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Erschienen in: Journal of Cancer Survivorship 1/2017

23.08.2016

Psychotropic drug dispensing in people with and without cancer in France

verfasst von: Pierre Verger, Sébastien Cortaredona, Marie Tournier, Dominique Rey, Marc-Karim Bendiane, Patrick Peretti-Watel, Hélène Verdoux

Erschienen in: Journal of Cancer Survivorship | Ausgabe 1/2017

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Abstract

Purpose

To compare annual and monthly prevalence of psychotropic drug (PD) dispensing and the number and duration of psychotropic treatment episodes among people with and without cancer over a 2-year follow-up.

Methods

We studied the following two cohorts of adult patients affiliated with the National Health Insurance Fund (NHIF): cancer patients followed for 2 years after diagnosis and individuals without cancer matched to cancer patients. Using information about anxiolytic, hypnotic, antidepressant, and antipsychotic dispensing in community pharmacies, we applied conditional log-binomial regressions to estimate adjusted relative risks for monthly dispensing of PDs.

Results

Annual prevalence of PD dispensing—all categories included—among cancer patients was significantly higher for almost all the categories we studied than among individuals without cancer. Monthly prevalence of anxiolytic/hypnotic dispensing started to rise several months before diagnosis and peaked immediately after. Among patients with cancer and their matched controls, treatment duration exceeded 1 month for hypnotics in 40 and 35 %, respectively (p < 0.01), and 3 months for anxiolytics in 23 and 23 % (p = 0.8); it was less than 6 months for antidepressants in 76 and 75 % (p = 0.5).

Conclusions

Prevalence of psychotropic treatment was higher among cancer patients than among persons without cancer. Psychotropic treatment duration was not in line with recommendations for significant fractions of cancer patients or their controls.

