cauley J, Cummings S, Ensrud K, Lewis C, Cawthon PM, Marcus R, Marshall LM, McGowan J, Phipps K, Sherman S, Stefanick ML, Stone K (2005) Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study: a large observational study of the determinants of fracture in older men. Contemp Clin Trials 26:569–585PubMedCrossRef

12.

Kellgren JH, Lawrence LS (1957) Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16:494–502PubMedCrossRef

13.

Resnick D, Niwayama G (1976) Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology 119:559–568PubMed

14.

Sanaka T, Funaki T, Tanaka T, Hoshi S, Niwayama J, Taitoh T, Nishimura H, Higuchi C (2002) Plasma pentosidine levels measured by a newly developed method using ELISA in patients with chronic renal failure. Nephron 91:64–73PubMedCrossRef

15.

Matsunaga S, Yamaguchi M, Hayashi K, Sakou T (1999) Genetic analysis of ossification of the posterior longitudinal ligament. Spine (Phila Pa 1976) 24:937–938CrossRef

16.

Okamoto K, Kobashi G, Washio M, Sasaki S, Yokoyama T, Miyake Y, Sakamoto N, Ohta K, Inaba Y, Tanaka H, Japan Collaborative Epidemiological Study Group for Evaluation of Ossification of the Posterior Longitudinal Ligament of the Spine (OPLL) Risk (2004) Dietary habits and risk of ossification of the posterior longitudinal ligaments of the spine (OPLL); findings from a case–control study in Japan. J Bone Miner Metab 22:612–617PubMedCrossRef

17.

Washio M, Kobashi G, Okamoto K, Sasaki S, Yokoyama T, Miyake Y, Sakamoto N, Ohta K, Inaba Y, Tanaka H, Japan Collaborative Epidemiological Study Group for Evaluation of Ossification of the Posterior Longitudinal Ligament of the Spine Risk (2004) Sleeping habit and other life styles in the prime of life and risk for ossification of the posterior longitudinal ligament of the spine (OPLL): a case–control study in Japan. J Epidemiol 14:168–173PubMedCrossRef

18.

Jin BH, Kim YS (1991) Ossification of spinal ligaments. J Korean Neurosurg Soc 20:875–884

19.

Kim TJ, Bae KW, Uhm WS, Kim TH, Joo KB, Jun JB (2008) Prevalence of ossification of the posterior longitudinal ligament of the cervical spine. Joint Bone Spine 75:471–474, dPubMedCrossRef

20.

Wang PN, Chen SS, Liu HC, Fuh JL, Kuo BI, Wang SJ (1999) Ossification of the posterior longitudinal ligament of the spine. A case–control risk factor study. Spine (Phila Pa 1976) 24:142–145CrossRef

21.

Resnick D (1994) Diagnosis of bone and joint disorders. Saunders, London, pp 1496–1507

22.

Otsuka K, Terayama K, Yanagihara M (1986) An epidemiological survey on ossification of ligaments in the cervical and thoracic spine in individuals over 50 years of age. J Jpn Orthop Assoc 60:1087–1098

23.

Akune T, Ogata N, Seichi A, Ohnishi I, Nakamura K, Kawaguchi H (2001) Insulin secretory response is positively associated with the extent of ossification of the posterior longitudinal ligament of the spine. J Bone Joint Surg Am 183A:1537–1544

24.

Matsui H, Yudoh K, Tsuji H (1996) Significance of serum levels of type I procollagen peptide and intact osteocalcin and bone mineral density in patients with ossification of the posterior longitudinal ligaments. Calcif Tissue Int 59:397–400PubMedCrossRef

25.

Brownlee M (1995) Advanced protein glycosylation in diabetes and aging. Annu Rev Med 46:223–234PubMedCrossRef

26.

Brownlee M, Cerami A, Vlassara H (1988) Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med 318:1315–1321PubMedCrossRef

27.

Hernandez CJ, Tang SY, Baumbach BM, Hwu PB, Sakkee AN, van der Ham F, DeGroot J, Bank RA, Keaveny TM (2005) Trabecular microfracture and the influence of pyridinium and non-enzymatic glycation-mediated collagen crosslinks. Bone 37:825–832PubMedCentralPubMedCrossRef

28.

Wang X, Shen X, Li X, Agrawal CM (2002) Age-related changes in the collagen network and toughness of bone. Bone 31:1–7PubMedCrossRef

29.

