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Erschienen in: Journal of General Internal Medicine 2/2016

01.02.2016 | Original Research

Provider Patient-Sharing Networks and Multiple-Provider Prescribing of Benzodiazepines

verfasst von: Mei-Sing Ong, PhD, Karen L. Olson, PhD, Aurel Cami, PhD, Chunfu Liu, PhD, Fang Tian, PhD, Nandini Selvam, PhD, MPH, Kenneth D. Mandl, MD, MPH

Erschienen in: Journal of General Internal Medicine | Ausgabe 2/2016

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ABSTRACT

Background

Prescription benzodiazepine overdose continues to cause significant morbidity and mortality in the US. Multiple-provider prescribing, due to either fragmented care or “doctor-shopping,” contributes to the problem.

Objective

To elucidate the effect of provider professional relationships on multiple-provider prescribing of benzodiazepines, using social network analytics.

Design

A retrospective analysis of commercial healthcare claims spanning the years 2008 through 2011. Provider patient-sharing networks were modelled using social network analytics. Care team cohesion was measured using care density, defined as the ratio between the total number of patients shared by provider pairs within a patient’s care team and the total number of provider pairs in the care team. Relationships within provider pairs were further quantified using a range of network metrics, including the number and proportion of patients or collaborators shared.

Main Measures

The relationship between patient-sharing network metrics and the likelihood of multiple prescribing of benzodiazepines.

Participants

Patients between the ages of 18 and 64 years who received two or more benzodiazepine prescriptions from multiple providers, with overlapping coverage of more than 14 days.

Results

A total of 5659 patients and 1448 provider pairs were included in our study. Among these, 1028 patients (18.2 %) received multiple prescriptions of benzodiazepines, involving 445 provider pairs (30.7 %). Patients whose providers rarely shared patients had a higher risk of being prescribed overlapping benzodiazepines; the median care density was 8.1 for patients who were prescribed overlapping benzodiazepines and 10.1 for those who were not (p < 0.0001). Provider pairs who shared a greater number of patients and collaborators were less likely to co-prescribe overlapping benzodiazepines.

