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Erschienen in: Der Urologe 10/2017

17.08.2017 | Zytostatische Therapie | Evidenzbasierte Medizin

Primärprophylaxe zur Vermeidung thrombembolischer Ereignisse bei ambulanten Tumorpatienten unter Chemotherapie

verfasst von: PD Dr. L.-M. Krabbe, B. Krabbe

Erschienen in: Die Urologie | Ausgabe 10/2017

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Di Nisio M, Porreca E, Candeloro M, De Tursi M, Russi I, Rutjes AW. Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy. Cochrane Database Syst Rev. 2016 Dec 1;12:CD008500. …
Literatur
1.
Zurück zum Zitat Agnelli G, George DJ, Kakkar AK, Fisher W, Lassen MR, Mismetti P, SAVE-ONCO Investigators et al (2012) Semuloparin for thromboprophylaxis in patients receiving chemotherapy for cancer. N Engl J Med 366(7):601–609CrossRefPubMed Agnelli G, George DJ, Kakkar AK, Fisher W, Lassen MR, Mismetti P, SAVE-ONCO Investigators et al (2012) Semuloparin for thromboprophylaxis in patients receiving chemotherapy for cancer. N Engl J Med 366(7):601–609CrossRefPubMed
2.
Zurück zum Zitat Agnelli G, Gussoni G, Bianchini C, Verso M, Mandala M, Cavanna L et al (2009) Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, doubleblind study. Lancet Oncol 10(10):943–949CrossRefPubMed Agnelli G, Gussoni G, Bianchini C, Verso M, Mandala M, Cavanna L et al (2009) Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, doubleblind study. Lancet Oncol 10(10):943–949CrossRefPubMed
3.
Zurück zum Zitat Altinbas M, Coskun HS, Er O, Ozkan M, Eser B, Unal A et al (2004) A randomized clinical trial of combination chemotherapy with and without low-molecular-weight heparin in small cell lung cancer. J Thromb Haemost 2(8):1266–1271CrossRefPubMed Altinbas M, Coskun HS, Er O, Ozkan M, Eser B, Unal A et al (2004) A randomized clinical trial of combination chemotherapy with and without low-molecular-weight heparin in small cell lung cancer. J Thromb Haemost 2(8):1266–1271CrossRefPubMed
4.
Zurück zum Zitat Di Nisio M, Porreca E, Candeloro M, De Tursi M, Russi I, Rutjes AW (2016) Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy. Cochrane Database Syst Rev 12:CD008500PubMed Di Nisio M, Porreca E, Candeloro M, De Tursi M, Russi I, Rutjes AW (2016) Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy. Cochrane Database Syst Rev 12:CD008500PubMed
5.
Zurück zum Zitat Elit LM, Lee AY, Parpia S, Swystun LL, Liaw PC, Hoskins P et al (2012) Dalteparin low molecular weight heparin (LMWH) in ovarian cancer: a phase II randomized study. Thromb Res 130:894–900CrossRefPubMed Elit LM, Lee AY, Parpia S, Swystun LL, Liaw PC, Hoskins P et al (2012) Dalteparin low molecular weight heparin (LMWH) in ovarian cancer: a phase II randomized study. Thromb Res 130:894–900CrossRefPubMed
6.
Zurück zum Zitat Haas S, Encke A, Kopp I (2016) German S3 guideline for the prevention of venous thromboembolism updated Comment on Vasa Supplement 92. Vasa 45(5):347–348CrossRefPubMed Haas S, Encke A, Kopp I (2016) German S3 guideline for the prevention of venous thromboembolism updated Comment on Vasa Supplement 92. Vasa 45(5):347–348CrossRefPubMed
7.
Zurück zum Zitat Haas SK, Freund M, Heigener D, Heilmann L, Kemkes-Matthes B, von Tempelhoff GF, TOPIC Investigators (2012) Lowmolecular-weight heparin versus placebo for the prevention of venous thromboembolism in metastatic breast cancer or stage III/IV lung cancer. Clin Appl Thromb Hemost 18(2):159–165CrossRefPubMed Haas SK, Freund M, Heigener D, Heilmann L, Kemkes-Matthes B, von Tempelhoff GF, TOPIC Investigators (2012) Lowmolecular-weight heparin versus placebo for the prevention of venous thromboembolism in metastatic breast cancer or stage III/IV lung cancer. Clin Appl Thromb Hemost 18(2):159–165CrossRefPubMed
8.
Zurück zum Zitat Kakkar AK, Levine MN, Kadziola Z, Lemoine NR, Low V, Patel HK et al (2004) Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS). J Clin Oncol 22(10):1944–1948CrossRefPubMed Kakkar AK, Levine MN, Kadziola Z, Lemoine NR, Low V, Patel HK et al (2004) Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS). J Clin Oncol 22(10):1944–1948CrossRefPubMed
9.