Viguet-Carrin S, Roux JP, Arlot ME, Merabet Z, Leeming DJ, Byrjalsen I, Delmas PD, Bouxsein ML (2006) Contribution of the advanced glycation end product pentosidine and of maturation of type I collagen to compressive biomechanical properties of human lumbar vertebrae. Bone 39:1073–1079PubMedCrossRef

30.

Yamamoto M, Yamaguchi T, Yamauchi M, Yano S, Sugimoto T (2008) Serum pentosidine levels are positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes. J Clin Endocrinol Metab 93:1013–1019PubMedCrossRef

31.

Hricik DE, Schulak JA, Sell DR, Fogarty JF, Monnier VM (1993) Effects of kidney or kidney–pancreas transplantation on plasma pentosidine. Kidney Int 43:398–403PubMedCrossRef

32.

Sugiyama S, Miyata T, Ueda Y, Tanaka H, Maeda K, Kawashima S, Ypersele V, de Strihou C, Kurokawa K (1998) Plasma levels of pentosidine in diabetic patients: an advanced glycation end product. J Am Soc Nephrol 9:1681–1688PubMed

33.

Miyata T, Ueda Y, Shinzato T, Iida Y, Tanaka S, Kurokawa K, van Ypersele de Strihou C, Maeda K (1996) Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: renal implications in the pathophysiology of pentosidine. J Am Soc Nephrol 7:1198–1206PubMed

34.

Hirai N, Ikata T, Murase M, Morita T, Katoh S (1995) Bone mineral density of the lumbar spine in patients with ossification of the posterior longitudinal ligament of the cervical spine. J Spinal Disord 8:337–341PubMedCrossRef

35.

Yamauchi T, Taketomi E, Matsunaga S, Sakou T (1999) Bone mineral density in patients with ossification of the posterior longitudinal ligament in the cervical spine. J Bone Miner Metab 17:296–300PubMedCrossRef

36.

Morio Y, Yamamoto K, Kishimoto H, Hagino H, Kuranobu K, Kagawa T (1993) Bone mineral density of the radius in patients with ossification of the cervical posterior longitudinal ligament. A longitudinal study. Spine 18:2513–2516PubMedCrossRef

37.

Havelka S, Vesela M, Pavelkova A, Ruzickova S, Koga H, Maeda S, Inoue I, Halman L (2001) Are DISH and OPLL genetically related? Ann Rheum Dis 60:902–903PubMed

38.

Chiba K, Yamamoto I, Hirabayashi H, Iwasaki M, Goto H, Yonenobu K, Toyama Y (2005) Multicenter study investigating the postoperative progression of ossification of the posterior longitudinal ligament in the cervical spine: a new computer-assisted measurement. J Neurosurg Spine 3:17–23PubMedCrossRef

39.

Murakami M, Seichi A, Chikuda H, Takeshita K, Nakamura K, Kimura A (2010) Long-term follow-up of the progression of ossification of the posterior longitudinal ligament. Case report. J Neurosurg Spine 12:577–579PubMedCrossRef

Titel: Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population: a 3-year follow-up of the ROAD study
verfasst von: N. Yoshimura
K. Nagata
S. Muraki
H. Oka
M. Yoshida
Y. Enyo
R. Kagotani
H. Hashizume
H. Yamada
Y. Ishimoto
M. Teraguchi
S. Tanaka
H. Kawaguchi
Y. Toyama
K. Nakamura
T. Akune
Publikationsdatum: 01.03.2014
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 3/2014
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-013-2489-0

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen.
» Jetzt entdecken

Neu im Fachgebiet Orthopädie und Unfallchirurgie

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Arthroskopie kann Knieprothese nicht hinauszögern

25.04.2024 Gonarthrose Nachrichten

Ein arthroskopischer Eingriff bei Kniearthrose macht im Hinblick darauf, ob und wann ein Gelenkersatz fällig wird, offenbar keinen Unterschied.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Summary

Introduction

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2014

Diffuse osteosclerosis in a patient with prostate cancer

Risk of osteonecrosis in patients taking bisphosphonates for prevention of osteoporosis: a systematic review and meta-analysis

Profile of changes in bone turnover markers during once-weekly teriparatide administration for 24 weeks in postmenopausal women with osteoporosis

Fracture risk among older men: osteopenia and osteoporosis defined using cut-points derived from female versus male reference data

Maternal vitamin D status in pregnancy and offspring bone development: the unmet needs of vitamin D era