Implications for cancer survivors

Training of health professionals involved in cancer supportive care should be reinforced and specific guidelines developed to help them address psychological distress of cancer survivors.
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Literatur
1.
3.
Zurück zum Zitat Alfano CM, Rowland JH. Recovery issues in cancer survivorship: a new challenge for supportive care. Cancer J. 2006;12(5):432–43.CrossRefPubMed Alfano CM, Rowland JH. Recovery issues in cancer survivorship: a new challenge for supportive care. Cancer J. 2006;12(5):432–43.CrossRefPubMed
5.
Zurück zum Zitat Bredart A, Kop JL, Griesser AC, Fiszer C, Zaman K, Panes-Ruedin B, et al. Assessment of needs, health-related quality of life, and satisfaction with care in breast cancer patients to better target supportive care. Ann Oncol. 2013;24(8):2151–8. doi:10.1093/annonc/mdt128.CrossRefPubMed Bredart A, Kop JL, Griesser AC, Fiszer C, Zaman K, Panes-Ruedin B, et al. Assessment of needs, health-related quality of life, and satisfaction with care in breast cancer patients to better target supportive care. Ann Oncol. 2013;24(8):2151–8. doi:10.​1093/​annonc/​mdt128.CrossRefPubMed
6.
10.
Zurück zum Zitat Mitchell AJ, Chan M, Bhatti H, Halton M, Grassi L, Johansen C, et al. Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncol. 2011;12(2):160–74. doi:10.1016/S1470-2045(11)70002-X.CrossRefPubMed Mitchell AJ, Chan M, Bhatti H, Halton M, Grassi L, Johansen C, et al. Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncol. 2011;12(2):160–74. doi:10.​1016/​S1470-2045(11)70002-X.CrossRefPubMed
11.
Zurück zum Zitat Mitchell AJ, Ferguson DW, Gill J, Paul J, Symonds P. Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: a systematic review and meta-analysis. Lancet Oncol. 2013;14(8):721–32. doi:10.1016/S1470-2045(13)70244-4.CrossRefPubMed Mitchell AJ, Ferguson DW, Gill J, Paul J, Symonds P. Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: a systematic review and meta-analysis. Lancet Oncol. 2013;14(8):721–32. doi:10.​1016/​S1470-2045(13)70244-4.CrossRefPubMed
12.
Zurück zum Zitat Ng CG, Boks MP, Smeets HM, Zainal NZ, de Wit NJ. Prescription patterns for psychotropic drugs in cancer patients; a large population study in the Netherlands. Psychooncology. 2013;22(4):762–7. doi:10.1002/pon.3056.CrossRefPubMed Ng CG, Boks MP, Smeets HM, Zainal NZ, de Wit NJ. Prescription patterns for psychotropic drugs in cancer patients; a large population study in the Netherlands. Psychooncology. 2013;22(4):762–7. doi:10.​1002/​pon.​3056.CrossRefPubMed
18.
Zurück zum Zitat Derogatis LR, Feldstein M, Morrow G, Schmale A, Schmitt M, Gates C, et al. A survey of psychotropic drug prescriptions in an oncology population. Cancer. 1979;44(5):1919–29.CrossRefPubMed Derogatis LR, Feldstein M, Morrow G, Schmale A, Schmitt M, Gates C, et al. A survey of psychotropic drug prescriptions in an oncology population. Cancer. 1979;44(5):1919–29.CrossRefPubMed
20.
Zurück zum Zitat Jaeger H, Morrow GR, Carpenter PJ, Brescia F. A survey of psychotropic drug utilization by patients with advanced neoplastic disease. Gen Hosp Psychiatry. 1985;7(4):353–60.CrossRefPubMed Jaeger H, Morrow GR, Carpenter PJ, Brescia F. A survey of psychotropic drug utilization by patients with advanced neoplastic disease. Gen Hosp Psychiatry. 1985;7(4):353–60.CrossRefPubMed
21.
Zurück zum Zitat Stiefel FC, Kornblith AB, Holland JC. Changes in the prescription patterns of psychotropic drugs for cancer patients during a 10-year period. Cancer. 1990;65(4):1048–53.CrossRefPubMed Stiefel FC, Kornblith AB, Holland JC. Changes in the prescription patterns of psychotropic drugs for cancer patients during a 10-year period. Cancer. 1990;65(4):1048–53.CrossRefPubMed
22.
Zurück zum Zitat Farriols C, Ferrandez O, Planas J, Ortiz P, Mojal S, Ruiz AI. Changes in the prescription of psychotropic drugs in the palliative care of advanced cancer patients over a seven-year period. J Pain Symptom Manag. 2012;43(5):945–52. doi:10.1016/j.jpainsymman.2011.05.010.CrossRef Farriols C, Ferrandez O, Planas J, Ortiz P, Mojal S, Ruiz AI. Changes in the prescription of psychotropic drugs in the palliative care of advanced cancer patients over a seven-year period. J Pain Symptom Manag. 2012;43(5):945–52. doi:10.​1016/​j.​jpainsymman.​2011.​05.​010.CrossRef
23.
24.
Zurück zum Zitat Sanjida S, Janda M, Kissane D, Shaw J, Pearson S-A, DiSipio T et al. A systematic review and meta-analysis of prescribing practices of antidepressants in cancer patients. Psychooncology. 2016:n/a-n/a. doi:10.1002/pon.4048. Sanjida S, Janda M, Kissane D, Shaw J, Pearson S-A, DiSipio T et al. A systematic review and meta-analysis of prescribing practices of antidepressants in cancer patients. Psychooncology. 2016:n/a-n/a. doi:10.​1002/​pon.​4048.