Conclusions

Our findings demonstrate the importance of care team cohesion in addressing multiple-provider prescribing of controlled substances. Furthermore, we illustrate the potential of the provider network as a surveillance tool to detect and prevent adverse events that could arise due to fragmentation of care.
Literatur
1.
2.
Zurück zum Zitat Jena AB, Goldman D, Schaeffer LD, Weaver L, Karaca-Mandic P. Opioid prescribing by multiple providers in Medicare: retrospective observational study of insurance claims. BMJ. 2014;348:g1393.PubMedCentralCrossRefPubMed Jena AB, Goldman D, Schaeffer LD, Weaver L, Karaca-Mandic P. Opioid prescribing by multiple providers in Medicare: retrospective observational study of insurance claims. BMJ. 2014;348:g1393.PubMedCentralCrossRefPubMed
3.
Zurück zum Zitat Hall AJ, Logan JE, Toblin RL, Kaplan JA, Kraner JC, Bixler D, Crosby AE, Paulozzi LJ. Patterns of abuse among unintentional pharmaceutical overdose fatalities. JAMA. 2008;300:2613–20.CrossRefPubMed Hall AJ, Logan JE, Toblin RL, Kaplan JA, Kraner JC, Bixler D, Crosby AE, Paulozzi LJ. Patterns of abuse among unintentional pharmaceutical overdose fatalities. JAMA. 2008;300:2613–20.CrossRefPubMed
4.
Zurück zum Zitat Wilsey BL, Fishman SM, Gilson AM, Casamalhuapa C, Baxi H, Zhang H, Li CS. Profiling multiple provider prescribing of opioids, benzodiazepines, stimulants, and anorectics. Drug Alcohol Depend. 2010;112:99–106.CrossRefPubMed Wilsey BL, Fishman SM, Gilson AM, Casamalhuapa C, Baxi H, Zhang H, Li CS. Profiling multiple provider prescribing of opioids, benzodiazepines, stimulants, and anorectics. Drug Alcohol Depend. 2010;112:99–106.CrossRefPubMed
5.
Zurück zum Zitat Centers for Disease Control and Prevention (CDC). CDC grand rounds: prescription drug overdoses—a U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012;61:10–3. Centers for Disease Control and Prevention (CDC). CDC grand rounds: prescription drug overdoses—a U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012;61:10–3.
6.
Zurück zum Zitat Jones CM, Mack KA, Paulozzi LJ. Pharmaceutical overdose deaths, United States, 2010. JAMA. 2013;309:657–9.CrossRefPubMed Jones CM, Mack KA, Paulozzi LJ. Pharmaceutical overdose deaths, United States, 2010. JAMA. 2013;309:657–9.CrossRefPubMed
7.
Zurück zum Zitat Substance Abuse and Mental Health Services Administration. Highlights of the 2011 drug abuse warning network (DAWN) findings on drug-related emergency department visits. The DAWN Report; 2013. Substance Abuse and Mental Health Services Administration. Highlights of the 2011 drug abuse warning network (DAWN) findings on drug-related emergency department visits. The DAWN Report; 2013.
8.
Zurück zum Zitat Gugelmann HM, Perrone J. Can prescription drug monitoring programs help limit opioid abuse? JAMA. 2011;306:2258–9.CrossRefPubMed Gugelmann HM, Perrone J. Can prescription drug monitoring programs help limit opioid abuse? JAMA. 2011;306:2258–9.CrossRefPubMed
9.
Zurück zum Zitat Perrone J, Nelson LS. Medication reconciliation for controlled substances—an “ideal” prescription-drug monitoring program. N Engl J Med. 2012;366:2341–3.CrossRefPubMed Perrone J, Nelson LS. Medication reconciliation for controlled substances—an “ideal” prescription-drug monitoring program. N Engl J Med. 2012;366:2341–3.CrossRefPubMed
10.
Zurück zum Zitat Feldman L, Williams KS, Coates J, Knox M. Awareness and utilization of a prescription monitoring program among providers. J Pain Palliat Care Pharmacother. 2011;25:313–7.CrossRefPubMed Feldman L, Williams KS, Coates J, Knox M. Awareness and utilization of a prescription monitoring program among providers. J Pain Palliat Care Pharmacother. 2011;25:313–7.CrossRefPubMed
11.
Zurück zum Zitat Naylor MD, Aiken LH, Kurtzman ET, Olds DM, Hirschman KB. The importance of transitional care in achieving health reform. Health Aff. 2011;30:746–54. Naylor MD, Aiken LH, Kurtzman ET, Olds DM, Hirschman KB. The importance of transitional care in achieving health reform. Health Aff. 2011;30:746–54.
