Skip to main content
Erschienen in: HSS Journal ® 2/2007

01.09.2007 | CPC

Primary Antiphospholipid Syndrome Presenting as HELLP Syndrome

A Clinical Pathology Conference Held by the Division of Rheumatology at Hospital for Special Surgery

verfasst von: Diane George, MD, Lisa Vasanth, MD, Doruk Erkan, MD, Anne Bass, MD, Jane Salmon, MD, Michael D. Lockshin, MD

Erschienen in: HSS Journal ® | Ausgabe 2/2007

Einloggen, um Zugang zu erhalten

Excerpt

A 29-year-old woman (gravida 1, para 0) was transferred to New York Presbyterian Hospital (NYPH) for the evaluation of complete vision loss in the left eye, which occurred 4 days after an emergency medical abortion because of hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. …
Literatur
1.
Zurück zum Zitat Salafia CM, Pezzulo JC, Lopez-Zeno JA, Minior VK et al (1995) Placental pathologic features of preterm pre-eclampsia. Am J Obstet Gynecol 173(4):1097–1105PubMedCrossRef Salafia CM, Pezzulo JC, Lopez-Zeno JA, Minior VK et al (1995) Placental pathologic features of preterm pre-eclampsia. Am J Obstet Gynecol 173(4):1097–1105PubMedCrossRef
2.
Zurück zum Zitat Shanklin DR, Sibai BM (1989) Ultrastructural aspects of preeclampsia I. Placental bed and uterine boundary vessels. Am J Obstet Gynecol 161(3):735–741PubMed Shanklin DR, Sibai BM (1989) Ultrastructural aspects of preeclampsia I. Placental bed and uterine boundary vessels. Am J Obstet Gynecol 161(3):735–741PubMed
3.
Zurück zum Zitat Martin JN Jr, Rinehart BK, May WL et al (1999) The spectrum of severe preeclampsia: Comparative analysis by HELLP (hemolysis, elevated liver enzyme levels, and low platelet count) syndrome classification. Am J Obstet Gynecol 180(6 Pt 1):1373–1384PubMedCrossRef Martin JN Jr, Rinehart BK, May WL et al (1999) The spectrum of severe preeclampsia: Comparative analysis by HELLP (hemolysis, elevated liver enzyme levels, and low platelet count) syndrome classification. Am J Obstet Gynecol 180(6 Pt 1):1373–1384PubMedCrossRef
4.
Zurück zum Zitat Curtin WM, Weinstein L (1999) A Review of HELLP syndrome: State of the Art. J Perinatol 19(2):138–143PubMedCrossRef Curtin WM, Weinstein L (1999) A Review of HELLP syndrome: State of the Art. J Perinatol 19(2):138–143PubMedCrossRef
5.
Zurück zum Zitat Baxter JK, Weinstein L (2004) HELLP syndrome: the state of the art. Obstet Gynecol Surv 59(12):838–845PubMedCrossRef Baxter JK, Weinstein L (2004) HELLP syndrome: the state of the art. Obstet Gynecol Surv 59(12):838–845PubMedCrossRef
6.
Zurück zum Zitat Wilson WA, Gharavi AE, Koike T et al (1999) International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 42(7):1309–1311PubMedCrossRef Wilson WA, Gharavi AE, Koike T et al (1999) International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 42(7):1309–1311PubMedCrossRef
7.
Zurück zum Zitat Miyakis S, Lockshin MD, Atsumi T et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4(2):295–306PubMedCrossRef Miyakis S, Lockshin MD, Atsumi T et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4(2):295–306PubMedCrossRef
8.
Zurück zum Zitat Branch DW, Silver RM, Blackwell JL, Reading JC, Scott JR (1992) Outcome of treated pregnancies in women with antiphospholipid syndrome: an update of the Utah experience. Obstet Gynecol 80(4):614–620PubMed Branch DW, Silver RM, Blackwell JL, Reading JC, Scott JR (1992) Outcome of treated pregnancies in women with antiphospholipid syndrome: an update of the Utah experience. Obstet Gynecol 80(4):614–620PubMed
9.
Zurück zum Zitat Le Thi Thuong D, Tieulie N, Costedoat N et al (2005) The HELLP syndrome in the antiphospholipid syndrome: retrospective study of 16 cases in 15 women. Ann Rheum Dis 64(2):273–278PubMedCrossRef Le Thi Thuong D, Tieulie N, Costedoat N et al (2005) The HELLP syndrome in the antiphospholipid syndrome: retrospective study of 16 cases in 15 women. Ann Rheum Dis 64(2):273–278PubMedCrossRef
