Background
Methods
Results
No. |
[%]
| |
---|---|---|
Total | 157 |
100
|
Sex
| ||
Male/Female | 94/63 |
60/40
|
Age, years
| ||
median (range) | 59 · 0 (34–74) | |
Primary tumor and lymph node classification
| ||
cT1-3 N2 | 81 |
52
|
cT1-3 N3 | 35 |
22
|
cT4 N2 | 37 |
24
|
cT4 N3 | 4 |
2
|
Histology
| ||
Squamous Cell Carcinoma | 58 |
37
|
Adenocarcinoma | 75 |
48
|
Large Cell Carcinoma | 16 |
10
|
not differentiated, NOS | 7 |
4
|
sarcomatoid | 1 |
1
|
G
| ||
1 | 3 |
2
|
2 | 50 |
32
|
3 | 94 |
60
|
x | 10 |
6
|
Localisation
| ||
Sulcus Superior (Pancoast) | 9 |
6
|
Upper Lobe | 95 |
60
|
Middle Lobe/Centrally located | 30 |
19
|
Lower Lobe | 23 |
15
|
Induction Chemotherapy
| ||
Cisplatin/Etoposide | 11 |
7
|
Cisplatin/Paclitaxel | 146 |
93
|
Concurrent Chemotherapy
| ||
Cisplatin/Etoposide | 28 |
18
|
Cisplatin/Vinorelbine | 129 |
82
|
Radiotherapy Fractionation
| ||
conventional | 77 |
49
|
accelerated-hyperfractionated | 80 |
51
|
Surgery
| ||
Segmentectomy | 2 |
1
|
Lobectomy | 105 |
68
|
Bi-Lobectomy | 7 |
4
|
Pneumonectomy | 40 |
26
|
Thoracotomy without resection | 1 |
1
|
Resection
| ||
microscopic complete (R0) | 143 |
92
|
microscopic incomplete (R1) | 9 |
6
|
macroscopic incomplete (R2) | 4 |
2
|
Sensitivity and specificity of histopathologic regression parameters to predict long-term survival
Patients with cN2-3 status | ||||||
---|---|---|---|---|---|---|
Number of patients | Long-term survivors | Sensitivity | Specificity | Sensitivity/(1-specificity) | CMH-test | |
all patients | 157 | 72 | ||||
pCR | 41 | 28 | 0.38 (0.27–0.50) | 0.84 (0.77–0.92) | 2.46 (1.39–4.38) | p = 0.0012 |
Reg-grade ≥ 2B | 72 | 40 | 0.56 (0.44–0.67) | 0.62 (0.52–0.73) | 1.48 (1.05–2.08) | p = 0.025 |
Reg-grade ≥ 2A | 135 | 66 | 0.92 (0.85–0.98) | 0.19 (0.11–0.27) | 1.13 (0.99–1.28) | p = 0.057 |
pCR-T | 46 | 29 | 0.40 (0.29–0.51) | 0.80 (0.71–0.88) | 1.96 (1.18–3.25) | p = 0.008 |
MNC | 85 | 44 | 0.61 (0.50–0.72) | 0.52 (0.41–0.62) | 1.26 (0.95–1.69) | p = 0.11 |
Proportional hazard analysis of the clinical and pathological variables on survival
model (1) containing clinical + pathol. covariates | standard model (2) containing clinical covariates alone | |||
---|---|---|---|---|
variable | Hazard ratio | p-value | Hazard ratio | p-value |
pCR | 0.41 (0.25–0.67) | p = 0.0003 | not included | |
cN3 | 1.52 (1.01–2.29) | p = 0.047 | 1.59 (1.06–2.39) | p = 0.027 |
gender (female) | 0.57 (0.38–0.87) | p = 0.008 | 0.63 (0.42–0.94) | p = 0.025 |
CT - tumor response | Backward eliminated | n.s. | 0.59 (0.39–0.91) | p = 0.017 |