12.
Zurück zum Zitat Berwick DM, Hackbarth AD. Eliminating waste in the US health care. JAMA. 2012;307(14):1513–6.CrossRefPubMed Berwick DM, Hackbarth AD. Eliminating waste in the US health care. JAMA. 2012;307(14):1513–6.CrossRefPubMed
13.
Zurück zum Zitat Medicare Payment Advisory Com- mission. Accountable care organizations. In: Report to the Congress: Improving Incentives in the Medicare Program. Washington (DC): MedPAC; 2009. Medicare Payment Advisory Com- mission. Accountable care organizations. In: Report to the Congress: Improving Incentives in the Medicare Program. Washington (DC): MedPAC; 2009.
14.
Zurück zum Zitat Berwick DM. Launching accountable care organizations—the proposed rules for the medicare shared savings program. N Engl J Med. 2011;364(16), e32.CrossRefPubMed Berwick DM. Launching accountable care organizations—the proposed rules for the medicare shared savings program. N Engl J Med. 2011;364(16), e32.CrossRefPubMed
15.
Zurück zum Zitat Pollack CE, Weissman GE, Lemke KW, Hussey PS, Weiner JP. Patient sharing among providers and costs of care: a network analytic approach to care coordination using claims data. J Gen Intern Med. 2013;28:459–65.PubMedCentralCrossRefPubMed Pollack CE, Weissman GE, Lemke KW, Hussey PS, Weiner JP. Patient sharing among providers and costs of care: a network analytic approach to care coordination using claims data. J Gen Intern Med. 2013;28:459–65.PubMedCentralCrossRefPubMed
16.
Zurück zum Zitat Uddin S, Hossain L, Kelaher M. Effect of provider collaboration network on hospitalization cost and readmission rate. Eur J Pub Health. 2012;22:629–33.CrossRef Uddin S, Hossain L, Kelaher M. Effect of provider collaboration network on hospitalization cost and readmission rate. Eur J Pub Health. 2012;22:629–33.CrossRef
17.
Zurück zum Zitat Barnett ML, Landon BE, O’Malley AJ, Keating NL, Christakis NA. Mapping provider networks with self-reported and administrative data. Health Serv Res. 2011;46:1592–609.PubMedCentralCrossRefPubMed Barnett ML, Landon BE, O’Malley AJ, Keating NL, Christakis NA. Mapping provider networks with self-reported and administrative data. Health Serv Res. 2011;46:1592–609.PubMedCentralCrossRefPubMed
18.
Zurück zum Zitat Landon BE, Keating NL, Barnett ML, Onnela JP, Paul S, O’Malley AJ, Keegan T, Christakis NA. Variation in patient-sharing networks of providers across the United States. JAMA. 2012;308:265–73.PubMedCentralPubMed Landon BE, Keating NL, Barnett ML, Onnela JP, Paul S, O’Malley AJ, Keegan T, Christakis NA. Variation in patient-sharing networks of providers across the United States. JAMA. 2012;308:265–73.PubMedCentralPubMed
20.
Zurück zum Zitat Mandl KD, Olson KL, Mines D, Liu C, Tian F. Provider collaboration: cohesion, constellations, and shared patients. J Gen Intern Med. 2014;29:1499–505.PubMedCentralCrossRefPubMed Mandl KD, Olson KL, Mines D, Liu C, Tian F. Provider collaboration: cohesion, constellations, and shared patients. J Gen Intern Med. 2014;29:1499–505.PubMedCentralCrossRefPubMed
22.
Zurück zum Zitat Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.CrossRefPubMed Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.CrossRefPubMed
23.
Zurück zum Zitat Real R, Vargas JM. The probabilistic basis of Jaccard’s index of similarity. Syst Biol. 1996;45:380–5.CrossRef Real R, Vargas JM. The probabilistic basis of Jaccard’s index of similarity. Syst Biol. 1996;45:380–5.CrossRef
24.
Zurück zum Zitat Mansfield ER, Helms BP. Detecting multicollinearity. Am Stat. 1982;36:158–60. Mansfield ER, Helms BP. Detecting multicollinearity. Am Stat. 1982;36:158–60.
25.
Zurück zum Zitat Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA. 1990;264:2511–8.CrossRefPubMed Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA. 1990;264:2511–8.CrossRefPubMed
26.
Zurück zum Zitat Dunn KM, Saunders KW, Rutter CM, Banta-Green CJ, Merill JO, Sullivan MD, Weisner CM, Silverberg MJ, Campbell CI, Psaty BM, Von Korff M. Opioid prescriptions for chronic pain and overdose. A cohort study. Ann Intern Med. 2010;152:85–92.PubMedCentralCrossRefPubMed Dunn KM, Saunders KW, Rutter CM, Banta-Green CJ, Merill JO, Sullivan MD, Weisner CM, Silverberg MJ, Campbell CI, Psaty BM, Von Korff M. Opioid prescriptions for chronic pain and overdose. A cohort study. Ann Intern Med. 2010;152:85–92.PubMedCentralCrossRefPubMed
27.
Zurück zum Zitat Tamblyn RM, McLeod PJ, Abrahamowicz M, Laprise R. Do too many cooks spoil the broth? Multiple physician involvement in medical management of elderly patients and potentially inappropriate drug combinations. CMAJ. 1996;154:1177–84.PubMedCentralPubMed Tamblyn RM, McLeod PJ, Abrahamowicz M, Laprise R. Do too many cooks spoil the broth? Multiple physician involvement in medical management of elderly patients and potentially inappropriate drug combinations. CMAJ. 1996;154:1177–84.PubMedCentralPubMed
28.
Zurück zum Zitat Han H, Kass PH, Wilsey BL, Li CS. Individual and county-level factors associated with use of multiple prescribers and multiple pharmacies to obtain opioid prescriptions in California. PLoS One. 2012;7, e46246.PubMedCentralCrossRefPubMed Han H, Kass PH, Wilsey BL, Li CS. Individual and county-level factors associated with use of multiple prescribers and multiple pharmacies to obtain opioid prescriptions in California. PLoS One. 2012;7, e46246.PubMedCentralCrossRefPubMed
29.
Zurück zum Zitat Katon WJ, Lin EH, Von Korff M, Ciechanowski P, Ludman EJ, Young B, Peterson D, Rutter CM, McGregor M, McCulloch D. Collaborative care for patients with depression and chronic illnesses. JAMA. 1995;273:1026–1031. N Engl J Med. 2010;363:2611–20.PubMedCentralCrossRefPubMed Katon WJ, Lin EH, Von Korff M, Ciechanowski P, Ludman EJ, Young B, Peterson D, Rutter CM, McGregor M, McCulloch D. Collaborative care for patients with depression and chronic illnesses. JAMA. 1995;273:1026–1031. N Engl J Med. 2010;363:2611–20.PubMedCentralCrossRefPubMed
30.
Zurück zum Zitat Coventry P, Lovell K, Dickens C, Bower P, Chew-Graham C, McElvenny D, Hann M, Cherrington A, Garrett C, Gibbons CJ, Baguley C, Roughley K, Adeyemi I, Reeves D, Waheed W, Gask L. Integrated primary care for patients with mental and physical multimorbidity: cluster randomised controlled trial of collaborative care for patients with depression comorbid with diabetes or cardiovascular disease. BMJ. 2015;350:h638.PubMedCentralCrossRefPubMed Coventry P, Lovell K, Dickens C, Bower P, Chew-Graham C, McElvenny D, Hann M, Cherrington A, Garrett C, Gibbons CJ, Baguley C, Roughley K, Adeyemi I, Reeves D, Waheed W, Gask L. Integrated primary care for patients with mental and physical multimorbidity: cluster randomised controlled trial of collaborative care for patients with depression comorbid with diabetes or cardiovascular disease. BMJ. 2015;350:h638.PubMedCentralCrossRefPubMed
31.
Zurück zum Zitat Rollman BL, Belnap BH, LeMenager MS, Mazumdar S, Houck PR, Counihan PJ, Kapoor WN, Schulberg HC, Reynolds CF 3rd. Telephnoe-delivered collaborative care for treating post-CABG depression: a randomized controlled trial. JAMA. 2009;302:2095–103.PubMedCentralCrossRefPubMed Rollman BL, Belnap BH, LeMenager MS, Mazumdar S, Houck PR, Counihan PJ, Kapoor WN, Schulberg HC, Reynolds CF 3rd. Telephnoe-delivered collaborative care for treating post-CABG depression: a randomized controlled trial. JAMA. 2009;302:2095–103.PubMedCentralCrossRefPubMed
32.
