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Archives of Gynecology and Obstetrics

Erschienen in:

05.09.2019 | Gynecologic Oncology

Primary peritoneal serous papillary carcinoma: a case series

verfasst von: Nikolaos Blontzos, Evangelos Vafias, George Vorgias, Nikolaos Kalinoglou, Christos Iavazzo

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2019

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Abstract

Purpose

To present the clinical and laboratory characteristics, as well as the management, of patients with primary peritoneal serous papillary carcinoma (PPSPC).

Methods

This is a retrospective study of 19 patients with PPSPC who underwent debulking surgery followed by first line chemotherapy and were managed in Metaxa Memorial Cancer Hospital between January 2002 and December 2017.

Results

The median age of the patients was found to be 66 years (range 44–76 years). Clinical presentation of PPSPC included abdominal distention and pain, constipation, as well as loss of appetite and weight gain. Two of the patients did not mention any symptomatology and the disease was suspected by an abnormal cervical smear and elevated CA125 levels respectively. Biomarkers measurement during the initial management of the patients revealed abnormal values of CA125 for all the participants (median value 565 U/ml). Human epididymis secretory protein 4 (HE4) and ratios of blood count were also measured. Perioperative Peritoneal Cancer Index ranged from 6 to 20. Optimal debulking was achieved in 5 cases. All patients were staged as IIIC and IVA PPSPC and received standard chemotherapy with paclitaxel and carboplatin, whereas bevacizumab was added in the 5 most recent cases. Median overall survival was 29 months.

Conclusion

PPSPC is a rare malignancy, the management of which should take place in tertiary oncology centers.

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Titel: Primary peritoneal serous papillary carcinoma: a case series
verfasst von: Nikolaos Blontzos
Evangelos Vafias
George Vorgias
Nikolaos Kalinoglou
Christos Iavazzo
Publikationsdatum: 05.09.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 4/2019
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05280-z

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Primary peritoneal serous papillary carcinoma: a case series

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