Skip to main content
main-content

21.08.2018 | Clinical trial | Ausgabe 2/2018

Breast Cancer Research and Treatment 2/2018

Prognostic impact of skeletal muscle volume derived from cross-sectional computed tomography images in breast cancer

Zeitschrift:
Breast Cancer Research and Treatment > Ausgabe 2/2018
Autoren:
Eun Jin Song, Chan Wha Lee, So-Youn Jung, Byeong Nam Kim, Keun Seok Lee, Seeyoun Lee, Han-Sung Kang, In Hae Park, Moo Hyun Lee, Yun Ju Kim, Kyungran Ko, Sohee Kim, Byung-Ho Nam, Eun Sook Lee
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s10549-018-4915-7) contains supplementary material, which is available to authorized users.
Eun Jin Song, Chan Wha Lee and So-Youn Jung have contributed equally to the study. Eun Jin Song and So-Youn Jung are co-first author and Chan Wha Lee is co-corresponding author.

Abstract

Purpose

This study aimed to determine whether the prognosis of breast cancer is affected by muscle or fat volume as measured from computed tomography (CT) images.

Methods

We identified 1460 patients with chest CT who were diagnosed as having breast cancer at the National Cancer Center, Korea, between January 2001 and December 2009. Using CT images of 10-mm slices, we measured the cross-sectional areas of skeletal muscle and adipose tissue at the 3rd lumbar vertebrae, and derived their volumes. The skeletal muscle volume, fat volume, and muscle-to-fat ratio were evaluated for association with overall survival (OS) and recurrence-free survival (RFS).

Results

The median skeletal muscle and fat volumes among the patients were 93.3 cc (range 39.6–236.9) and 420.1 cc (range 19.5–1392.3), respectively. Patients with higher muscle volume had better prognosis than those with lower muscle volume [hazard ratio (HR) 0.56, 95% confidence interval (CI) 0.34–0.92, P = 0.022 for OS; HR 0.72, 95% CI 0.52–0.99, P = 0.046 for RFS]. However, body mass index (BMI) and fat volume were not associated with prognosis. In addition, muscle volume was a significant prognosticator for OS, regardless of BMI (HR 0.55, 95% CI 0.32–0.93, P = 0.034 in BMI < 25.0; HR 0.44, 95% CI 0.21–0.91, P = 0.026 in BMI ≥ 25.0). Among older patients (≥ 50), those with higher muscle volume showed better OS and RFS (HR 0.44, 95% CI 0.23–0.85, P = 0.015; HR 0.55, 95% CI 0.34–0.90, P = 0.017, respectively).

Conclusion

This study demonstrated that breast cancer patients with higher skeletal muscle volume showed more favorable prognosis.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Weitere Produktempfehlungen anzeigen
Zusatzmaterial
Supplement figure 1. Distribution of muscle volume and fat volume (TIF 134 KB)
10549_2018_4915_MOESM1_ESM.tif
Supplement figure 2. Biological subgroup analysis. A forest plot showing the hazard ratios and 95% confidence intervals associated with the variables considered in the subgroup analysis for overall survival (left) and for recurrence-free survival (right). With respect to muscle volume, the triple-negative subgroup (ER and PR and Her2 Negative) was especially associated with the statistically significant hazard ratio of overall survival and recurrence-free survival (TIF 173 KB)
10549_2018_4915_MOESM2_ESM.tif
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 2/2018

Breast Cancer Research and Treatment 2/2018 Zur Ausgabe
  1. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.

  2. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.

Neu im Fachgebiet Onkologie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Onkologie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise