Core tip
Background
Methods
Literature search
Study selection criteria
Data extraction and methodological quality assessment
Statistical analysis
Results
Description and quality assessment of studies
The author | Year | Country | Ethnicity | Age (years) | Gender (M/F) | Treatment | Detection method | Outcome | NOS |
---|---|---|---|---|---|---|---|---|---|
Allison, D.C. [16] | 1998 | USA | Caucasians | 63 (32–80) | 40/36 | Operation | Enriched PCR and oligonucleotide hybridization | OS | 6 |
Boeck, S [17] | 2013 | Germany | Caucasians | 64 (32–78) | 105/68 | Chemotherapy | Pyrosequencing | OS | 7 |
Kim, S.T. [18] | 2011 | Korea | Asians | ≥60, n = 84 < 60, n = 52 | 99/37 | Chemotherapy | DS | OS | 7 |
Ogur, T [19] | 2014 | Japan | Asians | 65 (35–84) | 146/96 | Chemotherapy | RT-PCR | OS | 6 |
Schultz, N.A. [6] | 2012 | Denmark | Caucasians | 63 (33–85) | 88/82 | Operation | DS | OS | 7 |
Shin, S.H. [20] | 2013 | Korea | Asians | 60 (22–78) | 139/95 | Operation | PCR-RFLP | OS | 8 |
Sinn, B.V. [7] | 2014 | Germany | Caucasians | ≥65, n = 81; <65, n = 72 | 84/69 | Operation | DS | OS | 7 |
Franko, J [21] | 2008 | USA | Caucasians | 68 ± 12 | 26/24 | Operation and chemotherapy | DS | OS | 6 |
Da Cunha Santos, G [22] | 2010 | Canada | Caucasians | 62 (40–85) | 64/53 | Chemotherapy | PCR and BS | OS | 7 |
Fensterer, H [5] | 2013 | Germany | Caucasians | 62.7 | 36/30 | Operation and chemotherapy | High-resolution melting assay | OS | 6 |
lkeda, N [23] | 2001 | Japan | Asians | 63.7 (47–80) | 37/11 | Operation and chemotherapy | DS | OS | 7 |
Kwon, M.J. [24] | 2011 | Korea | Asians | 63 (45–86) | 37/35 | Operation and chemotherapy | RT-PCR | OS | 8 |
Lee, J [25] | 2007 | Korea | Asians | ≥60, n = 47; <60, n = 19 | 51/15 | Chemotherapy | DS | OS | 5 |
Oh, D.Y. [26] | 2012 | Korea | Asians | 57.3 (39–77) | 24/16 | Chemotherapy | DS | OS | 6 |
Salek, C [27] | 2009 | Czech | Caucasians | 63 ± 10.5 (40–84) | 28/25 | Chemotherapy | GenoScan | OS | 6 |
Kinugasa, H [28] | 2015 | Japan | Asians | 66 (47–85) | 54/21 | NR | Digital PCR | OS | 7 |
Talar-Wojnarowska, R [29] | 2005 | Poland | Caucasians | 47–76 | 10/16 | Operation | PCR-RFLP | OS | 6 |
Author | Year | Country | Ethnicity | Age (years) | Gender (M/F) | K-ras (mutant/wild) | HR (95 % CI) | Outcome | Sites |
---|---|---|---|---|---|---|---|---|---|
Kinugasa, H [28] | 2015 | Japan | Asians | 66 (47–85) | 54/21 | 47/28 | 1.84 (1.1–3.25) | OS | 12, 13, 61 |
Castells, A [12] | 1999 | Spain | Caucasian | NR | NR | 12/32 | 1.51 (1.02–2.23) | OS | 12 |