Zurück zum Zitat Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW (2008) Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood 111(10):4902–4907 Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW (2008) Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood 111(10):4902–4907
10.
Zurück zum Zitat Khorana AA, Francis CW, Kuderer N, Carrier M, Ortel TL, Wun T et al (2015) Dalteparin thromboprophylaxis in cancer patients at high risk for venous thromboembolism: a randomized trial. Blood 126:427CrossRef Khorana AA, Francis CW, Kuderer N, Carrier M, Ortel TL, Wun T et al (2015) Dalteparin thromboprophylaxis in cancer patients at high risk for venous thromboembolism: a randomized trial. Blood 126:427CrossRef
11.
Zurück zum Zitat Klerk CP, Smorenburg SM, Otten HM, Lensing AW, Prins MH, Piovella F et al (2005) The effect of low molecular weight heparin on survival in patients with advanced malignancy. J Clin Oncol 23(10):2130–2135CrossRefPubMed Klerk CP, Smorenburg SM, Otten HM, Lensing AW, Prins MH, Piovella F et al (2005) The effect of low molecular weight heparin on survival in patients with advanced malignancy. J Clin Oncol 23(10):2130–2135CrossRefPubMed
12.
Zurück zum Zitat Larocca A, Cavallo F, Bringhen S, Di Raimondo F, Falanga A, Evangelista A et al (2012) Aspirin or enoxaparin thromboprophylaxis for patients with newly diagnosed multiple myeloma treated with lenalidomide. Blood 119(4):933–939CrossRefPubMed Larocca A, Cavallo F, Bringhen S, Di Raimondo F, Falanga A, Evangelista A et al (2012) Aspirin or enoxaparin thromboprophylaxis for patients with newly diagnosed multiple myeloma treated with lenalidomide. Blood 119(4):933–939CrossRefPubMed
13.
Zurück zum Zitat Lecumberri R, Lopez VG, Font A, Gonzalez BE, Gurpide A, Gomez CJ et al (2013) Adjuvant therapy with bemiparin in patients with limited-stage small cell lung cancer: Results from the ABEL study. Thromb Res 132:666–670CrossRefPubMed Lecumberri R, Lopez VG, Font A, Gonzalez BE, Gurpide A, Gomez CJ et al (2013) Adjuvant therapy with bemiparin in patients with limited-stage small cell lung cancer: Results from the ABEL study. Thromb Res 132:666–670CrossRefPubMed
14.
Zurück zum Zitat Levine MN, Gu C, Liebman HA, Escalante CP, Solymoss S, Deitchman D et al (2012) A randomized phase II trial of Apixaban for the prevention of thromboembolism in patients with metastatic cancer. J Thromb Haemost 10(5):807–814CrossRefPubMed Levine MN, Gu C, Liebman HA, Escalante CP, Solymoss S, Deitchman D et al (2012) A randomized phase II trial of Apixaban for the prevention of thromboembolism in patients with metastatic cancer. J Thromb Haemost 10(5):807–814CrossRefPubMed
15.
Zurück zum Zitat Macbeth F, Noble S, Evans J, Ahmed S, Cohen D, Hood K et al (2016) Randomized phase III trial of standard therapy plus low molecular weight heparin in patients with lung cancer: FRAGMATIC trial. J Clin Oncol 34:488–494CrossRefPubMed Macbeth F, Noble S, Evans J, Ahmed S, Cohen D, Hood K et al (2016) Randomized phase III trial of standard therapy plus low molecular weight heparin in patients with lung cancer: FRAGMATIC trial. J Clin Oncol 34:488–494CrossRefPubMed
16.
Zurück zum Zitat Maraveyas A, Waters J, Roy R, Fyfe D, Propper D, Lofts F et al (2012) Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer. Eur J Cancer 48(9):1283–1292CrossRefPubMed Maraveyas A, Waters J, Roy R, Fyfe D, Propper D, Lofts F et al (2012) Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer. Eur J Cancer 48(9):1283–1292CrossRefPubMed
17.
Zurück zum Zitat Palumbo A, Cavo M, Bringhen S, Zamagni E, Romano A, Patriarca F et al (2011) Aspirin, warfarin, or enoxaparin thromboprophylaxis in patients with multiple myeloma treated with thalidomide: a phase III, open-label, randomized trial. J Clin Oncol 29:986–993CrossRefPubMed Palumbo A, Cavo M, Bringhen S, Zamagni E, Romano A, Patriarca F et al (2011) Aspirin, warfarin, or enoxaparin thromboprophylaxis in patients with multiple myeloma treated with thalidomide: a phase III, open-label, randomized trial. J Clin Oncol 29:986–993CrossRefPubMed
18.
