Introduction
Eighteen to 37% of glioblastoma patients present in a poor pre- or postoperative performance status at the time of diagnosis (Chang et al.
2003; Lutterbach et al.
2003; Bauchet et al.
2010; Gulati et al.
2011; Scott et al.
2012; Stark et al.
2012; Badaoui et al.
2014; McNamara et al.
2014; Zouaoui et al.
2014; Gramatzki et al.
2017). Performance status, age, mental status and extent of surgical resection have been confirmed as important prognostic factors in these patients, and low performance status at diagnosis indicates a particularly poor prognosis (Curran et al.
1993; Li et al.
2011; Scott et al.
2012).
The standard treatment of glioblastoma consists of surgery followed by radiotherapy in 30 fractions and concurrent and maintenance systemic therapy with temozolomide (TMZ) (Stupp et al.
2005; Wen et al.
2020; Weller et al.
2021). However, patients in poor performance status or elderly patients (> 70 years), are usually treated with adapted treatment regimens such as short course radiotherapy with or without chemotherapy, or alkylating chemotherapy only in O
6-methylguanine-DNA methyltransferase (
MGMT) promotor methylated patients (Roa et al.
2004; Malmstrom et al.
2012; Wick et al.
2012; Perry et al.
2017). Likewise, almost all clinical trials with experimental drugs preclude the enrolment of patients with poor performance status.
For elderly patients in good performance status, a survival benefit from radiotherapy after surgical resection of different extent has been confirmed (Keime-Guibert et al.
2007). However, data regarding the treatment of patients in poor performance status is scarce, especially considering that those patients are usually excluded from clinical trials, which minimizes the availability of data on potential benefit or harm for this selected patient group. A trial of 70 patients with a median Karnofsky performance status (KPS) of 60% compared the benefit of temozolomide therapy only to a historical control of patients treated with best supportive care. Temozolomide alone was characterized by acceptable tolerability especially in patients with a methylated MGMT-promotor and was associated with an improvement of the functional status. However, radiotherapy was not part of this study (Gallego Perez-Larraya et al.
2011).
To further evaluate a potential benefit of radiotherapy in patients with low performance status at diagnosis, we retrospectively analyzed the data of 43 patients with poor performance status receiving additive radiotherapy, either alone or in combination with chemotherapy, and of a control group of 50 patients receiving a diagnostic biopsy, partial or gross total resection without further tumor-targeted therapy.
Material and methods
Data source
We conducted a retrospective single center cohort study of glioblastoma patients > 18 years at diagnosis, treated at the University Hospital Zurich between April 2005 and June 2019, with poor postoperative performance status (ECOG PS 2–4) after biopsy or neurosurgical resection in the first-line setting. Electronic patient files and pathology reports were the main source of data acquisition. The study was conducted in accordance with the Declaration of Helsinki and applicable regulatory requirements and has been approved by the local ethics committee (KEK-ZH-Nr. 2009-0135/1; KEK-ZH-Nr. 2015-0437).
Disease and treatment characteristics
All tumors were classified according to the World Health Organization (WHO) 2007 criteria in the local pathology department, for patients diagnosed before 2016, and according to the WHO 2016 criteria for patients diagnosed after that time. In a second step all tumors classified by the 2007 criteria were re-classified by IDH mutation status in accordance with the WHO 2016 classification when sufficient tissue was available. IDH1/2 status was obtained by immunohistochemistry or sequencing analysis; MGMT promotor methylation status was determined by methylation-specific PCR. Extent of resection was assessed based on early postoperative imaging reports in all patients. For treatment planning, planning CT scans as well as MRI were used. The gross tumor volume (GTV) was contoured as the primary tumor (if biopsy only) or the resection cavity including contrast-enhanced regions. A safety margin of 1.5 cm was added to derive the clinical target volume (CTV). An additional planning target volume (PTV) margin was added to compensate for setup errors. For grading of toxicity, CTCAE V. 5.0 was used.
Statistical analysis
Overall survival was calculated according to the Kaplan–Meier method. Overall survival from the time of surgery (biopsy or resection) to death or from end of radiotherapy to death were calculated. Additional factors were analyzed using the log-rank test. Univariate and multivariate analyses were done using Cox regression. The multivariate model was applied to all patients who had complete information on all tested co-variables. For statistical analysis of patient characteristics and performance status, the Chi-squared test and the Fisher’s exact test were used. For statistical analysis, SPSS Version 25 was used (SPSS IBM Corp., Armonk, NY, USA).
Discussion
This retrospective single-institution analysis addressed the value of radiotherapy compared to best supportive care in glioblastoma patients with poor postoperative performance status in the first-line setting.
Performance status is a well-documented prognostic factor for overall survival in glioblastoma patients, the most important factors being age (< 50 vs. ≥ 50 years) (Curran et al.
1993; Li et al.
2011) or type of surgery (Gross total resection/partial resection vs. biopsy) (Scott et al.
2012). However, with regard to the optimal treatment recommendation of patients in poor performance status, reliable data is sparse (Curran et al.
1993; Lutterbach et al.
2003; Li et al.
2011; Scott et al.
2012; Stark et al.
2012; McNamara et al.
2014; Gately et al.
