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European Archives of Oto-Rhino-Laryngology

Erschienen in:

25.11.2020 | Head and Neck

Prognostic outcomes of treatment naïve oral tongue squamous cell carcinoma (OTSCC): a comprehensive analysis of 14 years

verfasst von: Muhammad Faisal, Rahim Dhanani, Sami Ullah, Muhammad Abu Bakar, Nabia Irfan, Kashif Iqbal Malik, Asif Loya, Erovic M. Boban, Raza Hussain, Arif Jamshed

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 8/2021

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Abstract

Objectives

To analyze the factors predicting survival outcomes in treatment naïve oral tongue squamous cell carcinoma (OTSCC).

Materials and methods

A comprehensive review of 531 oral tongue carcinoma patients treated with upfront surgery followed by adjuvant radiotherapy or chemoradiotherapy was conducted from 2004–2018.

Results

The mean age of presentation was 53 years (11–86) with a male to female ratio of 1.3:1. The associated risk factors were smoking (21%), betel nut (16%), naswar (9%) and alcohol (1%). Most of the cases were either well (45.1%) or moderately (46.2%) differentiated. Surgery was performed in 164 patients alone while 368 were treated with surgery in combination with adjuvant modalities. Overall (OS) and disease free survival (DFS) were 66 and 71%, respectively, with a median follow up of 2.5 years. Cox regression analysis showed nodal positivity, increased depth of invasion (DOI) and higher lymph node ratio (LNR) as significant prognosticators impacting OS and DSS.

Conclusion

Nodal volume, DOI and LNR are the most consistent predictors of poor outcome in OTSCC. Nodal positivity, depth of invasion > 5 mm and lymph node ratio > 0.04 adversely affect OS and DSS.

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Titel: Prognostic outcomes of treatment naïve oral tongue squamous cell carcinoma (OTSCC): a comprehensive analysis of 14 years
verfasst von: Muhammad Faisal
Rahim Dhanani
Sami Ullah
Muhammad Abu Bakar
Nabia Irfan
Kashif Iqbal Malik
Asif Loya
Erovic M. Boban
Raza Hussain
Arif Jamshed
Publikationsdatum: 25.11.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 8/2021
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-06482-x

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Prognostic outcomes of treatment naïve oral tongue squamous cell carcinoma (OTSCC): a comprehensive analysis of 14 years