Introduction
Ref. | Disease/Activity | Total identified proteins | Samples | Country | Proteomic methods |
---|---|---|---|---|---|
10 | IL-12 regulated CD4+ T cells differentiation | 42 | Blood | Finland | 2-DE |
MS | |||||
13 | T cell proliferation | 17 | Blood | Hong Kong, China | 2-DE |
MALDI-TOF MS | |||||
23 | Mucosal tolerance | 11 | Lymph node | Netherlands | 2D-PAGE |
MALDI-TOF MS | |||||
27 | T-cell vaccination (TCV) | 11 | Activated mouse ovalbumin-specific T cells | P. R. China | 2-DE |
Q-TOF MS | |||||
28 | Vogt-Koyanagi-Harada (VKH) syndrome | 30 | Blood | United States of America | LC-MS/MS |
29 | Rheumatic heart disease (RHD) | 3 | Blood | Brazil | 2-DE |
Cardiac tissue | MALDI-TOF MS | ||||
32 | Tyrosine phosphorylation | 3 | Primary human lymphocyte | United States of America | 2D-PAGE |
37 | Immunosuppression | 10 | E6-1 cell line | Spain | 2D-PAGE |
38 | Colitis | 26 | Lymph node | P. R. China | 2D-PAGE |
MS | |||||
45 | Pseudomonas aeruginosa sepsis | 11 | Blood | P. R. China | 2-DE |
MALDI-TOF MS | |||||
46 | DNA repair capacity (cell-cycle checkpoint-related protein) | 8 | Blood | United States of America | Reverse-phase protein lysate microarray assay |
49 | Asthma | 25 | Blood | South Korea | 2D-PAGE |
MALDI-TOF MS | |||||
50 | Asthma | 13 | Blood | Taiwan, China | 2D-PAGE |
LC/MS |
Autoimmune diseases
Ref. | Activity | Protein | Expression | Functions |
---|---|---|---|---|
10 | T cell differentiation | Macrophage migration inhibitory factor (MIF) | Up-regulated | Cell resque, defense, death, ageing |
Programmed cell death 4 (pdcd4) | Up-regulated | Cell resque, defense, death, ageing | ||
p21-activated kinase 2 (Pak2) | Down-regulated | Signal transduction | ||
Cdc42 | Down-regulated | Signal transduction | ||
Mortalin 2 (Mot-2) | Down-regulated | Protein destination | ||
13 | T cell proliferation | Peroxiredoxin 1 | Up-regulated | A scavenger of reactive organic hydroperoxides |
Proteasomes | Up-regulated | A large multisubunit proteolytic complex that involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway | ||
Triosephosphate isomerase (TIM) | Up-regulted | Enzyme of metabolic pathways like converting glyceraldehyde-3-phosphate to dehydroxyacetone phosphate in the glycolytic pathway | ||
Galectin-1, Chain A | Down-regulated | An anti-inflammatory agent which triggers homeostatic signals to shut off T cell effector functions such as cell proliferation, cell death and cytokines synthesis, cell adhesion and inflammation | ||
23 | T cell supression | Haptoglobin | Up-regulated | Anti-inflammatory activities |
Nonintegrin 67 kDa laminin receptor (LR) | Down-regulated | Lymphocyte migration | ||
MRP8 | Up-regulated | Marker proteins for activated or recruited phagocytes | ||
27 | T cell activation | Calreticulin (CRT) | Identified | Damage-associated molecular pattern molecules, inducing immunogenic apoptosis |
Endoplasmic reticulum protein (ERp57) | ||||
Vimentin |
Identified proteins | Expression | Number of peptides | Function |
---|---|---|---|
Integrin β | Up-regulated | Singe | Protein binding |
Coronin-2A | Up-regulated | Singe | Protein binding |
C19orf2 protein | Up-regulated | Singe | Protein binding |
Isoform 4 of Dystrophin | Up-regulated | Singe | Structural constitute of cytoskeleton, muscle; protein, calcium ion, actin, zinc ion binding |
Synaptonemal complex protein 2 | Up-regulated | Singe | DNA binding |
Hypothetical protein LOC345651 | Up-regulated | Singe | Protein binding |
Isoform 1 of Solute carrier family 22 member 11 | Up-regulated | Singe | Sodium-independent organic anion transporter activity |
UBC; UBB ubiquitin and ribosomal protein S27a precursor | Up-regulated | Singe | Structural constituent of ribosome |
PRA1 family protein 3 | Up-regulated | Singe | Protein binding |
Actin, cytoplasmic 1 | Up-regulated | Singe | Structural constituent of cytoskeleton; protein, ATP, nucleotide binding |
Probable G-protein coupled receptor 179 precursor | Up-regulated | Singe | Metabotropic glutamate, GABA-B-like receptor activity |
Heat shock 70 kDa protein 9, mitochondrial precursor | Up-regulated | Singe | Unfolded protein binding; ATP, nucleotide binding |
ELMO2 protein | Up-regulated | Singe | Binding |
Isoform 1 of Peripherin | Down-regulated | Singe | Structural molecule activity |
ATP synthase subunit α, mitochondrial precursor | Down-regulated | Singe | Protein, ATP, nucleotide, metal ion binding; hydrogen-transporting ATPase/ATP synthase activity; hydrolase, transporter activity |
Calnexin precursor | Down-regulated | Singe | Calcium ion, sugar binding; unfolded protein binding |
Integrin β-2 precursor | Down-regulated | Singe | Protein, protein kinase binding; receptor activity |
Vimentin | Up-regulated | Two or more | Structural constituent of cytoskeleton; protein binding; structural molecule activity; oxygen transporter activity |
Keratin, type I cytoskeletal 10 | Up-regulated | Two or more | Structural constituent of epidermis; structural molecule activity |
ATP synthase subunit β, mitochondrial precursor | Up-regulated | Two or more | Protein, ATP, nucleotide, metal ion binding; hydrogen-transporting ATPase/ATP synthase activity; hydrolase, transporter activity; hydrogen-exporting ATPase activity; nucleotide-triphosphatase activity |
Actin, aortic smooth muscle | Up-regulated | Two or more | Structural constituent of cytoskeleton; protein, ATP, nucleotide binding |
Keratin, type II cytoskeletal 1 | Up-regulated | Two or more | Structural constituent of cytoskeleton; protein, sugar binding; receptor activity |
Uncharacterized protein ALB | Up-regulated | Two or more | Protein, water, toxin, pyridoxal phosphate, drug, fatty acid, oxygen, copper ion, DNA, metal ion binding; carrier, antioxidant activity |
Isoform ASF-1 of Splicing factor, arginine/serine-rich 1 | Down-regulated | Two or more | Protein, nucleotide, RNA binding |