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01.02.2020 | Review

Proteomic profile of saliva collected directly from ducts: a systematic review

verfasst von: Camilla Vieira Esteves, Wladimir Gushiken de Campos, Juliana Amorim dos Santos, Solange Kobayashi Velasco, Eliete Neves Silva Guerra, Walter L. Siqueira, Celso Augusto Lemos

Erschienen in: Clinical Oral Investigations | Ausgabe 2/2020

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Abstract

Objective

To present a systematic review that provides updated information about proteins found in salivary fluid extracted strictly from ducts.

Methods

The systematic review probing strategy was based on electronic databases word search (PubMed, EMBASE, LILACS, Web of Science, and Scopus). Risk of bias was assessed based on Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data.

Results

After 2 rounds of scrutiny, 12 articles were included, totaling 231 individuals (125 were healthy, 41 were elder individuals with radicular caries, 56 had primary Sjögren’s syndrome, and 9 were patients who had received radiotherapy for head and neck cancer). The selected studies had no similarities among proteins found, demonstrating the need of standard reference in experimental methodology to obtain a thorough coverage of proteins.

Conclusion

Further studies are required to better determine the relative amount of proteins described in this study. It is essential to increase the number of samples, to perform similar collection techniques, to include other analyses methods such as mass spectrometry, and to perform the validation of some proteins using immunoassay techniques such as Elisa and Western blot.

Clinical relevance

Proteomic profile of saliva collected from ducts is essential to better understand the disease process, enabling the identification of biomarkers for specific clinical situations.

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Esteves Camilla Vieira, Campos Wladimir Gushiken de, Souza Milena Monteiro de, Lourenço Silvia Vanessa, Siqueira Walter Luiz, Lemos-Júnior Celso Augusto. Diagnostic potential of saliva proteome analysis: a review and guide to clinical practice. Braz. oral res. [Internet]. 2019 [cited 2019 Dec 05] ; 33: e043. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242019000100600&lng=en. Epub May 16, 2019. https://doi.org/10.1590/1807-3107bor-2019.vol33.0043.

Proctor GB (2016) The physiology of salivary secretion. Periodontol 70(1):11–25CrossRef

Dawes C (1972) Circadian rhythms in human salivary flow rate and composition. J Physiol 220(3):529–545CrossRef

Ma, Jonathan, Bruce K. Rubin, and Judith A. Voynow. "Mucins, mucus, and goblet cells." Chest 154.1 (2018): 169-176.

Dawes C (1967) The secretion of magnesium and calcium in human parotid saliva. Caries Res 1(4):333–342CrossRef

Dawes C (1969) The effects of flow rate and duration of stimulation on the concentrations of protein and the main electrolytes in human parotid saliva. Arch Oral Biol 14(3):277–294CrossRef

Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M et al (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 4(1):1CrossRef

Camilla Vieira Esteves, Wladimir Gushiken de Campos, Isabela Porto de Toledo, Walter L Siqueira, Eliete Guerra, Celso Augusto Lemos. Proteomic profile of saliva collected directly from ducts: a systematic review. PROSPERO 2018 CRD42018109152 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018109152

Munn Z, Moola S, Riitano D, Lisy K (2014) The development of a critical appraisal tool for use in systematic reviews addressing questions of prevalence. Int J Health Policy Manag 3(3):123–128CrossRef

10.

Ryu OH, Atkinson JC, Hoehn GT, Illei GG, Hart TC (2006) Identification of parotid salivary biomarkers in Sjögren’s syndrome by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry and two-dimensional difference gel electrophoresis. Rheumatology. 45(9):1077–1086CrossRef

11.

Preza D, Thiede B, Olsen I, Grinde B (2009) The proteome of the human parotid gland secretion in elderly with and without root caries. Acta Odontol Scand 67(3):161–169CrossRef

12.

Laheij AMGA, Rasch CN, Brandt BW, de Soet JJ, Schipper RG, Loof A et al (2015) Proteins and peptides in parotid saliva of irradiated patients compared to that of healthy controls using SELDI-TOF-MS. BMC Res Notes 8(1):639CrossRef

13.

Hall SC, Hassis ME, Williams KE, Albertolle ME, Prakobphol A, Dykstra AB, Laurance M, Ona K, Niles RK, Prasad N, Gormley M, Shiboski C, Criswell LA, Witkowska HE, Fisher SJ (2017) Alterations in the salivary proteome and N-glycome of Sjögren’s syndrome patients. J Proteome Res 16(4):1693–1705CrossRef

14.

Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, Bassilian S, Bedi GS, Boontheung P, Cociorva D, Delahunty CM, Denny T, Dunsmore J, Faull KF, Gilligan J, Gonzalez-Begne M, Halgand F, Hall SC, Han X, Henson B, Hewel J, Hu S, Jeffrey S, Jiang J, Loo JA, Ogorzalek Loo RR, Malamud D, Melvin JE, Miroshnychenko O, Navazesh M, Niles R, Park SK, Prakobphol A, Ramachandran P, Richert M, Robinson S, Sondej M, Souda P, Sullivan MA, Takashima J, Than S, Wang J, Whitelegge JP, Witkowska HE, Wolinsky L, Xie Y, Xu T, Yu W, Ytterberg J, Wong DT, Yates JR 3rd, Fisher SJ (2008) The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res 7(5):1994–2006CrossRef

15.

Walz A, Stühler K, Wattenberg A, Hawranke E, Meyer HEE, Schmalz G, Blüggel M, Ruhl S (2006) Proteome analysis of glandular parotid and submandibular-sublingual saliva in comparison to whole human saliva by two-dimensional gel electrophoresis. Proteomics. 6(5):1631–1639CrossRef

16.

Hardt M, Witkowska HE, Webb S, Thomas LR, Dixon SE, Hall SC et al (2005) Assessing the effects of diurnal variation on the composition of human parotid saliva: quantitative analysis of native peptides using iTRAQ reagents. Anal Chem 77(15):4947–4954CrossRef

17.

Wu S, Brown JN, Tolić N, Meng D, Liu X, Zhang H et al (2014) Quantitative analysis of human salivary gland-derived intact proteome using top-down mass spectrometry. Proteomics. 14(10):1211–1222CrossRef

18.

Hardt M, Thomas LR, Dixon SE et al (2005) Toward defining the human parotid gland salivary proteome and peptidome: identification and characterization using 2D SDS−PAGE, ultrafiltration, HPLC, and mass spectrometry. Biochemistry. 44(8):2885–2899CrossRef

19.

Jasim H, Olausson P, Hedenberg-Magnusson B, Ernberg M, Ghafouri B (2016) The proteomic profile of whole and glandular saliva in healthy pain-free subjects. Sci Rep 6(1):39073CrossRef

20.

Neyraud E, Sayd T, Morzel M, Dransfield E (2006) Proteomic analysis of human whole and parotid salivas following stimulation by different tastes. J Proteome Res 5(9):2474–2480CrossRef

21.

Ramachandran P, Boontheung P, Pang E, Yan W, Wong DT, Loo JA (2008) Comparison of N-linked glycoproteins in human whole saliva, parotid, submandibular, and sublingual glandular secretions identified using hydrazide chemistry and mass spectrometry. Clin Proteomics 4(3–4):80–104CrossRef

22.

Siqueira WL, Dawes C (2011) The salivary proteome: challenges and perspectives. PROTEOMICS-Clinical Appl 5(11–12):575–579CrossRef

23.

Pitt JJ (2009) Principles and applications of liquid chromatography-mass spectrometry in clinical biochemistry. Clin Biochem Rev 30(1):19–34PubMedPubMedCentral

24.

Oppenheim FG, Xu T, McMillian FM, Levitz SM, Diamond RD, Offner GD, Troxler RF (1988) Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans. J Biol Chem 263(16):7472–7477PubMed

25.

Nedelkov D, Kiernan UA, Niederkofler EE, Tubbs KA, Nelson RW (2006) Population proteomics: the concept, attributes, and potential for cancer biomarker research. Mol Cell Proteomics 5(10):1811–1818CrossRef

Titel: Proteomic profile of saliva collected directly from ducts: a systematic review
verfasst von: Camilla Vieira Esteves
Wladimir Gushiken de Campos
Juliana Amorim dos Santos
Solange Kobayashi Velasco
Eliete Neves Silva Guerra
Walter L. Siqueira
Celso Augusto Lemos
Publikationsdatum: 01.02.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 2/2020
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-019-03165-8

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Proteomic profile of saliva collected directly from ducts: a systematic review