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Clinical Rheumatology

Erschienen in:

06.09.2017 | Review Article

Pristane-induced lupus: considerations on this experimental model

verfasst von: Eduarda Correa Freitas, Mayara Souza de Oliveira, Odirlei André Monticielo

Erschienen in: Clinical Rheumatology | Ausgabe 11/2017

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Abstract

Systemic lupus erythematosus (SLE) is a multifactorial, autoimmune inflammatory disease with pleomorphic clinical manifestations involving different organs and tissues. The etiology of this disease has been associated with a dysfunctional response of B and T lymphocytes against environmental stimuli in individuals genetically susceptible to SLE, which determines an immune response against different autoantigens and, consequently, tissue damage. The study of different murine models has provided a better understanding of these autoimmune phenomena. This review primarily focuses on that has been learned from the pristane-induced lupus (PIL) model and how this model can be used to supplement recent advances in understanding the pathogenesis of SLE. We also consider both current and future therapies for this disease. The PubMed, SciELO, and Embase databases were searched for relevant articles published from 1950 to 2016. PIL has been shown to be a useful tool for understanding the multiple mechanisms involved in systemic autoimmunity. In addition, it can be considered an efficient model to evaluate the environmental contributions and interferon signatures present in patients with SLE.

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Titel: Pristane-induced lupus: considerations on this experimental model
verfasst von: Eduarda Correa Freitas
Mayara Souza de Oliveira
Odirlei André Monticielo
Publikationsdatum: 06.09.2017
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 11/2017
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-017-3811-6

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