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01.12.2018 | Protocol | Ausgabe 1/2018 Open Access

Systematic Reviews 1/2018

Psychotropic medication non-adherence and associated factors among adult patients with major psychiatric disorders: a protocol for a systematic review

Systematic Reviews > Ausgabe 1/2018
Agumasie Semahegn, Kwasi Torpey, Abubakar Manu, Nega Assefa, Gezahegn Tesfaye, Augustine Ankomah
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s13643-018-0676-y) contains supplementary material, which is available to authorized users.



Evidence from the global burden of diseases show that psychiatric disorders are a growing public health concern. Maintaining adherence to medication is the most essential, but challenging course in the pharmacological treatment modality for major psychiatric disorders. Nevertheless, there is a paucity of abridged evidence on the level of psychotropic medication non-adherence and associated factors. Therefore, we aim to systematically summarize existing primary studies finding to estimate the level and identify associated factors of psychotropic medication non-adherence among adult patients with major psychiatric disorders.


We will search studies using computerized search engines, main electronic databases and other relevant sources. PubMed (Medline), EMBASE, CINAHL, PsycINFO, Web of Science, WHO Global Health Library, and direct Google search will be searched to retrieve studies written in English language before December 2017. Observational studies (cross-sectional, case-control, cohort or longitudinal, survey and surveillance reports) on major psychiatric disorders (schizophrenia, major depressive and bipolar disorders) among adult patients will be eligible. Data will be extracted independently by two authors. Data synthesis and statistical analysis will be carried out. Pooled estimate will be done to quantify the level of psychotropic medication non-adherence using Comprehensive Meta-Analysis software.


Psychiatric disorders remain a public health, social and economic concern worldwide. Management of major psychiatric disorders is highly affected by medication non-adherence. Thus, undertaking an integrated and multifaceted approach is necessary to reduce the burden of medication non-adherence, and enhance the quality of patients’ life. Evidence is required to design appropriate intervention to prevent psychotropic medication non-adherence.

Protocol registration

PROSPERO: 2017: CRD42017067436.
Additional file 1: PRISMA-P checklist. (DOC 85 kb)
Additional file 2: Search strings. (DOCX 33 kb)
Additional file 3: Figure S1. diagramatic presentation of the selection process of artilces for final systeamtic review. (DOCX 37 kb)
Additional file 4: Table S1. Studies description form. (DOCX 16 kb)
Additional file 5: Data extraction Tamplete. (XLSX 10 kb)
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