10.
Zurück zum Zitat Huong DL, Wechsler B, Bletry O et al (2001) A study of 75 pregnancies in patients with the antiphospholipid syndrome. J Rheumatol 28:2025–2030PubMed Huong DL, Wechsler B, Bletry O et al (2001) A study of 75 pregnancies in patients with the antiphospholipid syndrome. J Rheumatol 28:2025–2030PubMed
11.
Zurück zum Zitat Branch DW, Scott JR, Kochenour NK et al (1985) Obstetric complications associated with the lupus anticoagulant. N Engl J Med 313(21):1322–1326PubMedCrossRef Branch DW, Scott JR, Kochenour NK et al (1985) Obstetric complications associated with the lupus anticoagulant. N Engl J Med 313(21):1322–1326PubMedCrossRef
12.
Zurück zum Zitat Rote NS, Walter A, Lyden TW et al (1992) Antiphospholipid antibodies—lobsters or red herrings. Am J Reprod Immunol 28(1):31–37PubMed Rote NS, Walter A, Lyden TW et al (1992) Antiphospholipid antibodies—lobsters or red herrings. Am J Reprod Immunol 28(1):31–37PubMed
13.
Zurück zum Zitat Sammaritano LR (2001) Update on the management of the pregnant patient with antiphospholipid antibody. Curr Rheumatol Rep 3(3):213–221PubMedCrossRef Sammaritano LR (2001) Update on the management of the pregnant patient with antiphospholipid antibody. Curr Rheumatol Rep 3(3):213–221PubMedCrossRef
14.
Zurück zum Zitat Erkan D (2002) The relation between antiphospholipid syndrome-related pregnancy morbidity and non-gravid vascular thrombosis: review of the literature and management strategies. Curr Rheumatol Rep 4(5):379–386PubMedCrossRef Erkan D (2002) The relation between antiphospholipid syndrome-related pregnancy morbidity and non-gravid vascular thrombosis: review of the literature and management strategies. Curr Rheumatol Rep 4(5):379–386PubMedCrossRef
15.
Zurück zum Zitat Magid MS, Kaplan C, Sammaritano LR et al (1998) Placental pathology in systemic lupus erythematosus: a prospective study. Am J Obstet Gynecol 179(1):226–234PubMedCrossRef Magid MS, Kaplan C, Sammaritano LR et al (1998) Placental pathology in systemic lupus erythematosus: a prospective study. Am J Obstet Gynecol 179(1):226–234PubMedCrossRef
16.
Zurück zum Zitat Van Horn JT, Craven C, Ward K et al (2004) Histologic features of placentas and abortion specimens from women with antiphospholipid and antiphospholipid like syndromes. Placenta 25(7):642–648PubMedCrossRef Van Horn JT, Craven C, Ward K et al (2004) Histologic features of placentas and abortion specimens from women with antiphospholipid and antiphospholipid like syndromes. Placenta 25(7):642–648PubMedCrossRef
17.
Zurück zum Zitat Infante-Rievard C, David M, Gauthier R et al (1991) Lupus anticoagulants, anticardiolipin antibodies and fetal loss. N Engl J Med 325(15):1063–1066CrossRef Infante-Rievard C, David M, Gauthier R et al (1991) Lupus anticoagulants, anticardiolipin antibodies and fetal loss. N Engl J Med 325(15):1063–1066CrossRef
18.
Zurück zum Zitat Rand JH, Wu XX, Andree HA et al (1997) Pregnancy loss in the antiphospholipid–antibody syndrome—a possible thrombogenic mechanism. N Engl J Med 337(3):154–160.PubMedCrossRef Rand JH, Wu XX, Andree HA et al (1997) Pregnancy loss in the antiphospholipid–antibody syndrome—a possible thrombogenic mechanism. N Engl J Med 337(3):154–160.PubMedCrossRef
19.
Zurück zum Zitat Simantov R, LaSala J, Lo SK et al (1995) Activation of cultured vascular endothelium by antiphospholipid antibodies. J Clin Invest 96:2211–2219PubMedCrossRef Simantov R, LaSala J, Lo SK et al (1995) Activation of cultured vascular endothelium by antiphospholipid antibodies. J Clin Invest 96:2211–2219PubMedCrossRef
