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European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 4/2003

01.04.2003 | Original Article

Quantitative cerebral H2 15O perfusion PET without arterial blood sampling, a method based on washout rate

verfasst von: Valerie Treyer, Mathieu Jobin, Cyrill Burger, Vincenzo Teneggi, Alfred Buck

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 4/2003

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Abstract

The quantitative determination of regional cerebral blood flow (rCBF) is important in certain clinical and research applications. The disadvantage of most quantitative methods using H2 15O positron emission tomography (PET) is the need for arterial blood sampling. In this study a new non-invasive method for rCBF quantification was evaluated. The method is based on the washout rate of H2 15O following intravenous injection. All results were obtained with Alpert's method, which yields maps of the washin parameter K 1 (rCBFK1) and the washout parameter k 2 (rCBFk2). Maps of rCBFK1 were computed with measured arterial input curves. Maps of rCBFk2* were calculated with a standard input curve which was the mean of eight individual input curves. The mean of grey matter rCBFk2* (CBFk2*) was then compared with the mean of rCBFK1 (CBFK1) in ten healthy volunteer smokers who underwent two PET sessions on day 1 and day 3. Each session consisted of three serial H2 15O scans. Reproducibility was analysed using the rCBF difference scan 3−scan 2 in each session. The perfusion reserve (PR = rCBFacetazolamide−rCBFbaseline) following acetazolamide challenge was calculated with rCBFk2* (PRk2*) and rCBFK1 (PRK1) in ten patients with cerebrovascular disease. The difference CBFk2*−CBFK1 was 5.90±8.12 ml/min/100 ml (mean±SD, n=55). The SD of the scan 3−scan 1 difference was 6.1% for rCBFk2* and rCBFK1, demonstrating a high reproducibility. Perfusion reserve values determined with rCBFK1 and rCBFk2* were in high agreement (difference PRk2*−PRK1=−6.5±10.4%, PR expressed in percentage increase from baseline). In conclusion, a new non-invasive method for the quantitative determination of rCBF is presented. The method is in good agreement with Alpert's original method and the reproducibility is high. It does not require arterial blood sampling, yields quantitative voxel-by-voxel maps of rCBF, and is computationally efficient and easy to implement.
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Metadaten
Titel
Quantitative cerebral H2 15O perfusion PET without arterial blood sampling, a method based on washout rate
verfasst von
Valerie Treyer
Mathieu Jobin
Cyrill Burger
Vincenzo Teneggi
Alfred Buck
Publikationsdatum
01.04.2003
Verlag
Springer-Verlag
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 4/2003
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-002-1105-x

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