2016; Glynn, Rangaswamy et al.
2019). The median overall survival of patients with poor performance status is short with 2.3–6.6 months from the time of diagnosis, although the definition of poor performance status is inconsistent. In a cohort published by Scott et al., patients with biopsy only and a KPS < 70% had a median OS of 2.3 months. Patients with more extensive surgeries had a better overall survival, independent of performance status (Scott et al.
2012). Marina et al. analyzed data of patients with a KPS < 50% in a cohort with about half of patients biopsied only, and 64% of patients receiving radiotherapy, and reported a median overall survival from the date of the most excessive surgery of 2.3 month, too (Marina et al.
2011).
In our cohort, the median survival from diagnosis was 27 weeks in all patients treated with radiotherapy, and 13 weeks in the biopsy only followed by radiotherapy group. Survival from the end of radiotherapy was median 13 weeks for all patients treated with radiotherapy and 8 weeks for biopsy followed by radiotherapy. This indicates patients treated with biopsy only are at increased risk of early death irrespective of post-biopsy radiotherapy. Admittedly, our radiotherapy group comprised more patients with gross total resection compared to the best supportive care group. Yet, without post-surgery radiotherapy, survival does not increase with gross total resection compared to biopsy only, underlining the role of radiotherapy (Fig.
2A, B), and the median overall survival from diagnosis was significantly better in the radiotherapy group than in the control group (10 weeks) irrespective of performance status or extent of surgical resection. Landmark analyses at 4 and 8 weeks confirmed the survival benefit in the radiotherapy group (Fig.
3).
In patients with poor performance status, survival is only one aspect to consider. Another important question is whether impaired patients may benefit from radiation therapy in terms of performance status improvement. Very few data are available on this topic, and especially prospective data is rare. Retrospective data and data from a phase II trial suggest that KPS might improve by 10–30% in up to 70% patients with radiotherapy, but overall patient numbers are small (Gallego Perez-Larraya et al.
2011; Marina et al.
2011; Reyngold et al.
2012). In this analysis, 30% of patients had an improvement in performance status of 1–2 after radiotherapy, consistent with previous data. One fifth of our patient population regained an ECOG ≥ 1, allowing for self-care, and therefore representing a factor of autonomy for the patient.
Another factor to consider is treatment-induced toxicity. Radiation-induced toxicity for glioblastoma patients is usually low, e.g., 8% ≥ G3 toxicity in the radiation arm (Malmstrom et al.
2012; Wick et al.
2012) in a group of elderly, therefore more vulnerable, patients. This is confirmed in our study with no case of grade 3 or higher radiation-induced toxicity. Treatment with TMZ, either as monotherapy or with radiation, causes mostly hematologic ≤ G3 toxicity in up to 25% of patients (Stupp et al.
2005; Gallego Perez-Larraya et al.
2011; Malmstrom et al.
2012).
Short course radiation treatment is the standard of care in elderly and poor-performance status patients with unmethylated MGMT-promotor (Guedes de Castro et al.
2017; Weller et al.
2017), which limits the total treatment time to 3 weeks and 15 radiotherapy sessions. All patients in our study were treated with hypo-fractionated radiotherapy; however, it was interesting that the benefit of radiotherapy was restricted to patients treated with 40.05 Gy in 15 fractions, whereas no benefit was observed for lower-dose radiotherapy. Best-supportive care or shorter fractionated radiotherapy should, therefore, be considered for patients not eligible for a full-course radiotherapy of 15 fractions over three weeks.
Despite absolute overall survival is short in glioblastoma patients with poor performance status, as reported above, radiotherapy was well-tolerated as delivered over maximum three weeks and appears favorable considering that median overall survival is prolonged by a factor of almost three. However, careful and balanced patient information about the absolute and relative benefits of surgery and postoperative radiotherapy and chemotherapy is mandatory.
Limitations of this study include the retrospective nature of this small population with heterogeneous treatment, including combination of chemotherapeutics with radiotherapy as part of the first-line treatment. However, there was no significant imbalance with regard to MGMT promotor methylation as predictive marker in the radiotherapy plus systemic treatment group, which could have indicated a better response to additional chemotherapy. Also, lack of patient-reported outcomes in this retrospective analysis precludes a statement on subjective benefits and quality of life in this specific patient population, therefore omitting a relevant patient-centered outcome surrogate. Still, the inclusion of relevant numbers of patients biopsied only, in both radiotherapy and control group (25 vs. 26 patients, respectively), provides more information on this patient group with poor predictors of outcome that may benefit with regard to the performance status improvement.
In conclusion, this retrospective single-institution analysis observed a significant and clinically relevant overall survival benefit of radiotherapy in glioblastoma patients with poor performance status. However, considering the short absolute overall survival, especially in patients not eligible for neurosurgical resection, the potential benefit of prolonged survival must be carefully weighted against the large portion of extended lifespan being spent under treatment. Better prognostic and predictive factors for patient selection are urgently needed. Most importantly, quality-of-life and patient-reported outcome need to be considered in addition to sole overall survival and should be incorporated not only into clinical studies, but also as routine practice, including patients in reduced performance status who are usually excluded from study populations (Coomans et al.
2019; Hertler et al.
2020).
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