Introduction
Methods
Patient selection
Patient follow-up
Automated quantitative system using heart score view software
Statistical analysis
Results
Preliminary comparison of visual and automated scores in prognosis
All cardiac events (n = 13) | No cardiac events (n = 37) |
p value | |
---|---|---|---|
Visual-expert analysis | |||
SSS | 6.6 ± 7.5 | 0.8 ± 1.7* | <0.001 |
SRS | 3.4 ± 6.8 | 0.4 ± 0.7 | 0.010 |
SDS | 3.2 ± 4.2 | 0.5 ± 1.6 | 0.002 |
SBS | 7.3 ± 7.7 | 1.2 ± 3.5 | 0.001 |
Automated analysis (heart score view) | |||
SSS | 5.7 ± 6.7 | 1.5 ± 1.8* | 0.001 |
SRS | 3.2 ± 5.2 | 0.9 ± 2.1 | 0.030 |
SDS | 2.5 ± 2.7 | 0.6 ± 1.9 | 0.006 |
SBS | 6.4 ± 7.5 | 1.9 ± 4.3 | 0.010 |
Visual expert analysis (AUC) | Automated analysis (AUC) |
p value | |
---|---|---|---|
SSS | 0.838 | 0.701 | 0.012 |
SRS | 0.770 | 0.705 | 0.455 |
SDS | 0.716 | 0.689 | 0.722 |
SBS | 0.789 | 0.687 | 0.098 |
Main outcome study
All cardiac events (n = 29) | No cardiac events (n = 122) |
p value | |
---|---|---|---|
Age (years) | 64.7 ± 10.4 | 65.4 ± 10.2 | 0.745 |
Gender (male) | 19/29 (65.5 %) | 64/122(52.5 %) | 0.221 |
Unstable angina pectoris | 5/29 (17.2 %) | 10/122 (8.2 %) | 0.167 |
LVEF (%) | 64.8 ± 10.8 | 69.7 ± 6.8 | 0.003 |
Smoking | 10/29 (34.5 %) | 39/122 (32.0 %) | 0.827 |
Diabetes mellitus | 12/29 (41.4 %) | 9/122 (7.4 %) | <0.001 |
Hypertension | 18/29 (62.1 %) | 58/122 (47.5 %) | 0.215 |
Dyslipidemia | 8/29 (27.6 %) | 37/122 (30.3 %) | 0.826 |
ACE inhibitors | 4/29 (13.9 %) | 16/122 (13.1 %) | 1.000 |
Beta blockers | 4/29 (13.9 %) | 18/122 (14.8 %) | 0.775 |
Calcium channel blockers | 16/29 (55.2 %) | 58/122 (47.5 %) | 0.537 |
SSS | 3.6 ± 5.5 | 1.4 ± 2.2 | 0.001 |
SRS | 1.7 ± 3.8 | 0.7 ± 1.7 | 0.031 |
SDS | 1.9 ± 3.5 | 0.7 ± 1.8 | 0.012 |
SBS | 3.2 ± 5.8 | 1.2 ± 3.2 | 0.030 |
SSS ≥ 4 | 10/29 (34.5 %) | 18/122 (14.8 %) | 0.028 |
SRS ≥ 4 | 3/29 (10.3 %) | 11/122 (9.0 %) | 0.893 |
SDS ≥ 4 | 9/29 (31.0 %) | 12/122 (9.8 %) | 0.008 |
SBS ≥ 4 | 8/29 (27.6 %) | 13/122 (10.7 %) | 0.038 |
Hard cardiac events (n = 7) | No hard cardiac events (n = 144) |
p value | |
---|---|---|---|
Age (years) | 69.7 ± 11.1 | 65.0 ± 10.1 | 0.236 |
Gender (male) | 5/7 (71.4 %) | 78/144 (54.2 %) | 0.459 |
Unstable angina pectoris | 0/7 (0.0 %) | 15/144 (10.4 %) | 1.000 |
LVEF (%) | 59.3 ± 16.3 | 69.2 ± 7.1 | 0.001 |
Smoking | 3/7 (42.9 %) | 46/144 (31.9 %) | 0.682 |
Diabetes mellitus | 4/7 (57.1 %) | 17/144 (11.8 %) | 0.008 |
Hypertension | 3/7 (42.9 %) | 73/144 (50.7 %) | 0.719 |
Dyslipidemia | 0/7 (0.0 %) | 45/144 (31.3 %) | 0.104 |
ACE inhibitors | 1/7 (14.3 %) | 19/144 (13.2 %) | 1.000 |
Beta blockers | 2/7 (28.6 %) | 21/144 (14.6 %) | 0.289 |
Calcium channel blockers | 5/7 (71.4 %) | 69/144 (47.9 %) | 0.270 |
SSS | 9.4 ± 8.3 | 1.5 ± 2.2 | <0.001 |
SRS | 4.9 ± 6.8 | 0.7 ± 1.6 | <0.001 |
SDS | 4.6 ± 5.2 | 0.8 ± 1.9 | <0.001 |
SBS | 7.3 ± 8.7 | 1.3 ± 3.3 | <0.001 |
SSS ≥ 4 | 5/7 (71.4 %) | 23/144 (16.0 %) | 0.001 |
SRS ≥ 4 | 2/7 (28.6 %) | 12/144 (8.3 %) | 0.256 |
SDS ≥ 4 | 4/7 (57.1 %) | 17/144 (11.8 %) | 0.005 |
SBS ≥ 4 | 4/7 (57.1 %) | 17/144 (11.8 %) | 0.005 |
Time dependent analyses using abnormal SPECT scores
Univariable and multivariable analyses
Hazard ratio | 95 % CI |
p value | |
---|---|---|---|
Age (years) | 0.994 | 0.960–1.030 | 0.740 |
Gender (male) | 0.602 | 0.281–1.290 | 0.194 |
Unstable angina pectoris | 2.118 | 0.812–5.530 | 0.127 |
LVEF (%) | 0.922 | 0.882–0.963 | <0.001 |
Smoking | 1.166 | 0.544–2.500 | 0.695 |
Diabetes mellitus | 6.118 | 2.926–12.791 | <0.001 |
Hypertension | 1.791 | 0.848–3.782 | 0.128 |
Dyslipidemia | 0.863 | 0.384–1.940 | 0.722 |
ACE inhibitors | 1.081 | 0.378–3.094 | 0.885 |
Beta blockers | 1.319 | 0.505–3.446 | 0.574 |
Calcium channel blockers | 1.273 | 0.615–2.638 | 0.518 |
SSS | 1.184 | 1.091–1.286 | <0.001 |
SRS | 1.103 | 0.990–1.267 | 0.069 |
SDS | 1.156 | 1.034–1.291 | 0.011 |
SBS | 1.085 | 1.021–1.153 | 0.009 |
SSS ≥ 4 | 2.578 | 1.203–5.527 | 0.015 |
SRS ≥ 4 | 1.106 | 0.336–3.639 | 0.869 |
SDS ≥ 4 | 3.256 | 1.488–7.129 | 0.003 |
SBS ≥ 4 | 2.572 | 1.143–5.787 | 0.023 |
Hazard ratio | 95 % CI |
p value | |
---|---|---|---|
Diabetes mellitus | 5.141 | 2.369–11.156 | <0.001 |
SSS | 1.121 | 1.014–1.239 | 0.026 |
SBS ≥ 4 | 1.139 | 0.439–2.957 | 0.789 |
LVEF | 0.958 | 0.916–1.001 | 0.059 |