Zurück zum Zitat Pelzer U, Opitz B, Deutschinoff G, Stauch M, Reitzig PC, Hahnfeld S et al (2015) Efficacy of prophylactic low-molecular weight heparin for ambulatory patients with advanced pancreatic cancer: outcomes from the CONKO-004 Trial. J Clin Oncol 33:2028–2034CrossRefPubMed Pelzer U, Opitz B, Deutschinoff G, Stauch M, Reitzig PC, Hahnfeld S et al (2015) Efficacy of prophylactic low-molecular weight heparin for ambulatory patients with advanced pancreatic cancer: outcomes from the CONKO-004 Trial. J Clin Oncol 33:2028–2034CrossRefPubMed
19.
Zurück zum Zitat Perry JR, Julian JA, Laperriere NJ, Geerts W, Agnelli G, Rogers LR et al (2010) PRODIGE: a randomized placebocontrolled trial of dalteparin low-molecular-weight heparin thromboprophylaxis in patients with newly diagnosed malignant glioma. J Thromb Haemost 8(9):1959–1965CrossRefPubMed Perry JR, Julian JA, Laperriere NJ, Geerts W, Agnelli G, Rogers LR et al (2010) PRODIGE: a randomized placebocontrolled trial of dalteparin low-molecular-weight heparin thromboprophylaxis in patients with newly diagnosed malignant glioma. J Thromb Haemost 8(9):1959–1965CrossRefPubMed
20.
Zurück zum Zitat Schulman S, Kearon C, Subcommittee on control of anticoagulation of the Scientific and Standardization committee of the International Society on Thrombosis and Haemostasis (2005) Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. Scientific and Standardization Committee Communication. J Thromb Haemost 3:692–694CrossRefPubMed Schulman S, Kearon C, Subcommittee on control of anticoagulation of the Scientific and Standardization committee of the International Society on Thrombosis and Haemostasis (2005) Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. Scientific and Standardization Committee Communication. J Thromb Haemost 3:692–694CrossRefPubMed
21.
Zurück zum Zitat Sideras K, Schaefer PL, Okuno SH, Sloan JA, Kutteh L, Fitch TR et al (2006) Low-molecular-weight heparin in patients with advanced cancer: a phase 3 clinical trial. Mayo Clin Proc 81(6):758–767CrossRefPubMed Sideras K, Schaefer PL, Okuno SH, Sloan JA, Kutteh L, Fitch TR et al (2006) Low-molecular-weight heparin in patients with advanced cancer: a phase 3 clinical trial. Mayo Clin Proc 81(6):758–767CrossRefPubMed
22.
Zurück zum Zitat Vadhan-Raj S, Zhou X, Varadhachary GR, Milind J, Fogelman D, Shroff R et al (2013) Randomized controlled trial of dalteparin for primary thromboprophylaxis for venous thromboembolism (VTE) in patients with advanced pancreatic cancer (APC): risk factors predictive of VTE. In: 55th Annual Meeting of the American Society of Hematology, Bd. 21. Vadhan-Raj S, Zhou X, Varadhachary GR, Milind J, Fogelman D, Shroff R et al (2013) Randomized controlled trial of dalteparin for primary thromboprophylaxis for venous thromboembolism (VTE) in patients with advanced pancreatic cancer (APC): risk factors predictive of VTE. In: 55th Annual Meeting of the American Society of Hematology, Bd. 21.
23.
Zurück zum Zitat van Doormaal FF, Di Nisio M, Otten H‑M, Richel DJ, Prins M, Buller HR (2011) Randomized trial of the effect of the low molecular weight heparin nadroparin on survival in patients with cancer. J Clin Oncol 29(15):2071–2076CrossRefPubMed van Doormaal FF, Di Nisio M, Otten H‑M, Richel DJ, Prins M, Buller HR (2011) Randomized trial of the effect of the low molecular weight heparin nadroparin on survival in patients with cancer. J Clin Oncol 29(15):2071–2076CrossRefPubMed
24.
Zurück zum Zitat Zwicker JI, Liebman HA, Bauer KA, Caughey T, Campigotto F, Rosovsky R et al (2013) Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study). Br J Haematol 160(4):530–537CrossRefPubMed Zwicker JI, Liebman HA, Bauer KA, Caughey T, Campigotto F, Rosovsky R et al (2013) Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study). Br J Haematol 160(4):530–537CrossRefPubMed
Metadaten
Titel
Primärprophylaxe zur Vermeidung thrombembolischer Ereignisse bei ambulanten Tumorpatienten unter Chemotherapie
verfasst von
PD Dr. L.-M. Krabbe
B. Krabbe
Publikationsdatum
17.08.2017
Verlag
Springer Medizin
Erschienen in
Die Urologie / Ausgabe 10/2017
Print ISSN: 2731-7064
Elektronische ISSN: 2731-7072
DOI
https://doi.org/10.1007/s00120-017-0489-y

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