Zurück zum Zitat Unützer J, Katon W, Callahan CM, Williams JW Jr, Hunkeler E, Harpole L, Hoffing M, Della Penna RD, Noël PH, Lin EH, Areán PA, Hegel MT, Tang L, Belin TR, Oishi S, Langston C, IMPACT Investigators. Improving mood-promoting access to collaborative treatment. Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. JAMA. 2002;288:2836–45.CrossRefPubMed Unützer J, Katon W, Callahan CM, Williams JW Jr, Hunkeler E, Harpole L, Hoffing M, Della Penna RD, Noël PH, Lin EH, Areán PA, Hegel MT, Tang L, Belin TR, Oishi S, Langston C, IMPACT Investigators. Improving mood-promoting access to collaborative treatment. Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. JAMA. 2002;288:2836–45.CrossRefPubMed
33.
Zurück zum Zitat Unutzer J, Katon WJ, Fan MY, Schoenbaum MC, Lin EH, Della Penna RD, Powers D. Long-term cost effects of collaborative care for late-life depression. Am J Manage Care. 2008;14:95–100. Unutzer J, Katon WJ, Fan MY, Schoenbaum MC, Lin EH, Della Penna RD, Powers D. Long-term cost effects of collaborative care for late-life depression. Am J Manage Care. 2008;14:95–100.
34.
Zurück zum Zitat Druss BG, Rosenheck RA, Desai MM, Perlin JB. Quality of preventive medical care for patients with mental disorders. Med Care. 2002;40:129–36.CrossRefPubMed Druss BG, Rosenheck RA, Desai MM, Perlin JB. Quality of preventive medical care for patients with mental disorders. Med Care. 2002;40:129–36.CrossRefPubMed
36.
37.
Zurück zum Zitat Bodenheimer T. Coordinating care—a perilous journey through the health care system. N Engl J Med. 2008;358(10):1064–71.CrossRefPubMed Bodenheimer T. Coordinating care—a perilous journey through the health care system. N Engl J Med. 2008;358(10):1064–71.CrossRefPubMed
38.
39.
Zurück zum Zitat Schrag D, Xu F, Hanger M, Elkin E, Bickell NA, Bach PB. Fragmentation of care for frequently hospitalized urban residents. Med Care. 2006;44(6):560-7. Schrag D, Xu F, Hanger M, Elkin E, Bickell NA, Bach PB. Fragmentation of care for frequently hospitalized urban residents. Med Care. 2006;44(6):560-7.
40.
Zurück zum Zitat Kne T, Young R, Spillane L. Frequent ED users: patterns of use over time. Am J Emerg Med. 1998;16(7):648-52. Kne T, Young R, Spillane L. Frequent ED users: patterns of use over time. Am J Emerg Med. 1998;16(7):648-52.
41.
42.
Zurück zum Zitat Paulozzi LJ, Budnitz DS, Xi Y. Increasing deaths from opioid analgesics in the United States. Pharmacoepidemiol Drug Saf. 2006;15:618–27.CrossRefPubMed Paulozzi LJ, Budnitz DS, Xi Y. Increasing deaths from opioid analgesics in the United States. Pharmacoepidemiol Drug Saf. 2006;15:618–27.CrossRefPubMed
43.
Zurück zum Zitat Paulozzi LJ, Kilbourne EM, Desai HA. Prescription drug monitoring programs and death rates from drug overdose. Pain Med. 2011;12:747–54.CrossRefPubMed Paulozzi LJ, Kilbourne EM, Desai HA. Prescription drug monitoring programs and death rates from drug overdose. Pain Med. 2011;12:747–54.CrossRefPubMed
44.
Zurück zum Zitat Cepeda MS, Fife D, Yuan Y, Mastrogiovanni G. Distance travelled and frequency of interstate opioid dispensing in opioid shoppers and nonshoppers. J Pain. 2013;14:1158–61.CrossRefPubMed Cepeda MS, Fife D, Yuan Y, Mastrogiovanni G. Distance travelled and frequency of interstate opioid dispensing in opioid shoppers and nonshoppers. J Pain. 2013;14:1158–61.CrossRefPubMed
45.
Zurück zum Zitat McLellan T, Turner B. Prescription opioids, overdose deaths, and physician responsibility. JAMA. 2008;300:2672–3.CrossRefPubMed McLellan T, Turner B. Prescription opioids, overdose deaths, and physician responsibility. JAMA. 2008;300:2672–3.CrossRefPubMed
Metadaten
Titel
Provider Patient-Sharing Networks and Multiple-Provider Prescribing of Benzodiazepines
verfasst von
Mei-Sing Ong, PhD
Karen L. Olson, PhD
Aurel Cami, PhD
Chunfu Liu, PhD
Fang Tian, PhD
Nandini Selvam, PhD, MPH
Kenneth D. Mandl, MD, MPH
Publikationsdatum
01.02.2016
Verlag
Springer US
Erschienen in
Journal of General Internal Medicine / Ausgabe 2/2016
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-015-3470-8

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