Chen, H.H. [30] | 2010 | China | Asians | 60 (37–78) | 57/34 | 30/61 | 7.39 (3.7–14.9) | OS | 12 |
Yadama, T [31] | 1998 | Japan | Asians | 63.9 (35–78) | 11/4 | 11/4 | 4.7 (2.8–21.2) | OS | 12 |
Combined | 2.23 (1.69–2.95) | OS |
Quantitative data synthesis
The author | Year | K-ras (mutant/wild) | HR (95 % CI) |
P value | Sites |
---|---|---|---|---|---|
Allison, D.C. [16] | 1998 | 64/12 | 0.70 (0.35–1.43) | 0.330 | NR |
Boeck, S [17] | 2013 | 121/52 | 1.68 (1.17–2.41) | 0.005 | 12, 13 |
Kim, S.T [18] | 2011 | 71/65 | 1.68 (1.18–2.39) | 0.001 | 12, 13 |
Ogur, T [19] | 2014 | 214/28 | 1.76 (1.03–3.01) | 0.040 | 12 |
Schultz, N.A. [6] | 2012 | 136/34 | 1.15 (0.75–1.77) | 0.510 | 12, 13, 61 |
Shin, S.H. [20] | 2013 | 126/108 | 1.63 (1.13–2.34) | 0.001 | 12, 13 |
Sinn, B.V. [7] | 2014 | 105/48 | 1.68 (1.07–2.62) | 0.023 | 12, 13, 61 |
Franko, J [21] | 2008 | 31/19 | 3.28 (1.09–9.90) | 0.035 | 12, 13, 1 |
da Cunha Santos, G [22] | 2010 | 92/25 | 0.68 (0.33–12.42) | 0.300 | 12, 13 |
Fensterer, H [5] | 2013 | 45/21 | 1.28 (0.62–2.64) | 0.180 | 12, 13 |
lkeda, N [23] | 2001 | 33/15 | 1.83 (0.87–3.88) | 0.317 | 12 |
Kwon, M.J. [24] | 2011 | 34/38 | 1.65 (0.90–3.01) | 0.159 | 12, 13, 1 |
Lee, J [25] | 2007 | 33/33 | 1.51 (1.01–2.66) | 0.030 | 12 |
Oh, D.Y. [26] | 2012 | 19/21 | 2.03 (0.43–9.61) | 0.158 | 12, 13 |
Salek, C [27] | 2009 | 36/17 | 0.83 (0.38–1.83) | 0.636 | 12, 13 |
Kinugasa, H [28] | 2015 | 47/28 | 1.59 (0.88–3.07) | 0.124 | 12, 13, 61 |
Talar-Wojnarowska, R [29] | 2005 | 20/6 | 0.87 (0.23–3.29) | 0.580 | 12 |
Subgroup | No. of patients with mutant K-ras | No. of patients without mutant K-ras | HR (95 % CI) | Heterogeneity I
2 (%) | Heterogeneity P value |
---|---|---|---|---|---|
Ethnicity | |||||
Caucasian | 650 | 234 | 1.35 (1.10–1.63) | 28.0 | 0.195 |
Asian | 586 | 327 | 1.65 (1.32–1.72) | 0.0 | 0.136 |
Publication year | |||||
Before 2010 | 309 | 127 | 1.27 (0.96–1.69) | 33.1 | 0.175 |
After 2010 | 927 | 434 | 1.58 (1.36–1.83) | 0.0 | 0.963 |
Tumor resectability | |||||
Resectable | 594 | 301 | 1.44 (1.19–1.74) | 14.3 | 0.315 |
Unresectable | 586 | 241 | 1.57 (1.30–1.91) | 0.0 | 0.686 |
Treatment | |||||
Operation | 451 | 208 | 1.35 (1.09–1.69) | 35.7 | 0.183 |
Chemotherapy | 586 | 241 | 1.57 (1.30–1.91) | 0.0 | 0.686 |
Operation + chemotherapy | 143 | 93 | 1.71 (1.18–2.48) | 0.0 | 0.574 |
Detection methods | |||||
Sequencing | 428 | 235 | 1.57 (1.29–1.90) | 0.0 | 0.644 |
Other methods | 808 | 326 | 1.46 (1.22–1.75) | 2.0 | 0.421 |