01.03.2015 | Letter to the Editor
Quantitative Methods for Prediction of the Effect of Cytochrome P450 Gene Polymorphisms on Substrate Drug Exposure
Erschienen in: Clinical Pharmacokinetics | Ausgabe 3/2015
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We read with interest the article by Chang and colleagues who studied the influence of cytochrome P450 2C19 (CYP2C19) genetic polymorphism on citalopram and escitalopram exposure by using meta-analysis [1]. The authors state that this is the first study which provides precise estimates of the influence of CYP2C19 genotypes on (es)citalopram drug exposure, especially for heterozygous genotypes with the CYP2C19*17 gain-of-function allele. …Anzeige