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01.12.2012 | Original Article

Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations

verfasst von: Hisashi Kawashima, Yasuyo Kashiwagi, Hiroaki Ioi, Shinichiro Morichi, Shingo Oana, Gaku Yamanaka, Kouji Takekuma, Akinori Hoshika, Jun Sawai, Yuichi Kato

Erschienen in: Journal of Infection and Chemotherapy | Ausgabe 6/2012

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Abstract

Respiratory syncytial virus (RSV) infection in children can be associated with acute encephalopathy. However, the roles of cytokines in the cerebrospinal fluid (CSF) of such patients remain unevaluated. In this study, a profile of 17 cytokines was determined for eight RSV-infected children with neurological complications. In one patient with high levels of 13 cytokines, a cytokine storm was considered to have occurred. Interleukin (IL)-6, IL-8, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1β levels were also high in other patients. These data suggest that chemokines in CSF play roles in neurological complications in RSV-infected children.

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Titel: Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations
verfasst von: Hisashi Kawashima
Yasuyo Kashiwagi
Hiroaki Ioi
Shinichiro Morichi
Shingo Oana
Gaku Yamanaka
Kouji Takekuma
Akinori Hoshika
Jun Sawai
Yuichi Kato
Publikationsdatum: 01.12.2012
Verlag: Springer Japan
Erschienen in: Journal of Infection and Chemotherapy / Ausgabe 6/2012
Print ISSN: 1341-321X
Elektronische ISSN: 1437-7780
DOI: https://doi.org/10.1007/s10156-012-0418-3

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Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations

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