25.
Zurück zum Zitat Brelin S, Loge JH, Skurtveit S, Johannesen TB, Aass N, Ottesen S, et al. Antidepressants to cancer patients during the last year of life—a population-based study. Psychooncology. 2013;22(3):506–14. doi:10.1002/pon.3059.CrossRefPubMed Brelin S, Loge JH, Skurtveit S, Johannesen TB, Aass N, Ottesen S, et al. Antidepressants to cancer patients during the last year of life—a population-based study. Psychooncology. 2013;22(3):506–14. doi:10.​1002/​pon.​3059.CrossRefPubMed
27.
Zurück zum Zitat Pearson SA, Abrahamowicz M, Srasuebkul P, Buckley NA. Antidepressant therapy in cancer patients: initiation and factors associated with treatment. Pharmacoepidemiol Drug Saf. 2015;24(6):600–9. doi:10.1002/pds.3753.CrossRefPubMed Pearson SA, Abrahamowicz M, Srasuebkul P, Buckley NA. Antidepressant therapy in cancer patients: initiation and factors associated with treatment. Pharmacoepidemiol Drug Saf. 2015;24(6):600–9. doi:10.​1002/​pds.​3753.CrossRefPubMed
28.
Zurück zum Zitat Bouhnik AD, Bendiane MK, Cortaredona S, Sagaon Teyssier L, Rey D, Berenger C, et al. The labour market, psychosocial outcomes and health conditions in cancer survivors: protocol for a nationwide longitudinal survey 2 and 5 years after cancer diagnosis (the VICAN survey). BMJ Open. 2015;5(3):e005971. doi:10.1136/bmjopen-2014-005971.CrossRefPubMedPubMedCentral Bouhnik AD, Bendiane MK, Cortaredona S, Sagaon Teyssier L, Rey D, Berenger C, et al. The labour market, psychosocial outcomes and health conditions in cancer survivors: protocol for a nationwide longitudinal survey 2 and 5 years after cancer diagnosis (the VICAN survey). BMJ Open. 2015;5(3):e005971. doi:10.​1136/​bmjopen-2014-005971.CrossRefPubMedPubMedCentral
30.
31.
32.
Zurück zum Zitat Austin PC. Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Pharm Stat. 2011;10(2):150–61. doi:10.1002/pst.433.CrossRefPubMed Austin PC. Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Pharm Stat. 2011;10(2):150–61. doi:10.​1002/​pst.​433.CrossRefPubMed
35.
Zurück zum Zitat Etchepare F, Sanglier T, Andre M, Verdoux H, Tournier M. Antidepressant treatment patterns in younger and older adults from the general population in a real-life setting. Int J Geriatr Psychiatry. 2014;29(9):928–35. doi:10.1002/gps.4081.CrossRefPubMed Etchepare F, Sanglier T, Andre M, Verdoux H, Tournier M. Antidepressant treatment patterns in younger and older adults from the general population in a real-life setting. Int J Geriatr Psychiatry. 2014;29(9):928–35. doi:10.​1002/​gps.​4081.CrossRefPubMed
36.
37.
Zurück zum Zitat Verdoux H, Cougnard A, Thiebaut A, Tournier M. Impact of duration of antidepressant treatment on the risk of occurrence of a new sequence of antidepressant treatment. Pharmacopsychiatry. 2011;44(3):96–101. doi:10.1055/s-0031-1271686.CrossRefPubMed Verdoux H, Cougnard A, Thiebaut A, Tournier M. Impact of duration of antidepressant treatment on the risk of occurrence of a new sequence of antidepressant treatment. Pharmacopsychiatry. 2011;44(3):96–101. doi:10.​1055/​s-0031-1271686.CrossRefPubMed
42.
Zurück zum Zitat Smith AB, King M, Butow P, Luckett T, Grimison P, Toner GC, et al. The prevalence and correlates of supportive care needs in testicular cancer survivors: a cross-sectional study. Psychooncology. 2013;22(11):2557–64. doi:10.1002/pon.3323.CrossRefPubMed Smith AB, King M, Butow P, Luckett T, Grimison P, Toner GC, et al. The prevalence and correlates of supportive care needs in testicular cancer survivors: a cross-sectional study. Psychooncology. 2013;22(11):2557–64. doi:10.​1002/​pon.​3323.CrossRefPubMed
43.
Zurück zum Zitat Mazzocato C, Stiefel F, Buclin T, Berney A. Psychopharmacology in supportive care of cancer: a review for the clinician: II. Neuroleptics Support Care Cancer. 2000;8(2):89–97.CrossRefPubMed Mazzocato C, Stiefel F, Buclin T, Berney A. Psychopharmacology in supportive care of cancer: a review for the clinician: II. Neuroleptics Support Care Cancer. 2000;8(2):89–97.CrossRefPubMed
44.
Zurück zum Zitat Brocken P, Prins JB, Dekhuijzen PN, van der Heijden HF. The faster the better?—a systematic review on distress in the diagnostic phase of suspected cancer, and the influence of rapid diagnostic pathways. Psychooncology. 2012;21(1):1–10.CrossRefPubMed Brocken P, Prins JB, Dekhuijzen PN, van der Heijden HF. The faster the better?—a systematic review on distress in the diagnostic phase of suspected cancer, and the influence of rapid diagnostic pathways. Psychooncology. 2012;21(1):1–10.CrossRefPubMed
45.