20.
Zurück zum Zitat Pierangeli SS, Colden-Stanfield M, Liu X et al (1999) Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 99(15):1997–2002PubMed Pierangeli SS, Colden-Stanfield M, Liu X et al (1999) Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 99(15):1997–2002PubMed
21.
Zurück zum Zitat Branch DW, Dudley DJ, Mitchell MD et al (1990) Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BABL/c mice: a model for autoimmune fetal loss. Am J Obstet Gynecol 163(1 Pt 1):210–216PubMed Branch DW, Dudley DJ, Mitchell MD et al (1990) Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BABL/c mice: a model for autoimmune fetal loss. Am J Obstet Gynecol 163(1 Pt 1):210–216PubMed
22.
Zurück zum Zitat Holers VM, Girardi G, Guthridge GM et al (2002) Complement C3 activation is required for antiphospholipid antibody-induced fetal loss. J Exp Med 195(2):211–220PubMedCrossRef Holers VM, Girardi G, Guthridge GM et al (2002) Complement C3 activation is required for antiphospholipid antibody-induced fetal loss. J Exp Med 195(2):211–220PubMedCrossRef
23.
Zurück zum Zitat Girardi G, Redecha P, Berman J et al (2004) Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 112(11):1644–1654CrossRef Girardi G, Redecha P, Berman J et al (2004) Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 112(11):1644–1654CrossRef
24.
Zurück zum Zitat Pierangeli SS, Girardi G, Vega-Ostertag M et al (2005) Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Arthritis Rheum 52(7):2120–2124PubMedCrossRef Pierangeli SS, Girardi G, Vega-Ostertag M et al (2005) Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Arthritis Rheum 52(7):2120–2124PubMedCrossRef
25.
Zurück zum Zitat Girardi G, Redecha P, Salmon JE (2004) Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 10(11):1222–1226PubMedCrossRef Girardi G, Redecha P, Salmon JE (2004) Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 10(11):1222–1226PubMedCrossRef
26.
Zurück zum Zitat Derekson RH, De Groot PG, Kater L, Nieuwenhuis HK (1993) Patients with Antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment. Ann Rheum Dis 52:689–692 Derekson RH, De Groot PG, Kater L, Nieuwenhuis HK (1993) Patients with Antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment. Ann Rheum Dis 52:689–692
27.
Zurück zum Zitat Sibai BM (2004) Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet Gynecol 103(5 Pt 1):981-991PubMed Sibai BM (2004) Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet Gynecol 103(5 Pt 1):981-991PubMed
Metadaten
Titel
Primary Antiphospholipid Syndrome Presenting as HELLP Syndrome
A Clinical Pathology Conference Held by the Division of Rheumatology at Hospital for Special Surgery
verfasst von
Diane George, MD
Lisa Vasanth, MD
Doruk Erkan, MD
Anne Bass, MD
Jane Salmon, MD
Michael D. Lockshin, MD
Publikationsdatum
01.09.2007
Verlag
Springer-Verlag
Erschienen in
HSS Journal ® / Ausgabe 2/2007
Print ISSN: 1556-3316
Elektronische ISSN: 1556-3324
DOI
https://doi.org/10.1007/s11420-007-9043-6

Weitere Artikel der Ausgabe 2/2007

HSS Journal ® 2/2007 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Klinikreform soll zehntausende Menschenleben retten

15.05.2024 Klinik aktuell Nachrichten

Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

TEP mit Roboterhilfe führt nicht zu größerer Zufriedenheit

15.05.2024 Knie-TEP Nachrichten

Der Einsatz von Operationsrobotern für den Einbau von Totalendoprothesen des Kniegelenks hat die Präzision der Eingriffe erhöht. Für die postoperative Zufriedenheit der Patienten scheint das aber unerheblich zu sein, wie eine Studie zeigt.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.