Background
Methods
Specimens
Cytogenetic analysis
Reverse transcription PCR
Quantitative real-time PCR
Statistical analysis
Consent
Results
Cytogenetic findings
Sex | Age (years) | Location | Total | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Karyotype | M | F | 20-40 | 40-60 | >60 | U | L | T | H | = 66 |
Normal
| 6 | 4 | 2 | 6 | 2 | 1 | 1 | 3 | 5 | 10 (15%) |
Abnormal
| 36 | 20 | 5 | 23 | 28 | 13 | 17 | 17 | 9 | 56 (85%) |
Ring/Giant chromosome
|
1
|
3
|
0
|
1
|
3
|
1
|
2
|
1
|
0
|
4 (7%)
|
12q13-15 rearrangement
|
13
|
8
|
0
|
8
|
13
|
6
|
7
|
7
|
1
|
21 (38%)
|
13q rearrangement
|
5
|
1
|
0
|
2
|
4
|
0
|
1
|
1
|
4
|
6 (11%)
|
6p21-23 rearrangement
|
2
|
1
|
1
|
0
|
2
|
1
|
0
|
1
|
1
|
3 (5%)
|
Other
|
17
|
8
|
4
|
13
|
8
|
5
|
8
|
7
|
5
|
25 (45%)
|
Sex | Age (years) | Location | Total | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Karyotype | M | F | 20-40 | 40-60 | >60 | U | L | T | H | = 38 |
Normal
| 1 | 1 | 0 | 1 | 1 | 0 | 2 | 0 | 0 | 2 (5%) |
Abnormal
| 21 | 15 | 2 | 16 | 18 | 6 | 20 | 8 | 2 | 36 (95%) |
Ring/Giant chromosome
|
7
|
8
|
1
|
5
|
9
|
1
|
9
|
5
|
0
|
15 (42%)
|
12q13-15 rearrangement
|
4
|
1
|
0
|
2
|
3
|
1
|
3
|
0
|
1
|
5 (14%)
|
13q rearrangement
|
4
|
1
|
0
|
3
|
2
|
3
|
1
|
1
|
0
|
5 (14%)
|
6p21-23 rearrangement
|
1
|
2
|
0
|
2
|
1
|
1
|
1
|
0
|
1
|
3 (8%)
|
Other
|
5
|
5
|
1
|
3
|
6
|
1
|
7
|
2
|
0
|
10 (28%)
|
HMGA2fusion genes
Lipoma | ALT/WDL | |
---|---|---|
HMGA2-LPP(+) | 9 (9%) | 1 (3%) |
HMGA2-RDC1(+) | 3 (3%) | 0 (0%) |
HMGA2-NFIB(+) | 0 (0%) | 0 (0%) |
Fusion gene(-) | 85 (88%) | 31 (97%) |