Zurück zum Zitat Howell D, Oliver TK, Keller-Olaman S, Davidson JR, Garland S, Samuels C, et al. Sleep disturbance in adults with cancer: a systematic review of evidence for best practices in assessment and management for clinical practice. Ann Oncol. 2014;25(4):791–800. doi:10.1093/annonc/mdt506.CrossRefPubMed Howell D, Oliver TK, Keller-Olaman S, Davidson JR, Garland S, Samuels C, et al. Sleep disturbance in adults with cancer: a systematic review of evidence for best practices in assessment and management for clinical practice. Ann Oncol. 2014;25(4):791–800. doi:10.​1093/​annonc/​mdt506.CrossRefPubMed
48.
Zurück zum Zitat Jardin M, Bocquier A, Cortaredona S, Nauleau S, Millon C, Savard-Chambard S, et al. Potentially inappropriate prescriptions for the elderly: a study of health insurance reimbursements in southeastern France. Rev Epidemiol Sante Publique. 2012;60(2):121–30. doi:10.1016/j.respe.2011.10.004.CrossRefPubMed Jardin M, Bocquier A, Cortaredona S, Nauleau S, Millon C, Savard-Chambard S, et al. Potentially inappropriate prescriptions for the elderly: a study of health insurance reimbursements in southeastern France. Rev Epidemiol Sante Publique. 2012;60(2):121–30. doi:10.​1016/​j.​respe.​2011.​10.​004.CrossRefPubMed
49.
Zurück zum Zitat Anthierens S, Pasteels I, Habraken H, Steinberg P, Declercq T, Christiaens T. Barriers to nonpharmacologic treatments for stress, anxiety, and insomnia: family physicians’ attitudes toward benzodiazepine prescribing. Can Fam Physician. 2010;56(11):e398–406.PubMedPubMedCentral Anthierens S, Pasteels I, Habraken H, Steinberg P, Declercq T, Christiaens T. Barriers to nonpharmacologic treatments for stress, anxiety, and insomnia: family physicians’ attitudes toward benzodiazepine prescribing. Can Fam Physician. 2010;56(11):e398–406.PubMedPubMedCentral
51.
Zurück zum Zitat Holland JC, Andersen B, Breitbart WS, Compas B, Dudley MM, Fleishman S, et al. Distress management. J Natl Compr Cancer Netw. 2010;8(4):448–85. Holland JC, Andersen B, Breitbart WS, Compas B, Dudley MM, Fleishman S, et al. Distress management. J Natl Compr Cancer Netw. 2010;8(4):448–85.
52.
Zurück zum Zitat National Institute for Health and Clinical Excellence. NICE clinical guideline CG90: the treatment and management of depression in adults. National Institute for Health and Clinical Excellence. 2009. https://www.nice.org.uk/guidance/cg90. Accessed 1 Feb 2015. National Institute for Health and Clinical Excellence. NICE clinical guideline CG90: the treatment and management of depression in adults. National Institute for Health and Clinical Excellence. 2009. https://​www.​nice.​org.​uk/​guidance/​cg90. Accessed 1 Feb 2015.
53.
Zurück zum Zitat National Institute for Health and Clinical Excellence. NICE clinical guideline CG91: depression in adults with chronic physical health problem: recognition and management. National Institute for Health and Clinical Excellence. 2009. https://www.nice.org.uk/guidance/cg91. Accessed 1 Feb 2015. National Institute for Health and Clinical Excellence. NICE clinical guideline CG91: depression in adults with chronic physical health problem: recognition and management. National Institute for Health and Clinical Excellence. 2009. https://​www.​nice.​org.​uk/​guidance/​cg91. Accessed 1 Feb 2015.
57.
Zurück zum Zitat Linden W, MacKenzie R, Rnic K, Marshall C, Vodermaier A. Emotional adjustment over 1 year post-diagnosis in patients with cancer: understanding and predicting adjustment trajectories. Support Care Cancer. 2015;23(5):1391–9. doi:10.1007/s00520-014-2492-9.CrossRefPubMed Linden W, MacKenzie R, Rnic K, Marshall C, Vodermaier A. Emotional adjustment over 1 year post-diagnosis in patients with cancer: understanding and predicting adjustment trajectories. Support Care Cancer. 2015;23(5):1391–9. doi:10.​1007/​s00520-014-2492-9.CrossRefPubMed
58.
Zurück zum Zitat Fiszer C, Dolbeault S, Sultan S, Bredart A. Prevalence, intensity, and predictors of the supportive care needs of women diagnosed with breast cancer: a systematic review. Psychooncology. 2014;23(4):361–74. doi:10.1002/pon.3432.CrossRefPubMed Fiszer C, Dolbeault S, Sultan S, Bredart A. Prevalence, intensity, and predictors of the supportive care needs of women diagnosed with breast cancer: a systematic review. Psychooncology. 2014;23(4):361–74. doi:10.​1002/​pon.​3432.CrossRefPubMed
Metadaten
Titel
Psychotropic drug dispensing in people with and without cancer in France
verfasst von
Pierre Verger
Sébastien Cortaredona
Marie Tournier
Dominique Rey
Marc-Karim Bendiane
Patrick Peretti-Watel
Hélène Verdoux
Publikationsdatum
23.08.2016
Verlag
Springer US
Erschienen in
Journal of Cancer Survivorship / Ausgabe 1/2017
Print ISSN: 1932-2259
Elektronische ISSN: 1932-2267
DOI
https://doi.org/10.1007/s11764-016-0569-9

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