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01.04.2015 | Research

Prolactin and Prolactin Receptor Expression in Cervical Intraepithelial Neoplasia and Cancer

verfasst von: Rafael Ascencio-Cedillo, Edgar Ivan López-Pulido, José Francisco Muñoz-Valle, Nicolás Villegas-Sepúlveda, Susana Del Toro-Arreola, Ciro Estrada-Chávez, Adrian Daneri-Navarro, Ramón Franco-Topete, Delia Pérez-Montiel, Alejandro García-Carrancá, Ana Laura Pereira-Suárez

Erschienen in: Pathology & Oncology Research | Ausgabe 2/2015

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Abstract

Prolactin receptor (PRLR) overexpression could play a role in tumorigenesis. The aim of this study was to determine prolactin (PRL) and PRLR expression in biopsies from patients with precursor lesions and uterine cervical cancer. PRLR expression was analyzed in 63 paraffin-embedded biopsies of uterine cervical tissue. In total, eleven low-grade squamous intraepithelial lesions (LSIL), 23 high-grade squamous intraepithelial lesions (HSIL), 21 uterine cervical cancers (UCC) and 8 normal epithelium (NE) were examined using immunoperoxidase staining and Western blot analysis. Additionally, PRL expression was identified in human cervical cancer serum and tissues. The PRLR expression was found to be significantly increased in cervical cancer in comparison with normal tissue and precursor lesions (P < 0.0003). The presence of the long isoform of the PRLR was observed only in cervical cancer tissues. Serum PRL levels were normal in all samples and local prolactin expression was similar in precursor lesions and cervical cancer by Western blot analysis. Our data suggest a possible role for PRLR in the progression of cervical cancer.

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Titel: Prolactin and Prolactin Receptor Expression in Cervical Intraepithelial Neoplasia and Cancer
verfasst von: Rafael Ascencio-Cedillo
Edgar Ivan López-Pulido
José Francisco Muñoz-Valle
Nicolás Villegas-Sepúlveda
Susana Del Toro-Arreola
Ciro Estrada-Chávez
Adrian Daneri-Navarro
Ramón Franco-Topete
Delia Pérez-Montiel
Alejandro García-Carrancá
Ana Laura Pereira-Suárez
Publikationsdatum: 01.04.2015
Verlag: Springer Netherlands
Erschienen in: Pathology & Oncology Research / Ausgabe 2/2015
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-014-9814-6

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25.04.2024 | Nierenkarzinom | Nachrichten

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Prolactin and Prolactin Receptor Expression in Cervical Intraepithelial Neoplasia and Cancer

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