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Journal of Cancer Research and Clinical Oncology

Erschienen in:

12.09.2023 | Research

Prognostic and immune correlation analysis of mitochondrial autophagy and aging-related genes in lung adenocarcinoma

verfasst von: Xiangzhi Meng, Weijian Song, Boxuan Zhou, Mei Liang, Yushun Gao

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 18/2023

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Abstract

Purpose

Mitophagy and aging (MiAg) are very important pathophysiological mechanisms contributing to tumorigenesis. MiAg-related genes have prognostic value in lung adenocarcinoma (LUAD). However, prognostic, and immune correlation studies of MiAg-related genes in LUAD are lacking.

Methods

MiAg differentially expressed genes (DEGs) in LUAD were obtained from public sequencing datasets. A prognostic model including MiAg DEGs was constructed according to patients divided into low- and high-risk groups. Gene Ontology, gene set enrichment analysis, gene set variation analysis, CIBERSORT immune infiltration analysis, and clinical characteristic correlation analyses were performed for functional annotation and correlation of MiAgs with prognosis in patients with LUAD.

Results

Seven MiAg DEGs of LUAD were identified: CAV1, DSG2, DSP, MYH11, NME1, PAICS, PLOD2, and the expression levels of these genes were significantly correlated (P < 0.05). The RiskScore of the MiAg DEG prognostic model demonstrated high predictive ability of overall survival of patients diagnosed with LUAD. Patients with high and low MiAg phenotypic scores exhibited significant differences in the infiltration levels of eight types of immune cells (P < 0.05). The multi-factor DEG regression model showed higher efficacy in predicting 5-year survival than 3- and 1-year survival of patients with LUAD.

Conclusions

Seven MiAg-related genes were identified to be significantly associated with the prognosis of patients diagnosed with LUAD. Moreover, the identified MiAg DEGs might affect the immunotherapy strategy of patients with LUAD.

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Titel: Prognostic and immune correlation analysis of mitochondrial autophagy and aging-related genes in lung adenocarcinoma
verfasst von: Xiangzhi Meng
Weijian Song
Boxuan Zhou
Mei Liang
Yushun Gao
Publikationsdatum: 12.09.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 18/2023
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-023-05390-x

Springer Medizin

Prognostic and immune correlation analysis of mitochondrial autophagy and aging-related genes in lung adenocarcinoma

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Onkologie

Erhöhte Mortalität bei postpartalem Brustkrebs

Hypertherme Chemotherapie bietet Chance auf Blasenerhalt

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

Bessere Prognose mit links- statt rechtsseitigem Kolon-Ca.

Update Onkologie

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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