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Clinical Reviews in Allergy & Immunology
Erschienen in: Clinical Reviews in Allergy & Immunology 3/2011

01.12.2011

Pruritus and Atopic Dermatitis

verfasst von: Ulf Darsow, Florian Pfab, Michael Valet, Johannes Huss-Marp, Heidrun Behrendt, Johannes Ring, Sonja Ständer

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 3/2011

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Abstract

Atopic eczema is one of the most pruritic skin diseases. Mediators of atopic eczema itch in the skin are still mostly unknown, but recent studies showed that the histamine 4 receptor plays an important role in itch pathophysiology; tryptase and interleukin-31 are also involved. Differences in itch perception and itch kinetics between healthy volunteers and eczema patients point towards an ongoing central nervous inhibitory activity in patients. Questionnaire studies reported comparatively higher loads in affective items chosen by patients with atopic eczema. In the concept of patient management, the therapy of clinical pruritus has to consider origin and perception of itch, namely the skin and the central nervous system, by combining topical and systemic treatment.
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Metadaten
Titel
Pruritus and Atopic Dermatitis
verfasst von
Ulf Darsow
Florian Pfab
Michael Valet
Johannes Huss-Marp
Heidrun Behrendt
Johannes Ring
Sonja Ständer
Publikationsdatum
01.12.2011
Verlag
Humana Press Inc
Erschienen in
Clinical Reviews in Allergy & Immunology / Ausgabe 3/2011
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-010-8230-2

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